Leptomeningeal plasmacytosis: Case report and considerations on treatment
We describe a 68-year-old patient with a plasma cell leukaemia in haematological remission presenting with massive intracranial leptomeningeal plasmocytic infiltration (LPI) and hydrocephalus. He was treated with skull irradiation and a combination of intraventricular and lumbar intrathecal therapy...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 1989, Vol.91 (4), p.355-359 |
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| container_title | Clinical neurology and neurosurgery |
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| creator | Schiphof, Paul R. Vanneste, Jan A.L. Ploem, Jan E. |
| description | We describe a 68-year-old patient with a plasma cell leukaemia in haematological remission presenting with massive intracranial leptomeningeal plasmocytic infiltration (LPI) and hydrocephalus. He was treated with skull irradiation and a combination of intraventricular and lumbar intrathecal therapy with methotrexate. Neurologic improvement and clearance of plasma cells from the cerebrospinal fluid was reached after 2 weeks of treatment but prolonged follow-up was interrupted by a lethal gastro-intestinal haemorrhage, 6 weeks after starting the therapy. From previously reported cases it is known that LPI almost always occurs in either high-grade plasmocytomas or plasma cell leukaemia. These data suggest that therapy of LPI should be the same as in other leukaemias with leptomeningeal infiltration. |
| doi_str_mv | 10.1016/0303-8467(89)90015-2 |
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He was treated with skull irradiation and a combination of intraventricular and lumbar intrathecal therapy with methotrexate. Neurologic improvement and clearance of plasma cells from the cerebrospinal fluid was reached after 2 weeks of treatment but prolonged follow-up was interrupted by a lethal gastro-intestinal haemorrhage, 6 weeks after starting the therapy. From previously reported cases it is known that LPI almost always occurs in either high-grade plasmocytomas or plasma cell leukaemia. These data suggest that therapy of LPI should be the same as in other leukaemias with leptomeningeal infiltration.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/0303-8467(89)90015-2</identifier><identifier>PMID: 2555099</identifier><identifier>CODEN: CNNSBV</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Aged ; Biological and medical sciences ; Brain Neoplasms - radiotherapy ; Brain Neoplasms - secondary ; Hematologic and hematopoietic diseases ; Humans ; Hydrocephalus - etiology ; leptomeningeal infiltration ; leukaemia ; Leukemia, Plasma Cell ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; multiple-myeloma ; paraproteinemias ; Plasmacytoma - radiotherapy ; Plasmacytoma - secondary</subject><ispartof>Clinical neurology and neurosurgery, 1989, Vol.91 (4), p.355-359</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0303846789900152$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6620631$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2555099$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schiphof, Paul R.</creatorcontrib><creatorcontrib>Vanneste, Jan A.L.</creatorcontrib><creatorcontrib>Ploem, Jan E.</creatorcontrib><title>Leptomeningeal plasmacytosis: Case report and considerations on treatment</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>We describe a 68-year-old patient with a plasma cell leukaemia in haematological remission presenting with massive intracranial leptomeningeal plasmocytic infiltration (LPI) and hydrocephalus. He was treated with skull irradiation and a combination of intraventricular and lumbar intrathecal therapy with methotrexate. Neurologic improvement and clearance of plasma cells from the cerebrospinal fluid was reached after 2 weeks of treatment but prolonged follow-up was interrupted by a lethal gastro-intestinal haemorrhage, 6 weeks after starting the therapy. From previously reported cases it is known that LPI almost always occurs in either high-grade plasmocytomas or plasma cell leukaemia. These data suggest that therapy of LPI should be the same as in other leukaemias with leptomeningeal infiltration.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - radiotherapy</subject><subject>Brain Neoplasms - secondary</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Hydrocephalus - etiology</subject><subject>leptomeningeal infiltration</subject><subject>leukaemia</subject><subject>Leukemia, Plasma Cell</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>multiple-myeloma</subject><subject>paraproteinemias</subject><subject>Plasmacytoma - radiotherapy</subject><subject>Plasmacytoma - secondary</subject><issn>0303-8467</issn><issn>1872-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kc1LxDAQxYMo67r6Hyj0IKKH6qRp0sSDIIsfCwte9BzSdCqRfplkhf3v7brF0wy83wy89wg5p3BLgYo7YMBSmYviWqobBUB5mh2QOZVFlgol5CGZ_yPH5CSELwBgTMgZmWWcc1BqTlZrHGLfYue6TzRNMjQmtMZuYx9cuE-WJmDiceh9TExXJbbvgqvQm-jGLem7JHo0cbyPp-SoNk3As2kuyMfz0_vyNV2_vayWj-sUMwUxtSizghsOWNqSFbaWwjKwWV4WhSo5lJArpvIaVEVrLvJa0TKnTICQqrJKsAW52v8dfP-9wRB164LFpjEd9pugC8UYLwQbwYsJ3JQtVnrwrjV-qyfvo3456SZY09TedNaFf0yIDASjI_awx3A09ePQ62AddhYr59FGXfVOU9C7SvQub73LW0ul_yrRGfsFcNh8lA</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Schiphof, Paul R.</creator><creator>Vanneste, Jan A.L.</creator><creator>Ploem, Jan E.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Leptomeningeal plasmacytosis: Case report and considerations on treatment</title><author>Schiphof, Paul R. ; Vanneste, Jan A.L. ; Ploem, Jan E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e290t-ce8275a50ebcb37cf86c30c24b779b50b049394f09d1f564f91b41360689dc963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - radiotherapy</topic><topic>Brain Neoplasms - secondary</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Hydrocephalus - etiology</topic><topic>leptomeningeal infiltration</topic><topic>leukaemia</topic><topic>Leukemia, Plasma Cell</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>multiple-myeloma</topic><topic>paraproteinemias</topic><topic>Plasmacytoma - radiotherapy</topic><topic>Plasmacytoma - secondary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schiphof, Paul R.</creatorcontrib><creatorcontrib>Vanneste, Jan A.L.</creatorcontrib><creatorcontrib>Ploem, Jan E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurology and neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schiphof, Paul R.</au><au>Vanneste, Jan A.L.</au><au>Ploem, Jan E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leptomeningeal plasmacytosis: Case report and considerations on treatment</atitle><jtitle>Clinical neurology and neurosurgery</jtitle><addtitle>Clin Neurol Neurosurg</addtitle><date>1989</date><risdate>1989</risdate><volume>91</volume><issue>4</issue><spage>355</spage><epage>359</epage><pages>355-359</pages><issn>0303-8467</issn><eissn>1872-6968</eissn><coden>CNNSBV</coden><abstract>We describe a 68-year-old patient with a plasma cell leukaemia in haematological remission presenting with massive intracranial leptomeningeal plasmocytic infiltration (LPI) and hydrocephalus. He was treated with skull irradiation and a combination of intraventricular and lumbar intrathecal therapy with methotrexate. Neurologic improvement and clearance of plasma cells from the cerebrospinal fluid was reached after 2 weeks of treatment but prolonged follow-up was interrupted by a lethal gastro-intestinal haemorrhage, 6 weeks after starting the therapy. From previously reported cases it is known that LPI almost always occurs in either high-grade plasmocytomas or plasma cell leukaemia. These data suggest that therapy of LPI should be the same as in other leukaemias with leptomeningeal infiltration.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2555099</pmid><doi>10.1016/0303-8467(89)90015-2</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0303-8467 |
| ispartof | Clinical neurology and neurosurgery, 1989, Vol.91 (4), p.355-359 |
| issn | 0303-8467 1872-6968 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Biological and medical sciences Brain Neoplasms - radiotherapy Brain Neoplasms - secondary Hematologic and hematopoietic diseases Humans Hydrocephalus - etiology leptomeningeal infiltration leukaemia Leukemia, Plasma Cell Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences multiple-myeloma paraproteinemias Plasmacytoma - radiotherapy Plasmacytoma - secondary |
| title | Leptomeningeal plasmacytosis: Case report and considerations on treatment |
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