Genetic alterations accumulate during cervical tumorigenesis and indicate a common origin for multifocal lesions

Carcinomas of the uterine cervix are thought to arise from preinvasive dysplastic lesions, termed cervical intraepithelial neoplasias (CIN), grades I-III. Patients may present clinically with two or more distinct lesions of differing histological severity; however, the genesis of these multifocal le...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-10, Vol.57 (19), p.4171-4176
Hauptverfasser:	LARSON, A. A, LIAO, S.-Y, STANBRIDGE, E. J, CAVENEE, W. K, HAMPTON, G. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Transformation, Neoplastic - genetics Cervical Intraepithelial Neoplasia - etiology Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - pathology Cervical Intraepithelial Neoplasia - virology Disease Progression DNA Probes, HPV Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Loss of Heterozygosity Medical sciences Microsatellite Repeats Neoplasms, Multiple Primary - etiology Neoplasms, Multiple Primary - genetics Neoplasms, Multiple Primary - pathology Neoplasms, Multiple Primary - virology Papillomaviridae - classification Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - complications Retrospective Studies Tumor Virus Infections - complications Tumors Uterine Cervical Dysplasia - genetics Uterine Cervical Dysplasia - pathology Uterine Cervical Dysplasia - virology Uterine Cervical Neoplasms - etiology Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - virology
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