Glucocorticoid/oxysterol-induced DNA lysis in human leukemic cells

Both glucocorticoids and oxysterols, steroids with quite different known transduction pathways, cause the death of lymphoid cells. Dual TUNEL/propidium iodide assays on sensitive human leukemic CEM-C7 clones treated with either steroid were clearly positive by 48 h, consistent with apoptosis. Both s...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 1997-04, Vol.61 (1), p.35-45
Hauptverfasser:	Johnson, Betty H., Ayala-Torres, Sylvette, Chan, Lee-Nien L., El-Naghy, Mohamed, Thompson, E.Brad
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cell Division Chemotherapy Dexamethasone - pharmacology DNA Fragmentation - drug effects DNA, Neoplasm - analysis Glucocorticoids - pharmacology Humans Hydroxycholesterols - pharmacology Medical sciences Pharmacology. Drug treatments Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Tumor Cells, Cultured
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