Graves' disease: An analysis of thyroid hormone levels and hyperthyroid signs and symptoms
Assessment of disease severity for patients with hyperthyroidism involves clinical evaluation and laboratory testing. To determine if there is a correlation between symptoms and thyroid function test results, we prospectively studied hyperthyroid patients using a standardized symptom rating scale an...
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| Veröffentlicht in: | The American journal of medicine 1989-11, Vol.87 (5), p.558-561 |
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| container_title | The American journal of medicine |
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| creator | Trzepacz, Paula T. Klein, Irwin Roberts, Michelle Greenhouse, Joel Levey, Gerald S. |
| description | Assessment of disease severity for patients with hyperthyroidism involves clinical evaluation and laboratory testing. To determine if there is a correlation between symptoms and thyroid function test results, we prospectively studied hyperthyroid patients using a standardized symptom rating scale and serum thyroid function parameters.
We examined 25 patients with untreated, newly diagnosed Graves' disease using the Hyperthyroid Symptom Scale (HSS) and serum levels of thyroxine (T
4), triiodothyronine (T
3) relative insulin area (RIA), and estimates of free thyroxine index (FTI). In addition, we compared thyroid hormone levels with standard measures of depression and anxiety in these patients.
When regression analyses controlling for age were performed, none of these symptom ratings were associated with FTI or T
3 RIA. The HSS was correlated with goiter size and anxiety ratings and was inversely correlated with age.
The present study suggests that there is no relationship between the clinical assessment of disease severity and serum levels of thyroid hormone in untreated Graves' disease. |
| doi_str_mv | 10.1016/S0002-9343(89)80614-X |
| format | Article |
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We examined 25 patients with untreated, newly diagnosed Graves' disease using the Hyperthyroid Symptom Scale (HSS) and serum levels of thyroxine (T
4), triiodothyronine (T
3) relative insulin area (RIA), and estimates of free thyroxine index (FTI). In addition, we compared thyroid hormone levels with standard measures of depression and anxiety in these patients.
When regression analyses controlling for age were performed, none of these symptom ratings were associated with FTI or T
3 RIA. The HSS was correlated with goiter size and anxiety ratings and was inversely correlated with age.
The present study suggests that there is no relationship between the clinical assessment of disease severity and serum levels of thyroid hormone in untreated Graves' disease.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/S0002-9343(89)80614-X</identifier><identifier>PMID: 2816972</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Female ; Graves Disease - blood ; Humans ; Hyperthyroidism - metabolism ; Male ; Middle Aged ; Prospective Studies ; Thyroid Function Tests ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>The American journal of medicine, 1989-11, Vol.87 (5), p.558-561</ispartof><rights>1989 Reed Publishing USA</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-e2449a489d8d1cf98501d6b4f3d0b8993d911c4cabcef82184dc2e26915b268d3</citedby><cites>FETCH-LOGICAL-c391t-e2449a489d8d1cf98501d6b4f3d0b8993d911c4cabcef82184dc2e26915b268d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9343(89)80614-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2816972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trzepacz, Paula T.</creatorcontrib><creatorcontrib>Klein, Irwin</creatorcontrib><creatorcontrib>Roberts, Michelle</creatorcontrib><creatorcontrib>Greenhouse, Joel</creatorcontrib><creatorcontrib>Levey, Gerald S.</creatorcontrib><title>Graves' disease: An analysis of thyroid hormone levels and hyperthyroid signs and symptoms</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>Assessment of disease severity for patients with hyperthyroidism involves clinical evaluation and laboratory testing. To determine if there is a correlation between symptoms and thyroid function test results, we prospectively studied hyperthyroid patients using a standardized symptom rating scale and serum thyroid function parameters.
We examined 25 patients with untreated, newly diagnosed Graves' disease using the Hyperthyroid Symptom Scale (HSS) and serum levels of thyroxine (T
4), triiodothyronine (T
3) relative insulin area (RIA), and estimates of free thyroxine index (FTI). In addition, we compared thyroid hormone levels with standard measures of depression and anxiety in these patients.
When regression analyses controlling for age were performed, none of these symptom ratings were associated with FTI or T
3 RIA. The HSS was correlated with goiter size and anxiety ratings and was inversely correlated with age.
The present study suggests that there is no relationship between the clinical assessment of disease severity and serum levels of thyroid hormone in untreated Graves' disease.</description><subject>Adult</subject><subject>Female</subject><subject>Graves Disease - blood</subject><subject>Humans</subject><subject>Hyperthyroidism - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Thyroid Function Tests</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LxDAQxYMouq7-CUJPfhyqSdqmiRcR8QsEDyqIl5AmU420zZrpLvS_t-uuXj0NM--9efAj5IDRU0aZOHuilPJUZXl2LNWJpILl6esGmbCiKNKSCb5JJn-WHbKL-DmuVBVim2xzyYQq-YS83UazADxKnEcwCOfJZZeYzjQDekxCnfQfQwzeJR8htqGDpIEFNDhaxtMwg_iro3_vVmcc2lkfWtwjW7VpEPbXc0pebq6fr-7Sh8fb-6vLh9RmivUp8DxXJpfKScdsrWRBmRNVXmeOVlKpzCnGbG5NZaGWnMncWQ5cKFZUXEiXTcnh6u8shq85YK9bjxaaxnQQ5qhLlfGspOJfIytKIZaNU1KsjDYGxAi1nkXfmjhoRvUSvv6Br5dktVT6B75-HXMH64J51YL7S61pj_rFSh8JwsJD1Gg9dBacj2B77YL_p-Ebx9WUyw</recordid><startdate>19891101</startdate><enddate>19891101</enddate><creator>Trzepacz, Paula T.</creator><creator>Klein, Irwin</creator><creator>Roberts, Michelle</creator><creator>Greenhouse, Joel</creator><creator>Levey, Gerald S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19891101</creationdate><title>Graves' disease: An analysis of thyroid hormone levels and hyperthyroid signs and symptoms</title><author>Trzepacz, Paula T. ; Klein, Irwin ; Roberts, Michelle ; Greenhouse, Joel ; Levey, Gerald S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-e2449a489d8d1cf98501d6b4f3d0b8993d911c4cabcef82184dc2e26915b268d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Female</topic><topic>Graves Disease - blood</topic><topic>Humans</topic><topic>Hyperthyroidism - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Thyroid Function Tests</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trzepacz, Paula T.</creatorcontrib><creatorcontrib>Klein, Irwin</creatorcontrib><creatorcontrib>Roberts, Michelle</creatorcontrib><creatorcontrib>Greenhouse, Joel</creatorcontrib><creatorcontrib>Levey, Gerald S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trzepacz, Paula T.</au><au>Klein, Irwin</au><au>Roberts, Michelle</au><au>Greenhouse, Joel</au><au>Levey, Gerald S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Graves' disease: An analysis of thyroid hormone levels and hyperthyroid signs and symptoms</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1989-11-01</date><risdate>1989</risdate><volume>87</volume><issue>5</issue><spage>558</spage><epage>561</epage><pages>558-561</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>Assessment of disease severity for patients with hyperthyroidism involves clinical evaluation and laboratory testing. To determine if there is a correlation between symptoms and thyroid function test results, we prospectively studied hyperthyroid patients using a standardized symptom rating scale and serum thyroid function parameters.
We examined 25 patients with untreated, newly diagnosed Graves' disease using the Hyperthyroid Symptom Scale (HSS) and serum levels of thyroxine (T
4), triiodothyronine (T
3) relative insulin area (RIA), and estimates of free thyroxine index (FTI). In addition, we compared thyroid hormone levels with standard measures of depression and anxiety in these patients.
When regression analyses controlling for age were performed, none of these symptom ratings were associated with FTI or T
3 RIA. The HSS was correlated with goiter size and anxiety ratings and was inversely correlated with age.
The present study suggests that there is no relationship between the clinical assessment of disease severity and serum levels of thyroid hormone in untreated Graves' disease.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2816972</pmid><doi>10.1016/S0002-9343(89)80614-X</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9343 |
| ispartof | The American journal of medicine, 1989-11, Vol.87 (5), p.558-561 |
| issn | 0002-9343 1555-7162 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Female Graves Disease - blood Humans Hyperthyroidism - metabolism Male Middle Aged Prospective Studies Thyroid Function Tests Thyroxine - blood Triiodothyronine - blood |
| title | Graves' disease: An analysis of thyroid hormone levels and hyperthyroid signs and symptoms |
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