Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography
Positron Emission Tomography (PET) imaging of regional cerebral blood flow (rCBF) provides an in vivo method for studying brain function. We used [15O]H2O PET to assess the effect of antipsychotic medications on rCBF in 17 subjects with schizophrenia. Each subject was scanned while receiving antipsy...
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| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 1997-10, Vol.17 (4), p.230-240 |
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| container_title | Neuropsychopharmacology (New York, N.Y.) |
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| creator | Miller, Del D Andreasen, Nancy C. O'Leary, Daniel S. Rezai, Karim Leonard Watkins, G. Boles Ponto, Laura L. Hichwa, Richard D. |
| description | Positron Emission Tomography (PET) imaging of regional cerebral blood flow (rCBF) provides an in vivo method for studying brain function. We used [15O]H2O PET to assess the effect of antipsychotic medications on rCBF in 17 subjects with schizophrenia. Each subject was scanned while receiving antipsychotic medication, and after having been withdrawn from antipsychotic medication for a 3-week period. The two scans were subtracted from one another, using a within subjects design, and the areas of difference were identified using the Montreal method. Subjects treated with antipsychotic medication had significantly higher rCBF in the left basal ganglia and left fusiform gyrus compared with the “off-medication” condition. Significantly higher relative rCBF in the anterior cingulate, left dorsolateral and inferior frontal cortex, and left and right cerebellum was observed when off antipsychotic medication. Upregulation of dopamine D2 receptors may lead to a regional increase of blood flow and metabolism in the basal ganglia, which may explain recently reported anatomical enlargement in these regions. |
| doi_str_mv | 10.1016/S0893-133X(97)00042-0 |
| format | Article |
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We used [15O]H2O PET to assess the effect of antipsychotic medications on rCBF in 17 subjects with schizophrenia. Each subject was scanned while receiving antipsychotic medication, and after having been withdrawn from antipsychotic medication for a 3-week period. The two scans were subtracted from one another, using a within subjects design, and the areas of difference were identified using the Montreal method. Subjects treated with antipsychotic medication had significantly higher rCBF in the left basal ganglia and left fusiform gyrus compared with the “off-medication” condition. Significantly higher relative rCBF in the anterior cingulate, left dorsolateral and inferior frontal cortex, and left and right cerebellum was observed when off antipsychotic medication. Upregulation of dopamine D2 receptors may lead to a regional increase of blood flow and metabolism in the basal ganglia, which may explain recently reported anatomical enlargement in these regions.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1016/S0893-133X(97)00042-0</identifier><identifier>PMID: 9326747</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>Cham: Elsevier Inc</publisher><subject>[15O]H2O PET ; Adolescent ; Adult ; Antipsychotic Agents - pharmacology ; Antipsychotics ; Behavioral Sciences ; Biological and medical sciences ; Biological Psychology ; Brain - pathology ; Cerebrovascular Circulation - drug effects ; Female ; Humans ; Image Processing, Computer-Assisted ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Middle Aged ; Neuropharmacology ; Neurosciences ; original-article ; Pharmacology. 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Psychiatry ; Psychopharmacology ; Regional cerebral blood flow ; Schizophrenia ; Schizophrenia - pathology ; Schizophrenia - physiopathology ; Tomography, Emission-Computed</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 1997-10, Vol.17 (4), p.230-240</ispartof><rights>1997 American College of Neuropsychopharmacology</rights><rights>American College of Neuropsychopharmacology 1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-dfd699cbcfb572b819b9399de771a54060156b65486fe002d97e1b55b120ef473</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1016/S0893-133X(97)00042-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1016/S0893-133X(97)00042-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2856071$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9326747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, Del D</creatorcontrib><creatorcontrib>Andreasen, Nancy C.</creatorcontrib><creatorcontrib>O'Leary, Daniel S.</creatorcontrib><creatorcontrib>Rezai, Karim</creatorcontrib><creatorcontrib>Leonard Watkins, G.</creatorcontrib><creatorcontrib>Boles Ponto, Laura L.</creatorcontrib><creatorcontrib>Hichwa, Richard D.</creatorcontrib><title>Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacol</addtitle><addtitle>Neuropsychopharmacology</addtitle><description>Positron Emission Tomography (PET) imaging of regional cerebral blood flow (rCBF) provides an in vivo method for studying brain function. We used [15O]H2O PET to assess the effect of antipsychotic medications on rCBF in 17 subjects with schizophrenia. Each subject was scanned while receiving antipsychotic medication, and after having been withdrawn from antipsychotic medication for a 3-week period. The two scans were subtracted from one another, using a within subjects design, and the areas of difference were identified using the Montreal method. Subjects treated with antipsychotic medication had significantly higher rCBF in the left basal ganglia and left fusiform gyrus compared with the “off-medication” condition. Significantly higher relative rCBF in the anterior cingulate, left dorsolateral and inferior frontal cortex, and left and right cerebellum was observed when off antipsychotic medication. Upregulation of dopamine D2 receptors may lead to a regional increase of blood flow and metabolism in the basal ganglia, which may explain recently reported anatomical enlargement in these regions.</description><subject>[15O]H2O PET</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Antipsychotics</subject><subject>Behavioral Sciences</subject><subject>Biological and medical sciences</subject><subject>Biological Psychology</subject><subject>Brain - pathology</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Female</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Neurosciences</subject><subject>original-article</subject><subject>Pharmacology. Drug treatments</subject><subject>Pharmacotherapy</subject><subject>Psychiatry</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Regional cerebral blood flow</subject><subject>Schizophrenia</subject><subject>Schizophrenia - pathology</subject><subject>Schizophrenia - physiopathology</subject><subject>Tomography, Emission-Computed</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKtvCT6jkA0JwCNj5sOMTQlUpSJU4AFJvlj_Gu66SOHgSqv33uN3VXnuypXmfmfFjQi45-8QZF59_sV41FW-auw9KfmSMtXXFXpANly2rRNPevSSbU-Q1OUe8Z4x3UvRn5Ew1tZCt3BB3HQK4haZAzbTEGfdul5bokKaJZtjGNJmBOshgc7nYISVPw5Ae6AgG1wyePsRlR-eEccmFgTEiFoouaUzbbObd_g15FcyA8PZ4XpA_365_X32vbn_e_Lj6elu5tm-WygcvlHLWBdvJ2vZcWdUo5UFKbrqWibK9sKJrexGAsdorCdx2neU1g9DK5oK8P_Sdc_q7Ai667OJgGMwEaUUty6uZ7FQJdoegywkxQ9BzjqPJe82ZfpSrn-TqR3NaSf0kV7PCXR4HrHYEf6KONkv93bFu0JkhZDO5iKdY3XeCSV5i4hDDUpm2kPV9WnPxjM_O_3IAoVj8FwuILsLkwMdcPlH7FJ_p8B-ia6jI</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Miller, Del D</creator><creator>Andreasen, Nancy C.</creator><creator>O'Leary, Daniel S.</creator><creator>Rezai, Karim</creator><creator>Leonard Watkins, G.</creator><creator>Boles Ponto, Laura L.</creator><creator>Hichwa, Richard D.</creator><general>Elsevier Inc</general><general>Springer International Publishing</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19971001</creationdate><title>Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography</title><author>Miller, Del D ; Andreasen, Nancy C. ; O'Leary, Daniel S. ; Rezai, Karim ; Leonard Watkins, G. ; Boles Ponto, Laura L. ; Hichwa, Richard D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-dfd699cbcfb572b819b9399de771a54060156b65486fe002d97e1b55b120ef473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>[15O]H2O PET</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Antipsychotic Agents - pharmacology</topic><topic>Antipsychotics</topic><topic>Behavioral Sciences</topic><topic>Biological and medical sciences</topic><topic>Biological Psychology</topic><topic>Brain - pathology</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Female</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Neurosciences</topic><topic>original-article</topic><topic>Pharmacology. Drug treatments</topic><topic>Pharmacotherapy</topic><topic>Psychiatry</topic><topic>Psycholeptics: tranquillizer, neuroleptic</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Regional cerebral blood flow</topic><topic>Schizophrenia</topic><topic>Schizophrenia - pathology</topic><topic>Schizophrenia - physiopathology</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, Del D</creatorcontrib><creatorcontrib>Andreasen, Nancy C.</creatorcontrib><creatorcontrib>O'Leary, Daniel S.</creatorcontrib><creatorcontrib>Rezai, Karim</creatorcontrib><creatorcontrib>Leonard Watkins, G.</creatorcontrib><creatorcontrib>Boles Ponto, Laura L.</creatorcontrib><creatorcontrib>Hichwa, Richard D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, Del D</au><au>Andreasen, Nancy C.</au><au>O'Leary, Daniel S.</au><au>Rezai, Karim</au><au>Leonard Watkins, G.</au><au>Boles Ponto, Laura L.</au><au>Hichwa, Richard D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><stitle>Neuropsychopharmacol</stitle><addtitle>Neuropsychopharmacology</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>17</volume><issue>4</issue><spage>230</spage><epage>240</epage><pages>230-240</pages><issn>0893-133X</issn><eissn>1740-634X</eissn><coden>NEROEW</coden><abstract>Positron Emission Tomography (PET) imaging of regional cerebral blood flow (rCBF) provides an in vivo method for studying brain function. We used [15O]H2O PET to assess the effect of antipsychotic medications on rCBF in 17 subjects with schizophrenia. Each subject was scanned while receiving antipsychotic medication, and after having been withdrawn from antipsychotic medication for a 3-week period. The two scans were subtracted from one another, using a within subjects design, and the areas of difference were identified using the Montreal method. Subjects treated with antipsychotic medication had significantly higher rCBF in the left basal ganglia and left fusiform gyrus compared with the “off-medication” condition. Significantly higher relative rCBF in the anterior cingulate, left dorsolateral and inferior frontal cortex, and left and right cerebellum was observed when off antipsychotic medication. 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| subjects | [15O]H2O PET Adolescent Adult Antipsychotic Agents - pharmacology Antipsychotics Behavioral Sciences Biological and medical sciences Biological Psychology Brain - pathology Cerebrovascular Circulation - drug effects Female Humans Image Processing, Computer-Assisted Male Medical sciences Medicine Medicine & Public Health Middle Aged Neuropharmacology Neurosciences original-article Pharmacology. Drug treatments Pharmacotherapy Psychiatry Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Regional cerebral blood flow Schizophrenia Schizophrenia - pathology Schizophrenia - physiopathology Tomography, Emission-Computed |
| title | Effect of antipsychotics on regional cerebral blood flow measured with positron emission tomography |
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