Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units

We previously showed that a peptide (PR1) derived from the primary granule enzyme proteinase 3 induced peptide specific cytotoxic T lymphocytes (CTL) in a normal HLA-A2.1+ individual. These CTL showed HLA-restricted cytotoxicity to myeloid leukemias (which overexpress proteinase 3). To further inves...

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Veröffentlicht in:	Blood 1997-10, Vol.90 (7), p.2529-2534
Hauptverfasser:	MOLLDREM, J. J, CLAVE, E, JIANG, Y. Z, MAVROUDIS, D, RAPTIS, A, HENSEL, N, AGARWALA, V, BARRETT, A. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bone Marrow - pathology Cells, Cultured Cytotoxicity, Immunologic Exons - genetics Hemopathies HLA-A2 Antigen - immunology Humans Immunotherapy, Adoptive Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Medical sciences Myeloblastin Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - immunology Neoplastic Stem Cells - enzymology Neoplastic Stem Cells - immunology Peptide Fragments - genetics Peptide Fragments - immunology Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Serine Endopeptidases - chemistry Serine Endopeptidases - genetics Serine Endopeptidases - immunology T-Lymphocytes, Cytotoxic - immunology Tumor Cells, Cultured Tumor Stem Cell Assay
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