Expression of the MDR1 gene product P‐glycoprotein in childhood neuroblastoma

BACKGROUND In cancer treated with chemotherapy, multidrug resistance is characterized by increased genetic expression of P‐glycoprotein (P‐gp), which acts as an ATP‐dependent drug‐efflux pump. However, the clinical significance of the expression of the multidrug resistance gene (MDR1) product P‐gp i...

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Veröffentlicht in:	Cancer 1997-10, Vol.80 (7), p.1250-1257
Hauptverfasser:	Dhooge, Catharina R. M., Moerloose, Barbara M. J. De, Benoit, Yves C. M., Roy, Nadine Van, Philippé, Jan, Laureys, Geneviève G. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use ATP Binding Cassette Transporter, Subfamily B, Member 1 - analysis ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics Biological and medical sciences Bone Marrow Neoplasms - secondary Chemotherapy Child Child, Preschool Combined Modality Therapy Disease-Free Survival Drug Resistance, Multiple - genetics Gene Expression Regulation, Neoplastic - genetics Genes, MDR Humans Infant MDR1 Medical sciences metastasis multidrug resistance neuroblastoma Neuroblastoma - chemistry Neuroblastoma - genetics Neuroblastoma - pathology Neuroblastoma - therapy Pharmacology. Drug treatments Ploidies Prognosis prognostic factors P‐glycoprotein P‐gp Treatment Outcome
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