Ki-67 antigen in ameloblastomas: correlation with clinical and histological parameters in 54 cases from Kenya
The aim of this study was to assess the cell proliferation in ameloblastomas and to correlate this with clinical features and histology. Immunohistochemistry with Ki-67 monoclonal antibody was performed on fresh tissue from 54 ameloblastomas. A labelling index (LI) was calculated by expressing the p...
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| Veröffentlicht in: | International journal of oral and maxillofacial surgery 1997-10, Vol.26 (5), p.376-379 |
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| creator | Ong'uti, Meshach N. Cruchley, Alan T. Howells, Gareth L. Williams, David M. |
| description | The aim of this study was to assess the cell proliferation in ameloblastomas and to correlate this with clinical features and histology. Immunohistochemistry with Ki-67 monoclonal antibody was performed on fresh tissue from 54 ameloblastomas. A labelling index (LI) was calculated by expressing the percentage of Ki-67 positive cells. There was no significant correlation between LI and clinical features: age, sex or tumour size. Follicular ameloblastomas had significantly higher LI (5.0±0.5; mean±
sem) than plexiform tumours (3.2±0.6;
P |
| doi_str_mv | 10.1016/S0901-5027(97)80801-6 |
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sem) than plexiform tumours (3.2±0.6;
P<0.05). Plexiform ameloblastomas from the anterior mandible had a significantly lower LI (1.8±0.5) than those from the posterior (3.9±0.8;
P<0.05). LI was higher in squamous arcades (6.4±3.1%) than in epithelial cords and cysts (1.4±1.3%
P<0.001). These results suggest that LI correlates most closely with the histological pattern of the epithelium of ameloblastoma, both within and between different tumours.</description><identifier>ISSN: 0901-5027</identifier><identifier>EISSN: 1399-0020</identifier><identifier>DOI: 10.1016/S0901-5027(97)80801-6</identifier><identifier>PMID: 9327291</identifier><identifier>CODEN: IJOSE9</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Age Factors ; Aged ; ameloblastoma ; Ameloblastoma - classification ; Ameloblastoma - pathology ; Antibodies, Monoclonal ; Biological and medical sciences ; Cell Division ; Cell Nucleus - ultrastructure ; Child ; Cysts - pathology ; Dentistry ; Ent. Stomatology ; Epithelium - pathology ; Female ; Humans ; Immunoenzyme Techniques ; immunohistochemistry ; Investigative techniques, diagnostic techniques (general aspects) ; Kenya ; Ki-67 ; Ki-67 Antigen - analysis ; Male ; Mandibular Neoplasms - pathology ; Maxillary Neoplasms - pathology ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Sex Factors</subject><ispartof>International journal of oral and maxillofacial surgery, 1997-10, Vol.26 (5), p.376-379</ispartof><rights>1997 Munksgaard International Publishers Ltd.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-4f880e8f87d26b0160d4a17c4c353a4ec37f0340c41d0eb89bbf2776aa7618a03</citedby><cites>FETCH-LOGICAL-c389t-4f880e8f87d26b0160d4a17c4c353a4ec37f0340c41d0eb89bbf2776aa7618a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0901502797808016$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2818637$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9327291$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ong'uti, Meshach N.</creatorcontrib><creatorcontrib>Cruchley, Alan T.</creatorcontrib><creatorcontrib>Howells, Gareth L.</creatorcontrib><creatorcontrib>Williams, David M.</creatorcontrib><title>Ki-67 antigen in ameloblastomas: correlation with clinical and histological parameters in 54 cases from Kenya</title><title>International journal of oral and maxillofacial surgery</title><addtitle>Int J Oral Maxillofac Surg</addtitle><description>The aim of this study was to assess the cell proliferation in ameloblastomas and to correlate this with clinical features and histology. Immunohistochemistry with Ki-67 monoclonal antibody was performed on fresh tissue from 54 ameloblastomas. A labelling index (LI) was calculated by expressing the percentage of Ki-67 positive cells. There was no significant correlation between LI and clinical features: age, sex or tumour size. Follicular ameloblastomas had significantly higher LI (5.0±0.5; mean±
sem) than plexiform tumours (3.2±0.6;
P<0.05). Plexiform ameloblastomas from the anterior mandible had a significantly lower LI (1.8±0.5) than those from the posterior (3.9±0.8;
P<0.05). LI was higher in squamous arcades (6.4±3.1%) than in epithelial cords and cysts (1.4±1.3%
P<0.001). These results suggest that LI correlates most closely with the histological pattern of the epithelium of ameloblastoma, both within and between different tumours.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>ameloblastoma</subject><subject>Ameloblastoma - classification</subject><subject>Ameloblastoma - pathology</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Cell Division</subject><subject>Cell Nucleus - ultrastructure</subject><subject>Child</subject><subject>Cysts - pathology</subject><subject>Dentistry</subject><subject>Ent. Stomatology</subject><subject>Epithelium - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>immunohistochemistry</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kenya</subject><subject>Ki-67</subject><subject>Ki-67 Antigen - analysis</subject><subject>Male</subject><subject>Mandibular Neoplasms - pathology</subject><subject>Maxillary Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Sex Factors</subject><issn>0901-5027</issn><issn>1399-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKtvCT6jkA0L0kDKOk9jmUqGKj6qVegDO1sSZtEaJvdhZUP99vR_aKyfLnued8TyMnQu4FCC6jz_AgKhaqNUHoy406HLrXrCVkMZUADW8ZKsj8pqd5vwbAIzU6oSdGFmr2ogVm2991SmOYfEPFLgPHGeaYj9hXuKM-RN3MSWacPEx8H9-eeRu8sE7nEpo4I--cFN82D2sMZX0QilvG7UNd5gp8zHFmd9SeMI37NWIU6a3h_OM_fr65ef19-ru_tvN9ee7ykltlqoZtQbSo1ZD3fVlWRgaFMo1TrYSG3JSjSAbcI0YgHpt-n6sleoQVSc0gjxj7_d91yn-2VBe7Oyzo2nCQHGTrSr7GzBtAds96FLMOdFo18nPmJ6sALvVbHea7dahNcruNNuu5M4PAzb9TMMxdfBa6u8OdczFzJgwOJ-PWK2F7qQq2NUeoyLjr6dks_MUHA0-kVvsEP1_PvIMRy-ZXg</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Ong'uti, Meshach N.</creator><creator>Cruchley, Alan T.</creator><creator>Howells, Gareth L.</creator><creator>Williams, David M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971001</creationdate><title>Ki-67 antigen in ameloblastomas: correlation with clinical and histological parameters in 54 cases from Kenya</title><author>Ong'uti, Meshach N. ; Cruchley, Alan T. ; Howells, Gareth L. ; Williams, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-4f880e8f87d26b0160d4a17c4c353a4ec37f0340c41d0eb89bbf2776aa7618a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>ameloblastoma</topic><topic>Ameloblastoma - classification</topic><topic>Ameloblastoma - pathology</topic><topic>Antibodies, Monoclonal</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Cell Nucleus - ultrastructure</topic><topic>Child</topic><topic>Cysts - pathology</topic><topic>Dentistry</topic><topic>Ent. Stomatology</topic><topic>Epithelium - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>immunohistochemistry</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kenya</topic><topic>Ki-67</topic><topic>Ki-67 Antigen - analysis</topic><topic>Male</topic><topic>Mandibular Neoplasms - pathology</topic><topic>Maxillary Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ong'uti, Meshach N.</creatorcontrib><creatorcontrib>Cruchley, Alan T.</creatorcontrib><creatorcontrib>Howells, Gareth L.</creatorcontrib><creatorcontrib>Williams, David M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ong'uti, Meshach N.</au><au>Cruchley, Alan T.</au><au>Howells, Gareth L.</au><au>Williams, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ki-67 antigen in ameloblastomas: correlation with clinical and histological parameters in 54 cases from Kenya</atitle><jtitle>International journal of oral and maxillofacial surgery</jtitle><addtitle>Int J Oral Maxillofac Surg</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>26</volume><issue>5</issue><spage>376</spage><epage>379</epage><pages>376-379</pages><issn>0901-5027</issn><eissn>1399-0020</eissn><coden>IJOSE9</coden><abstract>The aim of this study was to assess the cell proliferation in ameloblastomas and to correlate this with clinical features and histology. Immunohistochemistry with Ki-67 monoclonal antibody was performed on fresh tissue from 54 ameloblastomas. A labelling index (LI) was calculated by expressing the percentage of Ki-67 positive cells. There was no significant correlation between LI and clinical features: age, sex or tumour size. Follicular ameloblastomas had significantly higher LI (5.0±0.5; mean±
sem) than plexiform tumours (3.2±0.6;
P<0.05). Plexiform ameloblastomas from the anterior mandible had a significantly lower LI (1.8±0.5) than those from the posterior (3.9±0.8;
P<0.05). LI was higher in squamous arcades (6.4±3.1%) than in epithelial cords and cysts (1.4±1.3%
P<0.001). These results suggest that LI correlates most closely with the histological pattern of the epithelium of ameloblastoma, both within and between different tumours.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>9327291</pmid><doi>10.1016/S0901-5027(97)80801-6</doi><tpages>4</tpages></addata></record> |
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| ispartof | International journal of oral and maxillofacial surgery, 1997-10, Vol.26 (5), p.376-379 |
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| subjects | Adolescent Adult Age Factors Aged ameloblastoma Ameloblastoma - classification Ameloblastoma - pathology Antibodies, Monoclonal Biological and medical sciences Cell Division Cell Nucleus - ultrastructure Child Cysts - pathology Dentistry Ent. Stomatology Epithelium - pathology Female Humans Immunoenzyme Techniques immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Kenya Ki-67 Ki-67 Antigen - analysis Male Mandibular Neoplasms - pathology Maxillary Neoplasms - pathology Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Sex Factors |
| title | Ki-67 antigen in ameloblastomas: correlation with clinical and histological parameters in 54 cases from Kenya |
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