Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP-27, but not PACAP-38) degradation by the neutral endopeptidase EC 3.4.24.11

VIP (vasoactive intestinal polypeptide) and PACAP (pituitary adenylate cyclase-activating polypeptide), which are potent relaxing agents in the airways, were submitted to in vitro degradation by the neutral endopeptidase EC 3.4.24-11 (NEP), one of the most active peptidase in the lung, to test their...

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Veröffentlicht in:	Biochemical pharmacology 1997-08, Vol.54 (4), p.509-515
Hauptverfasser:	Gourlet, Philippe, Vandermeers, André, Robberecht, Patrick, Deschodt-lanckman, Monique
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences degradation Humans Kidney - enzymology Medical sciences metabolite activity Molecular Sequence Data Neprilysin - physiology Neuropeptides - metabolism Neuropharmacology Neurotransmitters. Neurotransmission. Receptors neutral endopeptidase PACAP Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Pituitary Adenylate Cyclase-Activating Polypeptide Vasoactive Intestinal Peptide - metabolism VIP
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