Suppression of extracellular signals and cell proliferation through EGF receptor binding by (−)-epigallocatechin gallate in human A431 epidermoid carcinoma cells

Tea polyphenols are known to inhibit a wide variety of enzymatic activities associated with cell proliferation and tumor progression. The molecular mechanisms of antiproliferation are remained to be elucidated. In this study, we investigated the effects of the major tea polyphenol (−)‐epigallocatech...

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Veröffentlicht in:	Journal of cellular biochemistry 1997-10, Vol.67 (1), p.55-65
Hauptverfasser:	Liang, Yu-Chih, Lin-shiau, Shoei-Yn, Chen, Chieh-Fu, Lin, Jen-Kun
Format:	Artikel
Sprache:	eng
Schlagworte:	(−)-epigallocatechin gallate Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Carcinoma, Squamous Cell - metabolism Catechin - analogs & derivatives Catechin - metabolism Catechin - pharmacology Cell Division - drug effects DNA, Neoplasm - biosynthesis Epidermal Growth Factor - metabolism epidermal growth factor receptor fibroblast growth factor Humans Ligands Phosphotyrosine - analysis platelet-derived growth factor protein kinase A protein kinase C protein tyrosine kinases Receptor Protein-Tyrosine Kinases - metabolism receptor tyrosine kinases Receptor, Epidermal Growth Factor - drug effects Receptor, Epidermal Growth Factor - metabolism Receptors, Fibroblast Growth Factor - metabolism Receptors, Platelet-Derived Growth Factor - metabolism Signal Transduction - physiology Tea - chemistry Tumor Cells, Cultured
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