The CD40-ligand stimulates T-lymphocytes via the neutral sphingomyelinase : A novel function of the CD40-ligand as signalling molecule
Recent results suggest an activation of T-lymphocytes via the CD40L implying a dual function of this ligand involved in the activation of both B- and T-lymphocytes [1–4]. Here, we provide evidence that activation of T-lymphocytes via CD40L results in activation of a neutral but not an acidic sphingo...
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| Veröffentlicht in: | FEBS letters 1997-09, Vol.414 (2), p.444-448 |
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| creator | Koppenhoefer, U. Brenner, B. Lang, F. Gulbins, E. |
| description | Recent results suggest an activation of T-lymphocytes via the CD40L implying a dual function of this ligand involved in the activation of both B- and T-lymphocytes [1–4]. Here, we provide evidence that activation of T-lymphocytes via CD40L results in activation of a neutral but not an acidic sphingomyelinase correlating with a consumption of sphingomyelin and a release of ceramide. Activation of the neutral sphingomyelinase by the CD40L seems to involve a novel signalling cascade since it is independent of CD40L induced protein kinase activation or association of the neutral sphingomyelinase with the CD40L. |
| doi_str_mv | 10.1016/S0014-5793(97)01035-1 |
| format | Article |
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Here, we provide evidence that activation of T-lymphocytes via CD40L results in activation of a neutral but not an acidic sphingomyelinase correlating with a consumption of sphingomyelin and a release of ceramide. 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All rights reserved.</rights><rights>FEBS Letters 414 (1997) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5361-6e6e4df7396e5c13a1d5b6bda42d6b39997fc42dc35d939331b6e37b9f61a8623</citedby><cites>FETCH-LOGICAL-c5361-6e6e4df7396e5c13a1d5b6bda42d6b39997fc42dc35d939331b6e37b9f61a8623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0014-5793%2897%2901035-1$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014579397010351$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,3536,27903,27904,45553,45554,46387,46811,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9315737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koppenhoefer, U.</creatorcontrib><creatorcontrib>Brenner, B.</creatorcontrib><creatorcontrib>Lang, F.</creatorcontrib><creatorcontrib>Gulbins, E.</creatorcontrib><title>The CD40-ligand stimulates T-lymphocytes via the neutral sphingomyelinase : A novel function of the CD40-ligand as signalling molecule</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Recent results suggest an activation of T-lymphocytes via the CD40L implying a dual function of this ligand involved in the activation of both B- and T-lymphocytes [1–4]. 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Activation of the neutral sphingomyelinase by the CD40L seems to involve a novel signalling cascade since it is independent of CD40L induced protein kinase activation or association of the neutral sphingomyelinase with the CD40L.</description><subject>Animals</subject><subject>CD40 Antigens - physiology</subject><subject>CD40 Ligand</subject><subject>Cell Line</subject><subject>Ceramides - metabolism</subject><subject>Enzyme Activation</subject><subject>Kinetics</subject><subject>Membrane Glycoproteins - pharmacology</subject><subject>Mice</subject><subject>Neutral sphingomyelinase</subject><subject>Protein Kinases - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - physiology</subject><subject>Sphingomyelin Phosphodiesterase - metabolism</subject><subject>Sphingomyelins - metabolism</subject><subject>Substrate Specificity</subject><subject>T lymphocyte</subject><subject>T-Lymphocytes - enzymology</subject><subject>T-Lymphocytes - immunology</subject><subject>Tumor Cells, Cultured</subject><subject>Tyrosine kinase</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdFuFCEUhonR1LX6CE24MvViFJYBFm9M3bbWpIkXrteEYc7sYhhYh5k18wI-d5nZTeOV9YLA4Xz_fwg_QheUvKeEig_fCaFlwaVil0q-I5QwXtBnaEFXkhWsFKvnaPGIvESvUvpJcr2i6gydKUa5ZHKB_mx2gNfXJSm825pQ49S7dvCmh4Q3hR_b_S7acaoOzuA-wwGGvjMep_3OhW1sR_AumAT4I77CIR7A42YItncx4NjMkr_9TcLJbYPxWbXFbfRgBw-v0YvG-ARvTvs5-nF7s1nfFfffvnxdX90XljNBCwECyrqRTAngljJDa16JqjblshYVU0rJxuazZbxWTDFGKwFMVqoR1KzEkp2jt0fffRd_DZB63bpkwXsTIA5J569aEsmeBqlgiueVwct_g6UoOVmWJckoP6K2iyl10Oh951rTjZoSPWWq50z1FJhWUs-Zapp1F6cRQ9VC_ag6hZj7d8f-b-dh_D9TfXvzeTl3poaS8_U06tPRCnIIBwedTtZBsFC7Dmyv6-ieeOwDq8DEew</recordid><startdate>19970908</startdate><enddate>19970908</enddate><creator>Koppenhoefer, U.</creator><creator>Brenner, B.</creator><creator>Lang, F.</creator><creator>Gulbins, E.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19970908</creationdate><title>The CD40-ligand stimulates T-lymphocytes via the neutral sphingomyelinase : A novel function of the CD40-ligand as signalling molecule</title><author>Koppenhoefer, U. ; 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| ispartof | FEBS letters, 1997-09, Vol.414 (2), p.444-448 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | Animals CD40 Antigens - physiology CD40 Ligand Cell Line Ceramides - metabolism Enzyme Activation Kinetics Membrane Glycoproteins - pharmacology Mice Neutral sphingomyelinase Protein Kinases - metabolism Signal Transduction - drug effects Signal Transduction - physiology Sphingomyelin Phosphodiesterase - metabolism Sphingomyelins - metabolism Substrate Specificity T lymphocyte T-Lymphocytes - enzymology T-Lymphocytes - immunology Tumor Cells, Cultured Tyrosine kinase |
| title | The CD40-ligand stimulates T-lymphocytes via the neutral sphingomyelinase : A novel function of the CD40-ligand as signalling molecule |
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