Aminoglycoside resistance. Enzymatic mechanisms in clinical bacterial strains in Slovakia during the last decade
We determined the importance and dissemination of enzymatic mechanisms of aminoglycoside resistance in 239 gentamicin-resistant strains of Gram-negative bacilli isolated in Slovakia during the past decade. Over the past 5 years, the resistance to tobramycin has risen by 1.1%, to netilmicin by 27.4%,...
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| Veröffentlicht in: | FEMS immunology and medical microbiology 1997-09, Vol.19 (1), p.89-94 |
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| container_title | FEMS immunology and medical microbiology |
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| creator | Kallová, Janka Kettner, Milan Mačičková, Tatiana Milošovič, Peter Langšádl, Leon |
| description | We determined the importance and dissemination of enzymatic mechanisms of aminoglycoside resistance in 239 gentamicin-resistant strains of Gram-negative bacilli isolated in Slovakia during the past decade. Over the past 5 years, the resistance to tobramycin has risen by 1.1%, to netilmicin by 27.4%, to amikacin by 78.3%, and resistance to isepamicin was high too (81.9%). Sixteen different aminoglycoside-modifying enzymes were detected and their significance for resistance to aminoglycosides was confirmed. It is evident that within the past 5 years gentamicin-resistant bacteria have obtained genetic information on resistance to the other aminoglycosides tested and the percentage of strains with different enzyme combinations has risen. These observations confirm the continuously increasing complexity of antibiotic resistance in clinical bacterial isolates under study in Slovakia during the last decade. |
| doi_str_mv | 10.1016/S0928-8244(97)00072-2 |
| format | Article |
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Enzymatic mechanisms in clinical bacterial strains in Slovakia during the last decade</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Kallová, Janka ; Kettner, Milan ; Mačičková, Tatiana ; Milošovič, Peter ; Langšádl, Leon</creator><creatorcontrib>Kallová, Janka ; Kettner, Milan ; Mačičková, Tatiana ; Milošovič, Peter ; Langšádl, Leon</creatorcontrib><description>We determined the importance and dissemination of enzymatic mechanisms of aminoglycoside resistance in 239 gentamicin-resistant strains of Gram-negative bacilli isolated in Slovakia during the past decade. Over the past 5 years, the resistance to tobramycin has risen by 1.1%, to netilmicin by 27.4%, to amikacin by 78.3%, and resistance to isepamicin was high too (81.9%). Sixteen different aminoglycoside-modifying enzymes were detected and their significance for resistance to aminoglycosides was confirmed. It is evident that within the past 5 years gentamicin-resistant bacteria have obtained genetic information on resistance to the other aminoglycosides tested and the percentage of strains with different enzyme combinations has risen. These observations confirm the continuously increasing complexity of antibiotic resistance in clinical bacterial isolates under study in Slovakia during the last decade.</description><identifier>ISSN: 0928-8244</identifier><identifier>EISSN: 1574-695X</identifier><identifier>DOI: 10.1016/S0928-8244(97)00072-2</identifier><identifier>PMID: 9322073</identifier><language>eng</language><publisher>Oxford: Elsevier B.V</publisher><subject>Aminoglycoside ; Anti-Bacterial Agents - metabolism ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Drug Resistance, Microbial ; Enzymes - genetics ; Enzymes - metabolism ; Gentamicins - metabolism ; Gentamicins - pharmacology ; Gentamicins - therapeutic use ; Gram-negative bacilli ; Gram-Negative Bacteria - drug effects ; Gram-Negative Bacteria - enzymology ; Gram-Negative Bacteria - metabolism ; Gram-Negative Bacterial Infections - drug therapy ; Gram-Negative Bacterial Infections - epidemiology ; Humans ; Medical sciences ; Microbial Sensitivity Tests ; Pharmacology. Drug treatments ; Resistance ; Slovakia - epidemiology</subject><ispartof>FEMS immunology and medical microbiology, 1997-09, Vol.19 (1), p.89-94</ispartof><rights>1997 Federation of European Microbiological Societies</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-9f08689091bd65814e218514636d30f6fa89f1bb796d59d30e07551663a426bd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2862366$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9322073$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kallová, Janka</creatorcontrib><creatorcontrib>Kettner, Milan</creatorcontrib><creatorcontrib>Mačičková, Tatiana</creatorcontrib><creatorcontrib>Milošovič, Peter</creatorcontrib><creatorcontrib>Langšádl, Leon</creatorcontrib><title>Aminoglycoside resistance. Enzymatic mechanisms in clinical bacterial strains in Slovakia during the last decade</title><title>FEMS immunology and medical microbiology</title><addtitle>FEMS Immunol Med Microbiol</addtitle><description>We determined the importance and dissemination of enzymatic mechanisms of aminoglycoside resistance in 239 gentamicin-resistant strains of Gram-negative bacilli isolated in Slovakia during the past decade. Over the past 5 years, the resistance to tobramycin has risen by 1.1%, to netilmicin by 27.4%, to amikacin by 78.3%, and resistance to isepamicin was high too (81.9%). Sixteen different aminoglycoside-modifying enzymes were detected and their significance for resistance to aminoglycosides was confirmed. It is evident that within the past 5 years gentamicin-resistant bacteria have obtained genetic information on resistance to the other aminoglycosides tested and the percentage of strains with different enzyme combinations has risen. These observations confirm the continuously increasing complexity of antibiotic resistance in clinical bacterial isolates under study in Slovakia during the last decade.</description><subject>Aminoglycoside</subject><subject>Anti-Bacterial Agents - metabolism</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Drug Resistance, Microbial</subject><subject>Enzymes - genetics</subject><subject>Enzymes - metabolism</subject><subject>Gentamicins - metabolism</subject><subject>Gentamicins - pharmacology</subject><subject>Gentamicins - therapeutic use</subject><subject>Gram-negative bacilli</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Negative Bacteria - enzymology</subject><subject>Gram-Negative Bacteria - metabolism</subject><subject>Gram-Negative Bacterial Infections - drug therapy</subject><subject>Gram-Negative Bacterial Infections - epidemiology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. Drug treatments</subject><subject>Resistance</subject><subject>Slovakia - epidemiology</subject><issn>0928-8244</issn><issn>1574-695X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rFTEUhoMo9Vr9CYUsRHQxNclMMslKSqkfUHBRBXchk5xpj85krklu4frrzf3gbrvKIe9zPnhfQi44u-SMq493zAjdaNF1703_gTHWi0Y8Iysu-65RRv56TlYn5CV5lfPvCnWGsTNyZlohWN-uyPpqxrjcT1u_ZAxAE2TMxUUPl_Qm_tvOrqCnM_gHFzHPmWKkfsKI3k10cL5AwlrlkhzGvXo3LY_uDzoaNgnjPS0PQCeXCw3gXYDX5MXopgxvju85-fn55sf11-b2-5dv11e3je8EK40ZmVbaMMOHoKTmHQiuJe9Uq0LLRjU6bUY-DL1RQZr6BayXkivVuk6oIbTn5N1h7jotfzeQi50xe5gmF2HZZNtXC5g28kmQK8GN5qqC8gD6tOScYLTrhLNLW8uZ3UVi95HYnd_W9HYfiRW17-K4YDPMEE5dxwyq_vaou1xdHVN1H_MJE1qJVu3WfzpgUF17REg2e4QaVMAEvtiw4BOH_AdNuqgu</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Kallová, Janka</creator><creator>Kettner, Milan</creator><creator>Mačičková, Tatiana</creator><creator>Milošovič, Peter</creator><creator>Langšádl, Leon</creator><general>Elsevier B.V</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>Aminoglycoside resistance. Enzymatic mechanisms in clinical bacterial strains in Slovakia during the last decade</title><author>Kallová, Janka ; Kettner, Milan ; Mačičková, Tatiana ; Milošovič, Peter ; Langšádl, Leon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-9f08689091bd65814e218514636d30f6fa89f1bb796d59d30e07551663a426bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aminoglycoside</topic><topic>Anti-Bacterial Agents - metabolism</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Drug Resistance, Microbial</topic><topic>Enzymes - genetics</topic><topic>Enzymes - metabolism</topic><topic>Gentamicins - metabolism</topic><topic>Gentamicins - pharmacology</topic><topic>Gentamicins - therapeutic use</topic><topic>Gram-negative bacilli</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Negative Bacteria - enzymology</topic><topic>Gram-Negative Bacteria - metabolism</topic><topic>Gram-Negative Bacterial Infections - drug therapy</topic><topic>Gram-Negative Bacterial Infections - epidemiology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. Drug treatments</topic><topic>Resistance</topic><topic>Slovakia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kallová, Janka</creatorcontrib><creatorcontrib>Kettner, Milan</creatorcontrib><creatorcontrib>Mačičková, Tatiana</creatorcontrib><creatorcontrib>Milošovič, Peter</creatorcontrib><creatorcontrib>Langšádl, Leon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEMS immunology and medical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kallová, Janka</au><au>Kettner, Milan</au><au>Mačičková, Tatiana</au><au>Milošovič, Peter</au><au>Langšádl, Leon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aminoglycoside resistance. Enzymatic mechanisms in clinical bacterial strains in Slovakia during the last decade</atitle><jtitle>FEMS immunology and medical microbiology</jtitle><addtitle>FEMS Immunol Med Microbiol</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>19</volume><issue>1</issue><spage>89</spage><epage>94</epage><pages>89-94</pages><issn>0928-8244</issn><eissn>1574-695X</eissn><abstract>We determined the importance and dissemination of enzymatic mechanisms of aminoglycoside resistance in 239 gentamicin-resistant strains of Gram-negative bacilli isolated in Slovakia during the past decade. Over the past 5 years, the resistance to tobramycin has risen by 1.1%, to netilmicin by 27.4%, to amikacin by 78.3%, and resistance to isepamicin was high too (81.9%). Sixteen different aminoglycoside-modifying enzymes were detected and their significance for resistance to aminoglycosides was confirmed. It is evident that within the past 5 years gentamicin-resistant bacteria have obtained genetic information on resistance to the other aminoglycosides tested and the percentage of strains with different enzyme combinations has risen. These observations confirm the continuously increasing complexity of antibiotic resistance in clinical bacterial isolates under study in Slovakia during the last decade.</abstract><cop>Oxford</cop><pub>Elsevier B.V</pub><pmid>9322073</pmid><doi>10.1016/S0928-8244(97)00072-2</doi><tpages>6</tpages></addata></record> |
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| ispartof | FEMS immunology and medical microbiology, 1997-09, Vol.19 (1), p.89-94 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_79320895 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Aminoglycoside Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Drug Resistance, Microbial Enzymes - genetics Enzymes - metabolism Gentamicins - metabolism Gentamicins - pharmacology Gentamicins - therapeutic use Gram-negative bacilli Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - enzymology Gram-Negative Bacteria - metabolism Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - epidemiology Humans Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Resistance Slovakia - epidemiology |
| title | Aminoglycoside resistance. Enzymatic mechanisms in clinical bacterial strains in Slovakia during the last decade |
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