Immunity to diphtheria in a sample of adult population from central Italy
A sample of 643 healthy subjects from central Italy aged 20 to 80, were screened for diphtheria antitoxin. Serum diphtheria antitoxin was assayed by a new passive haemagglutination technique using turkey red blood cells sensitized with diphtheria toxoid, after having performed a correlation study be...
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| Veröffentlicht in: | Vaccine 1989-10, Vol.7 (5), p.417-420 |
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| container_title | Vaccine |
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| creator | CELLESI, C ZANCHI, A MICHELANGELI, C GIOVANNONI, F SANSONI, A ROSSOLINI, G. M |
| description | A sample of 643 healthy subjects from central Italy aged 20 to 80, were screened for diphtheria antitoxin. Serum diphtheria antitoxin was assayed by a new passive haemagglutination technique using turkey red blood cells sensitized with diphtheria toxoid, after having performed a correlation study between this technique and the reference in vivo neutralization test. Of the studied population 26.7% showed a lack of serum antitoxin titres considered to be protective. The rate of susceptible subjects increased with age, showing the highest value (38.9%) in the sixth decade of age. Males proved less protected than females; 53.2% of the male population aged 50-59 were lacking a protective anti-diphtheria immunity. On the basis of present results, a periodical revaccination of the entire adult population with reduced doses of diphtheria toxoid would be advisable. |
| doi_str_mv | 10.1016/0264-410x(89)90155-2 |
| format | Article |
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M</creatorcontrib><title>Immunity to diphtheria in a sample of adult population from central Italy</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>A sample of 643 healthy subjects from central Italy aged 20 to 80, were screened for diphtheria antitoxin. Serum diphtheria antitoxin was assayed by a new passive haemagglutination technique using turkey red blood cells sensitized with diphtheria toxoid, after having performed a correlation study between this technique and the reference in vivo neutralization test. Of the studied population 26.7% showed a lack of serum antitoxin titres considered to be protective. The rate of susceptible subjects increased with age, showing the highest value (38.9%) in the sixth decade of age. Males proved less protected than females; 53.2% of the male population aged 50-59 were lacking a protective anti-diphtheria immunity. On the basis of present results, a periodical revaccination of the entire adult population with reduced doses of diphtheria toxoid would be advisable.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Diphtheria - epidemiology</subject><subject>Diphtheria - immunology</subject><subject>Diphtheria Antitoxin - analysis</subject><subject>Female</subject><subject>Hemagglutination Tests</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Neutralization Tests</subject><subject>Predictive Value of Tests</subject><subject>Prevalence</subject><subject>Seroepidemiologic Studies</subject><subject>Sex Factors</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLxDAUBeAgyjiO_gOFLER0Uc2jaZKlDD4KA24U3JXbJmEi6cMmBeffO2B1K2dxF-fjLg5C55TcUkKLO8KKPMsp-bpW-kYTKkTGDtCSKskzJqg6RMtf8n6MTmL8IIQITvUCLZiiQku5RGXZtlPn0w6nHhs_bNPWjh6w7zDgCO0QLO4dBjOFhId-mAIk33fYjX2LG9ulEQIuE4TdKTpyEKI9m-8KvT0-vK6fs83LU7m-32QfTPOUWUFqKimRtHCq4c45KHKuidESdC1y7YTOJXOSSDCNUYZpxQjUpgBNjbN8ha5-_g5j_znZmKrWx8aGAJ3tp1hJzanSef4vpILnmnC-hxcznOrWmmoYfQvjrppH2veXcw-xgeBG6Bof_5jk-xQF_wYEdHZo</recordid><startdate>19891001</startdate><enddate>19891001</enddate><creator>CELLESI, C</creator><creator>ZANCHI, A</creator><creator>MICHELANGELI, C</creator><creator>GIOVANNONI, F</creator><creator>SANSONI, A</creator><creator>ROSSOLINI, G. 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M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j293t-e50b1710716f8c3fffa64390d97a9b549f59472f707adcd8d29820abd6a91dfe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Diphtheria - epidemiology</topic><topic>Diphtheria - immunology</topic><topic>Diphtheria Antitoxin - analysis</topic><topic>Female</topic><topic>Hemagglutination Tests</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Neutralization Tests</topic><topic>Predictive Value of Tests</topic><topic>Prevalence</topic><topic>Seroepidemiologic Studies</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CELLESI, C</creatorcontrib><creatorcontrib>ZANCHI, A</creatorcontrib><creatorcontrib>MICHELANGELI, C</creatorcontrib><creatorcontrib>GIOVANNONI, F</creatorcontrib><creatorcontrib>SANSONI, A</creatorcontrib><creatorcontrib>ROSSOLINI, G. 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The rate of susceptible subjects increased with age, showing the highest value (38.9%) in the sixth decade of age. Males proved less protected than females; 53.2% of the male population aged 50-59 were lacking a protective anti-diphtheria immunity. On the basis of present results, a periodical revaccination of the entire adult population with reduced doses of diphtheria toxoid would be advisable.</abstract><cop>Oxford</cop><pub>Elsevier</pub><pmid>2815977</pmid><doi>10.1016/0264-410x(89)90155-2</doi><tpages>4</tpages></addata></record> |
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| ispartof | Vaccine, 1989-10, Vol.7 (5), p.417-420 |
| issn | 0264-410X 1873-2518 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Age Factors Aged Aged, 80 and over Bacterial diseases Biological and medical sciences Diphtheria - epidemiology Diphtheria - immunology Diphtheria Antitoxin - analysis Female Hemagglutination Tests Human bacterial diseases Humans Infectious diseases Italy - epidemiology Male Medical sciences Middle Aged Miscellaneous Neutralization Tests Predictive Value of Tests Prevalence Seroepidemiologic Studies Sex Factors |
| title | Immunity to diphtheria in a sample of adult population from central Italy |
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