The effect of hyaluronic acid on experimental temporomandibular joint osteoarthrosis in the sheep
Purpose The purpose of this study was to test the effect of repeated injections of hyaluronic acid (HA) on the sheep model of osteoarthrotic temporomandibular joint (TMJ) disease. Materials and Methods Bilateral Osteoarthrosis (OA) was induced in the TMJs of six sheep. HA was injected into one joint...
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| Veröffentlicht in: | Journal of oral and maxillofacial surgery 1997-10, Vol.55 (10), p.1114-1119 |
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| creator | Neo, Hisashi Ishimaru, Jun-Ichi Kurita, Kenichi Goss, Alastair N |
| description | Purpose
The purpose of this study was to test the effect of repeated injections of hyaluronic acid (HA) on the sheep model of osteoarthrotic temporomandibular joint (TMJ) disease.
Materials and Methods
Bilateral Osteoarthrosis (OA) was induced in the TMJs of six sheep. HA was injected into one joint on 7, 10, 14, 17, and 21 days postoperatively. Normal saline was injected into the contralateral joint. Three sheep were killed at 1 month and 3 at 3 months. The joints were removed and examined macroscopically and histologically. A special scoring system was applied following the modified Mankin's score to evaluate the histologic changes.
Results
The control group showed severe osteoarthrotic changes in the condyle, deviation in form from normal morphology, and marked marrow fibrosis. The HA-treated group showed less deviation from normal condylar morphology. The histologic scores at 1 month were HA 12.6, control 24.2 (
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| doi_str_mv | 10.1016/S0278-2391(97)90293-7 |
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The purpose of this study was to test the effect of repeated injections of hyaluronic acid (HA) on the sheep model of osteoarthrotic temporomandibular joint (TMJ) disease.
Materials and Methods
Bilateral Osteoarthrosis (OA) was induced in the TMJs of six sheep. HA was injected into one joint on 7, 10, 14, 17, and 21 days postoperatively. Normal saline was injected into the contralateral joint. Three sheep were killed at 1 month and 3 at 3 months. The joints were removed and examined macroscopically and histologically. A special scoring system was applied following the modified Mankin's score to evaluate the histologic changes.
Results
The control group showed severe osteoarthrotic changes in the condyle, deviation in form from normal morphology, and marked marrow fibrosis. The HA-treated group showed less deviation from normal condylar morphology. The histologic scores at 1 month were HA 12.6, control 24.2 (
P <.001), and at 3 months were HA 6.9, control 18.9 (
P < .001). There was a significant difference in osteoarthrotic changes between HA-treated and control TMJs, with the HA-treated TMJs having less severe changes.
Conclusion
Repeated intraarticular injections of HA into a sheep TMJ with experimentally induced OA minimizes the extent of osteoarthrotic change when compared with the control joint. Thus, HA may have a role in preventing the progression of TMJ OA.</description><identifier>ISSN: 0278-2391</identifier><identifier>EISSN: 1531-5053</identifier><identifier>DOI: 10.1016/S0278-2391(97)90293-7</identifier><identifier>PMID: 9331236</identifier><identifier>CODEN: JOMSDA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Anti-Inflammatory Agents - therapeutic use ; Biological and medical sciences ; Cartilage, Articular - pathology ; Dentistry ; Disease Models, Animal ; Disease Progression ; Ent. Stomatology ; Hyaluronic Acid - administration & dosage ; Hyaluronic Acid - therapeutic use ; Injections, Intra-Articular ; Male ; Mandibular Condyle - pathology ; Medical sciences ; Osteoarthritis - drug therapy ; Osteoarthritis - pathology ; Pharmacology. Drug treatments ; Primary Myelofibrosis - pathology ; Sheep ; Temporal Bone - pathology ; Temporomandibular Joint Disc - pathology ; Temporomandibular Joint Disorders - drug therapy ; Temporomandibular Joint Disorders - pathology</subject><ispartof>Journal of oral and maxillofacial surgery, 1997-10, Vol.55 (10), p.1114-1119</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-ea4476407a4b9d44500c8969b1ae10cbfb30a06702e4bc32caf64e2b95a2ac2a3</citedby><cites>FETCH-LOGICAL-c486t-ea4476407a4b9d44500c8969b1ae10cbfb30a06702e4bc32caf64e2b95a2ac2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0278-2391(97)90293-7$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2846280$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9331236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Neo, Hisashi</creatorcontrib><creatorcontrib>Ishimaru, Jun-Ichi</creatorcontrib><creatorcontrib>Kurita, Kenichi</creatorcontrib><creatorcontrib>Goss, Alastair N</creatorcontrib><title>The effect of hyaluronic acid on experimental temporomandibular joint osteoarthrosis in the sheep</title><title>Journal of oral and maxillofacial surgery</title><addtitle>J Oral Maxillofac Surg</addtitle><description>Purpose
The purpose of this study was to test the effect of repeated injections of hyaluronic acid (HA) on the sheep model of osteoarthrotic temporomandibular joint (TMJ) disease.
Materials and Methods
Bilateral Osteoarthrosis (OA) was induced in the TMJs of six sheep. HA was injected into one joint on 7, 10, 14, 17, and 21 days postoperatively. Normal saline was injected into the contralateral joint. Three sheep were killed at 1 month and 3 at 3 months. The joints were removed and examined macroscopically and histologically. A special scoring system was applied following the modified Mankin's score to evaluate the histologic changes.
Results
The control group showed severe osteoarthrotic changes in the condyle, deviation in form from normal morphology, and marked marrow fibrosis. The HA-treated group showed less deviation from normal condylar morphology. The histologic scores at 1 month were HA 12.6, control 24.2 (
P <.001), and at 3 months were HA 6.9, control 18.9 (
P < .001). There was a significant difference in osteoarthrotic changes between HA-treated and control TMJs, with the HA-treated TMJs having less severe changes.
Conclusion
Repeated intraarticular injections of HA into a sheep TMJ with experimentally induced OA minimizes the extent of osteoarthrotic change when compared with the control joint. Thus, HA may have a role in preventing the progression of TMJ OA.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cartilage, Articular - pathology</subject><subject>Dentistry</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Ent. Stomatology</subject><subject>Hyaluronic Acid - administration & dosage</subject><subject>Hyaluronic Acid - therapeutic use</subject><subject>Injections, Intra-Articular</subject><subject>Male</subject><subject>Mandibular Condyle - pathology</subject><subject>Medical sciences</subject><subject>Osteoarthritis - drug therapy</subject><subject>Osteoarthritis - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Primary Myelofibrosis - pathology</subject><subject>Sheep</subject><subject>Temporal Bone - pathology</subject><subject>Temporomandibular Joint Disc - pathology</subject><subject>Temporomandibular Joint Disorders - drug therapy</subject><subject>Temporomandibular Joint Disorders - pathology</subject><issn>0278-2391</issn><issn>1531-5053</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQhS0EKpfCT6jkBUJ0EfDb8QpVFS-pEgvK2po4E11XSRzspKL_Hrf36m67msV8Zx7nEHLB2SfOuPn8mwnbNkI6_tHZS8eEk419QXZcS95opuVLsjshr8mbUu4Y41xbc0bOnJRcSLMjcLtHisOAYaVpoPsHGLec5hgohNjTNFP8t2COE84rjHTFaUk5TTD3sdtGyPQuxblKy4oJ8rrPqcRC40zXOrfsEZe35NUAY8F3x3pO_nz7env9o7n59f3n9dVNE1Rr1gZBKWsUs6A61yulGQutM67jgJyFbugkA2YsE6i6IEWAwSgUndMgIAiQ5-TDYe6S098Ny-qnWAKOI8yYtuKtk8I4YZ4FuRG81VZXUB_AUL8qGQe_VCMgP3jO_GMG_ikD_2iwd9Y_ZeBt1V0cF2zdhP1JdTS99t8f-1ACjEOGOcRywkSrjGhZxb4cMKyu3UfMvoSIc8A-5hqX71N85pD_3aukdQ</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Neo, Hisashi</creator><creator>Ishimaru, Jun-Ichi</creator><creator>Kurita, Kenichi</creator><creator>Goss, Alastair N</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>19971001</creationdate><title>The effect of hyaluronic acid on experimental temporomandibular joint osteoarthrosis in the sheep</title><author>Neo, Hisashi ; Ishimaru, Jun-Ichi ; Kurita, Kenichi ; Goss, Alastair N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-ea4476407a4b9d44500c8969b1ae10cbfb30a06702e4bc32caf64e2b95a2ac2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cartilage, Articular - pathology</topic><topic>Dentistry</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Ent. Stomatology</topic><topic>Hyaluronic Acid - administration & dosage</topic><topic>Hyaluronic Acid - therapeutic use</topic><topic>Injections, Intra-Articular</topic><topic>Male</topic><topic>Mandibular Condyle - pathology</topic><topic>Medical sciences</topic><topic>Osteoarthritis - drug therapy</topic><topic>Osteoarthritis - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Primary Myelofibrosis - pathology</topic><topic>Sheep</topic><topic>Temporal Bone - pathology</topic><topic>Temporomandibular Joint Disc - pathology</topic><topic>Temporomandibular Joint Disorders - drug therapy</topic><topic>Temporomandibular Joint Disorders - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Neo, Hisashi</creatorcontrib><creatorcontrib>Ishimaru, Jun-Ichi</creatorcontrib><creatorcontrib>Kurita, Kenichi</creatorcontrib><creatorcontrib>Goss, Alastair N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of oral and maxillofacial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Neo, Hisashi</au><au>Ishimaru, Jun-Ichi</au><au>Kurita, Kenichi</au><au>Goss, Alastair N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of hyaluronic acid on experimental temporomandibular joint osteoarthrosis in the sheep</atitle><jtitle>Journal of oral and maxillofacial surgery</jtitle><addtitle>J Oral Maxillofac Surg</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>55</volume><issue>10</issue><spage>1114</spage><epage>1119</epage><pages>1114-1119</pages><issn>0278-2391</issn><eissn>1531-5053</eissn><coden>JOMSDA</coden><abstract>Purpose
The purpose of this study was to test the effect of repeated injections of hyaluronic acid (HA) on the sheep model of osteoarthrotic temporomandibular joint (TMJ) disease.
Materials and Methods
Bilateral Osteoarthrosis (OA) was induced in the TMJs of six sheep. HA was injected into one joint on 7, 10, 14, 17, and 21 days postoperatively. Normal saline was injected into the contralateral joint. Three sheep were killed at 1 month and 3 at 3 months. The joints were removed and examined macroscopically and histologically. A special scoring system was applied following the modified Mankin's score to evaluate the histologic changes.
Results
The control group showed severe osteoarthrotic changes in the condyle, deviation in form from normal morphology, and marked marrow fibrosis. The HA-treated group showed less deviation from normal condylar morphology. The histologic scores at 1 month were HA 12.6, control 24.2 (
P <.001), and at 3 months were HA 6.9, control 18.9 (
P < .001). There was a significant difference in osteoarthrotic changes between HA-treated and control TMJs, with the HA-treated TMJs having less severe changes.
Conclusion
Repeated intraarticular injections of HA into a sheep TMJ with experimentally induced OA minimizes the extent of osteoarthrotic change when compared with the control joint. Thus, HA may have a role in preventing the progression of TMJ OA.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9331236</pmid><doi>10.1016/S0278-2391(97)90293-7</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Cartilage, Articular - pathology Dentistry Disease Models, Animal Disease Progression Ent. Stomatology Hyaluronic Acid - administration & dosage Hyaluronic Acid - therapeutic use Injections, Intra-Articular Male Mandibular Condyle - pathology Medical sciences Osteoarthritis - drug therapy Osteoarthritis - pathology Pharmacology. Drug treatments Primary Myelofibrosis - pathology Sheep Temporal Bone - pathology Temporomandibular Joint Disc - pathology Temporomandibular Joint Disorders - drug therapy Temporomandibular Joint Disorders - pathology |
| title | The effect of hyaluronic acid on experimental temporomandibular joint osteoarthrosis in the sheep |
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