ATP-Induced Killing of Mycobacteria by Human Macrophages Is Mediated by Purinergic P2Z(P2X 7) Receptors

The death of BCG-infected human macrophages induced in vitro by ligation of surface CD95 (Fas), CD69, or complement-mediated lysis was shown not to result in the death of intracellular mycobacteria, whereas exposure to extracellular ATP initiated both macrophage death and killed the intracellular ba...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 1997-09, Vol.7 (3), p.433-444
Hauptverfasser:	Lammas, D.A., Stober, C., Harvey, C.J., Kendrick, N., Panchalingam, S., Kumararatne, D.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - pharmacology Cells, Cultured Humans Macrophages - cytology Macrophages - microbiology Macrophages - physiology Mycobacterium Mycobacterium bovis - immunology Nitrogen - metabolism Nitrogen - physiology Phagocytosis Reactive Oxygen Species - metabolism Reactive Oxygen Species - physiology Receptors, Purinergic P2 - physiology Receptors, Purinergic P2X7
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