Studies on Anti-inflammatory Agents. V. Synthesis and Pharmacological Properties of 3-(Difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyrazole and Related Compounds

A series of novel 1, 5-diphenylpyrazole derivatives bearing hydrophilic substituents was prepared. The anti-inflammatory and analgesic activities of these compounds were evaluated by using the adjuvant arthritis and Randall-Selitto assays in rats, and the structure-activity relationships were studie...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1997/09/15, Vol.45(9), pp.1475-1481
Hauptverfasser:	TSUJI, Kiyoshi, KONISHI, Nobukiyo, SPEARS, Glen W., OGINO, Takashi, NAKAMURA, Katsuya, TOJO, Takashi, OCHI, Takehiro, SHIMOJO, Fumio, SENOH, Hachiro, MATSUO, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	1, 5-diphenylpyrazole analgesic activity Analgesics Animals anti-inflammatory agent Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Chromatography, High Pressure Liquid Crystallography, X-Ray Magnetic Resonance Spectroscopy Male Mass Spectrometry Medical sciences Molecular Structure morphine Neuropharmacology Pharmacology. Drug treatments Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Structure-Activity Relationship Sulfoxides - chemical synthesis Sulfoxides - chemistry Sulfoxides - pharmacology
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