Construction and evaluation of a double mutant of Shigella flexneri as a candidate for oral vaccination against shigellosis

Based on studies on the genetic and molecular basis of Shigella flexneri invasive properties, we have constructed and evaluated a double mutant of S. flexneri serotype 5 for utilization as a live attenuated oral vaccine against shigellosis. The first mutation, icsA, blocks intracellular spread of ba...

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