Transient immunosuppression with FK506 permits long‐term expression of therapeutic genes introduced into the liver using recombinant adenoviruses in the rat

The host immune response limits the duration of expression of adenovirally transduced genes and precludes long‐term gene expression upon re‐administration of the virus. In this study we wished to evaluate whether short‐term immunosuppression of the host, at the time of recombinant virus administrati...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 1997-10, Vol.26 (4), p.949-956
Hauptverfasser:	Ilan, Y, Jona, V K, Sengupta, K, Davidson, A, Horwitz, M S, Roy‐Chowdhury, N, Roy‐Chowdhury, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Alanine Transaminase - blood Animals Bilirubin - analogs & derivatives Bilirubin - metabolism Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Gene therapy Genetic Therapy Glucuronosyltransferase - genetics Health. Pharmaceutical industry Humans Immunosuppressive Agents - pharmacology Industrial applications and implications. Economical aspects Lac Operon Liver - metabolism Liver - pathology Rats Rats, Gunn Rats, Wistar T-Lymphocytes, Cytotoxic - immunology Tacrolimus - pharmacology
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