Methoctramine moderately improves memory but pirenzepine disrupts performance in delayed non-matching to position test
The present study was designed to investigate the effect of i.c.v. administration of various muscarinic receptor antagonists in rats on memory performance in delayed non-matching to position test. The drugs chosen were the non-selective antagonist scopolamine (3 and 10 μg), the muscarinic M 1 recept...
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| Veröffentlicht in: | European journal of pharmacology 1997-08, Vol.333 (2), p.129-134 |
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| creator | Aura, Juhana Sirviö, Jouni Riekkinen, Paavo |
| description | The present study was designed to investigate the effect of i.c.v. administration of various muscarinic receptor antagonists in rats on memory performance in delayed non-matching to position test. The drugs chosen were the non-selective antagonist scopolamine (3 and 10
μg), the muscarinic M
1 receptor-selective antagonist pirenzepine (10 and 30
μg) and the muscarinic M
2 receptor-selective antagonist methoctramine (2, 5 and 20
μg). Scopolamine delay-independently decreased % correct choices and reduced motor activity. Pirenzepine also delay-independently decreased % correct choices. In contrast, methoctramine 2
μg, but not at 5 or 20
μg, improved slightly, but significantly, % correct performance delay-dependently. The present data suggests that the decrease in activation of inhibitory muscarinic M
2 autoreceptors induced by methoctramine produces a specific improvement of short-term memory at long forgetting delays. |
| doi_str_mv | 10.1016/S0014-2999(97)01134-5 |
| format | Article |
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μg), the muscarinic M
1 receptor-selective antagonist pirenzepine (10 and 30
μg) and the muscarinic M
2 receptor-selective antagonist methoctramine (2, 5 and 20
μg). Scopolamine delay-independently decreased % correct choices and reduced motor activity. Pirenzepine also delay-independently decreased % correct choices. In contrast, methoctramine 2
μg, but not at 5 or 20
μg, improved slightly, but significantly, % correct performance delay-dependently. The present data suggests that the decrease in activation of inhibitory muscarinic M
2 autoreceptors induced by methoctramine produces a specific improvement of short-term memory at long forgetting delays.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/S0014-2999(97)01134-5</identifier><identifier>PMID: 9314025</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Alzheimer's disease ; Animal ; Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - physiology ; correct choice ; Delay-dependent and -independent ; Diamines - pharmacology ; Fundamental and applied biological sciences. Psychology ; Injections, Intraventricular ; Learning. Memory ; Male ; Memory ; Memory - drug effects ; Methoctramine ; Motor Activity - drug effects ; Muscarinic Antagonists - pharmacology ; Muscarinic M 1 receptor ; Muscarinic M 2 receptor ; Parasympatholytics - pharmacology ; Pirenzepine ; Pirenzepine - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Wistar ; Receptor, Muscarinic M1 ; Receptor, Muscarinic M2 ; Receptors, Muscarinic - drug effects ; Scopolamine ; Scopolamine - pharmacology</subject><ispartof>European journal of pharmacology, 1997-08, Vol.333 (2), p.129-134</ispartof><rights>1997 Elsevier Science B.V.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-5acd3cadc7188aea68857676cb19cc5dcb28c4f6635ab3ce10f96779b3cbb4543</citedby><cites>FETCH-LOGICAL-c420t-5acd3cadc7188aea68857676cb19cc5dcb28c4f6635ab3ce10f96779b3cbb4543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0014-2999(97)01134-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2805299$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9314025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aura, Juhana</creatorcontrib><creatorcontrib>Sirviö, Jouni</creatorcontrib><creatorcontrib>Riekkinen, Paavo</creatorcontrib><title>Methoctramine moderately improves memory but pirenzepine disrupts performance in delayed non-matching to position test</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The present study was designed to investigate the effect of i.c.v. administration of various muscarinic receptor antagonists in rats on memory performance in delayed non-matching to position test. The drugs chosen were the non-selective antagonist scopolamine (3 and 10
μg), the muscarinic M
1 receptor-selective antagonist pirenzepine (10 and 30
μg) and the muscarinic M
2 receptor-selective antagonist methoctramine (2, 5 and 20
μg). Scopolamine delay-independently decreased % correct choices and reduced motor activity. Pirenzepine also delay-independently decreased % correct choices. In contrast, methoctramine 2
μg, but not at 5 or 20
μg, improved slightly, but significantly, % correct performance delay-dependently. The present data suggests that the decrease in activation of inhibitory muscarinic M
2 autoreceptors induced by methoctramine produces a specific improvement of short-term memory at long forgetting delays.</description><subject>Alzheimer's disease</subject><subject>Animal</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>correct choice</subject><subject>Delay-dependent and -independent</subject><subject>Diamines - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraventricular</subject><subject>Learning. Memory</subject><subject>Male</subject><subject>Memory</subject><subject>Memory - drug effects</subject><subject>Methoctramine</subject><subject>Motor Activity - drug effects</subject><subject>Muscarinic Antagonists - pharmacology</subject><subject>Muscarinic M 1 receptor</subject><subject>Muscarinic M 2 receptor</subject><subject>Parasympatholytics - pharmacology</subject><subject>Pirenzepine</subject><subject>Pirenzepine - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptor, Muscarinic M1</subject><subject>Receptor, Muscarinic M2</subject><subject>Receptors, Muscarinic - drug effects</subject><subject>Scopolamine</subject><subject>Scopolamine - pharmacology</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFCEUx4nR1G3rR2jCwRh7GIWZAYaTMU2rJjUetGfCwBuLGWAEZpP108t2N3vtCZL3e-_B74_QFSUfKKH8409CaN-0Usr3UlwTSru-YS_Qhg5CNkTQ9iXanJDX6DznP4QQJlt2hs5kR3vSsg3afofyGE1J2rsA2EcLSReYd9j5JcUtZOzBx7TD41rw4hKEf7DsUetyWpeS8QJpisnrYAC7gC3MegcWhxgar4t5dOE3LhEvMbviYsAFcrlEryY9Z3hzPC_Qw93tr5uvzf2PL99uPt83pm9JaZg2tjPaGkGHQYPmw8AEF9yMVBrDrBnbwfQT5x3TY2eAkklyIWS9j2PP-u4CvTvMrX_5u9bFyrtsYJ51gLhmJaoIzjh9FqS8p9VjV0F2AE2KOSeY1JKc12mnKFH7YNRTMGpvXUmhnoJRrPZdHResowd76jomUetvj3WdjZ6nVH26fMLagbA6smKfDhhUa1sHSWXjoKq3NRpTlI3umYf8B2i1rZ4</recordid><startdate>19970827</startdate><enddate>19970827</enddate><creator>Aura, Juhana</creator><creator>Sirviö, Jouni</creator><creator>Riekkinen, Paavo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970827</creationdate><title>Methoctramine moderately improves memory but pirenzepine disrupts performance in delayed non-matching to position test</title><author>Aura, Juhana ; Sirviö, Jouni ; Riekkinen, Paavo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-5acd3cadc7188aea68857676cb19cc5dcb28c4f6635ab3ce10f96779b3cbb4543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Alzheimer's disease</topic><topic>Animal</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - physiology</topic><topic>correct choice</topic><topic>Delay-dependent and -independent</topic><topic>Diamines - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraventricular</topic><topic>Learning. Memory</topic><topic>Male</topic><topic>Memory</topic><topic>Memory - drug effects</topic><topic>Methoctramine</topic><topic>Motor Activity - drug effects</topic><topic>Muscarinic Antagonists - pharmacology</topic><topic>Muscarinic M 1 receptor</topic><topic>Muscarinic M 2 receptor</topic><topic>Parasympatholytics - pharmacology</topic><topic>Pirenzepine</topic><topic>Pirenzepine - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptor, Muscarinic M1</topic><topic>Receptor, Muscarinic M2</topic><topic>Receptors, Muscarinic - drug effects</topic><topic>Scopolamine</topic><topic>Scopolamine - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aura, Juhana</creatorcontrib><creatorcontrib>Sirviö, Jouni</creatorcontrib><creatorcontrib>Riekkinen, Paavo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aura, Juhana</au><au>Sirviö, Jouni</au><au>Riekkinen, Paavo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methoctramine moderately improves memory but pirenzepine disrupts performance in delayed non-matching to position test</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1997-08-27</date><risdate>1997</risdate><volume>333</volume><issue>2</issue><spage>129</spage><epage>134</epage><pages>129-134</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The present study was designed to investigate the effect of i.c.v. administration of various muscarinic receptor antagonists in rats on memory performance in delayed non-matching to position test. The drugs chosen were the non-selective antagonist scopolamine (3 and 10
μg), the muscarinic M
1 receptor-selective antagonist pirenzepine (10 and 30
μg) and the muscarinic M
2 receptor-selective antagonist methoctramine (2, 5 and 20
μg). Scopolamine delay-independently decreased % correct choices and reduced motor activity. Pirenzepine also delay-independently decreased % correct choices. In contrast, methoctramine 2
μg, but not at 5 or 20
μg, improved slightly, but significantly, % correct performance delay-dependently. The present data suggests that the decrease in activation of inhibitory muscarinic M
2 autoreceptors induced by methoctramine produces a specific improvement of short-term memory at long forgetting delays.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9314025</pmid><doi>10.1016/S0014-2999(97)01134-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | European journal of pharmacology, 1997-08, Vol.333 (2), p.129-134 |
| issn | 0014-2999 1879-0712 |
| language | eng |
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| subjects | Alzheimer's disease Animal Animals Biological and medical sciences Brain - drug effects Brain - physiology correct choice Delay-dependent and -independent Diamines - pharmacology Fundamental and applied biological sciences. Psychology Injections, Intraventricular Learning. Memory Male Memory Memory - drug effects Methoctramine Motor Activity - drug effects Muscarinic Antagonists - pharmacology Muscarinic M 1 receptor Muscarinic M 2 receptor Parasympatholytics - pharmacology Pirenzepine Pirenzepine - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Receptor, Muscarinic M1 Receptor, Muscarinic M2 Receptors, Muscarinic - drug effects Scopolamine Scopolamine - pharmacology |
| title | Methoctramine moderately improves memory but pirenzepine disrupts performance in delayed non-matching to position test |
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