Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration
Cellular migration is critically dependent on an interplay between forces of attachment and detachment. Recent studies show that the serine protease urokinase and its major inhibitor and receptor regulate the adhesive properties of integrins, at least in part through initiation of cellular signals....
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| Veröffentlicht in: | Current opinion in cell biology 1997-10, Vol.9 (5), p.714-724 |
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| container_title | Current opinion in cell biology |
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| creator | Chapman, Harold A |
| description | Cellular migration is critically dependent on an interplay between forces of attachment and detachment. Recent studies show that the serine protease urokinase and its major inhibitor and receptor regulate the adhesive properties of integrins, at least in part through initiation of cellular signals. These new functions for an old protease system imply intricate connections between proteolysis and adhesion that operate at the cell surface to regulate migration. |
| doi_str_mv | 10.1016/S0955-0674(97)80126-3 |
| format | Article |
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These new functions for an old protease system imply intricate connections between proteolysis and adhesion that operate at the cell surface to regulate migration.</description><subject>Animals</subject><subject>Cell Adhesion - physiology</subject><subject>Cell Movement - physiology</subject><subject>Humans</subject><subject>Integrins - physiology</subject><subject>Plasminogen Activators - physiology</subject><subject>Receptors, Cell Surface - physiology</subject><subject>Receptors, Urokinase Plasminogen Activator</subject><issn>0955-0674</issn><issn>1879-0410</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1rFTEQhoMo9Vj9CYW9EgW3TjabZHMlpfhRKFhQr-M0mT2N7CY1ySn037t7zqG3Xs0w7ztfD2NnHM45cPXxBxgpW1C6f2f0-wF4p1rxjG34oE0LPYfnbPNkeclelfIHABR05oSdGCFg0GrDft9MWOYQ05Zig66GB6wplw9NiJW2OcQlxeibekeNSyn7ELGSbzJtdxPWkGKTxsbRNDXo76ishdU_h23ey6_ZixGnQm-O8ZT9-vL55-W39vr716vLi-vW9VLWthNeKZIoNRo-jiiAOiPBjFxLr1F12mFvjO5vJToBnGvsOwCvOtK9GlCcsreHufc5_d1RqXYOZb0LI6VdsdqIbhC9WozyYHQ5lZJptPc5zJgfLQe7krV7snbFZo22e7JWLH1nxwW725n8U9cR5aJ_Oui0fPkQKNviAkVHPmRy1foU_rPhH7quiMg</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Chapman, Harold A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971001</creationdate><title>Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration</title><author>Chapman, Harold A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-23d66e5a57a91ffa30e29509f175d7a627ca49974b5ac30117a4200d62e7468a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Cell Adhesion - physiology</topic><topic>Cell Movement - physiology</topic><topic>Humans</topic><topic>Integrins - physiology</topic><topic>Plasminogen Activators - physiology</topic><topic>Receptors, Cell Surface - physiology</topic><topic>Receptors, Urokinase Plasminogen Activator</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chapman, Harold A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chapman, Harold A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration</atitle><jtitle>Current opinion in cell biology</jtitle><addtitle>Curr Opin Cell Biol</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>9</volume><issue>5</issue><spage>714</spage><epage>724</epage><pages>714-724</pages><issn>0955-0674</issn><eissn>1879-0410</eissn><abstract>Cellular migration is critically dependent on an interplay between forces of attachment and detachment. 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| ispartof | Current opinion in cell biology, 1997-10, Vol.9 (5), p.714-724 |
| issn | 0955-0674 1879-0410 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Cell Adhesion - physiology Cell Movement - physiology Humans Integrins - physiology Plasminogen Activators - physiology Receptors, Cell Surface - physiology Receptors, Urokinase Plasminogen Activator |
| title | Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration |
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