Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats
Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of the aqueous and 50% ethanolic extracts of Caesalpinia bonducella Fleming (Leguminosae) seeds were studied in normal and streptozotocin (SZ)-diabetic rats. In normal rats, both the extracts exhibited hypoglycaemic activity as early as...
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| Veröffentlicht in: | Journal of ethnopharmacology 1997-09, Vol.58 (1), p.39-44 |
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| creator | Sharma, S.R. Dwivedi, S.K. Swarup, D. |
| description | Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of the aqueous and 50% ethanolic extracts of
Caesalpinia bonducella Fleming (Leguminosae) seeds were studied in normal and streptozotocin (SZ)-diabetic rats. In normal rats, both the extracts exhibited hypoglycaemic activity as early as 4 h after administration at a lower dose of 100 mg/kg. The hypoglycaemia produced by the aqueous extract was of prolonged duration as compared to ethanolic extract. In diabetic rats, both the extracts produced significant (
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| doi_str_mv | 10.1016/S0378-8741(97)00079-2 |
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Caesalpinia bonducella Fleming (Leguminosae) seeds were studied in normal and streptozotocin (SZ)-diabetic rats. In normal rats, both the extracts exhibited hypoglycaemic activity as early as 4 h after administration at a lower dose of 100 mg/kg. The hypoglycaemia produced by the aqueous extract was of prolonged duration as compared to ethanolic extract. In diabetic rats, both the extracts produced significant (
P<0.01) antihyperglycaemic effect from day 5 onwards. Aqueous extract also exhibited antihypercholesterolemic and antihypertriglyceridemic effects in SZ-diabetic rats. These results suggest that
C. bonducella seeds possess an antidiabetic principle and can be useful for treatment of diabetes. Further studies are warranted to fractionate the active principle and to find out its exact mechanism of action.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/S0378-8741(97)00079-2</identifier><identifier>PMID: 9324003</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Administration, Oral ; Animals ; Antihyperglycaemic effect ; Aqueous extract ; Biological and medical sciences ; Blood Glucose - analysis ; Caesalpinia bonduc ; Caesalpinia bonducella seeds ; Cholesterol - blood ; Diabetes Mellitus, Experimental - drug therapy ; Ethanol - chemistry ; Ethanolic extract ; Female ; General pharmacology ; Hypoglycaemic effect ; Hypoglycemic Agents - pharmacology ; Hypolipidemic Agents - pharmacology ; Hypolipidemic effect ; India ; Male ; Medical sciences ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - pharmacology ; Rats ; Rats, Wistar ; Seeds - chemistry ; Streptozotocin diabetic rats ; Triglycerides - blood ; Water - chemistry</subject><ispartof>Journal of ethnopharmacology, 1997-09, Vol.58 (1), p.39-44</ispartof><rights>1997 Elsevier Science Ireland Ltd</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-1c7d09ef9dec05ba383045b8db2c3ab23497901cdac57cba304e4749fca487823</citedby><cites>FETCH-LOGICAL-c479t-1c7d09ef9dec05ba383045b8db2c3ab23497901cdac57cba304e4749fca487823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874197000792$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2836561$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9324003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharma, S.R.</creatorcontrib><creatorcontrib>Dwivedi, S.K.</creatorcontrib><creatorcontrib>Swarup, D.</creatorcontrib><title>Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of the aqueous and 50% ethanolic extracts of
Caesalpinia bonducella Fleming (Leguminosae) seeds were studied in normal and streptozotocin (SZ)-diabetic rats. In normal rats, both the extracts exhibited hypoglycaemic activity as early as 4 h after administration at a lower dose of 100 mg/kg. The hypoglycaemia produced by the aqueous extract was of prolonged duration as compared to ethanolic extract. In diabetic rats, both the extracts produced significant (
P<0.01) antihyperglycaemic effect from day 5 onwards. Aqueous extract also exhibited antihypercholesterolemic and antihypertriglyceridemic effects in SZ-diabetic rats. These results suggest that
C. bonducella seeds possess an antidiabetic principle and can be useful for treatment of diabetes. Further studies are warranted to fractionate the active principle and to find out its exact mechanism of action.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Antihyperglycaemic effect</subject><subject>Aqueous extract</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Caesalpinia bonduc</subject><subject>Caesalpinia bonducella seeds</subject><subject>Cholesterol - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>Ethanol - chemistry</subject><subject>Ethanolic extract</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Hypoglycaemic effect</subject><subject>Hypoglycemic Agents - pharmacology</subject><subject>Hypolipidemic Agents - pharmacology</subject><subject>Hypolipidemic effect</subject><subject>India</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Seeds - chemistry</subject><subject>Streptozotocin diabetic rats</subject><subject>Triglycerides - blood</subject><subject>Water - chemistry</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF-L1DAUxYMo6zj6ERb7IKJgNf_aNE8ig7rCgg_rPofbm9s10mlr0lmYb286HebVp8A5v5tzOIxdC_5RcFF_uuPKNGVjtHhnzXvOubGlfMI2ojGyNJVRT9nmgjxnL1L6s0BC8yt2ZZXUnKsN626O0_jQHxFoH_BDAcMcfh8nihctS77I0tiHKfhVwTk8hjlQKsau2AEl6KcwBCjacfAHpL6HIhH5VIShiDCnl-xZB32iV-d3y-6_ff21uylvf37_sftyW6I2di4FGs8tddYT8qoF1Siuq7bxrUQFrVTaGssFesDKYPa5Jm207RB0Yxqptuzt-u8Ux78HSrPbh3TqM9B4SM5YJWrFRQarFcQ4phSpc1MMe4hHJ7hb9nWnfd0ynrPGnfZ1S8D1OeDQ7slfrs6DZv_N2YeE0HcRBgzpgslG1VW9xL9esQ5GBw8xI_d3MvfiMifWGduyzytBea7HQNElDDQg-RAJZ-fH8J-q_wB4BqIk</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Sharma, S.R.</creator><creator>Dwivedi, S.K.</creator><creator>Swarup, D.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats</title><author>Sharma, S.R. ; Dwivedi, S.K. ; Swarup, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-1c7d09ef9dec05ba383045b8db2c3ab23497901cdac57cba304e4749fca487823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Antihyperglycaemic effect</topic><topic>Aqueous extract</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Caesalpinia bonduc</topic><topic>Caesalpinia bonducella seeds</topic><topic>Cholesterol - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>Ethanol - chemistry</topic><topic>Ethanolic extract</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Hypoglycaemic effect</topic><topic>Hypoglycemic Agents - pharmacology</topic><topic>Hypolipidemic Agents - pharmacology</topic><topic>Hypolipidemic effect</topic><topic>India</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Seeds - chemistry</topic><topic>Streptozotocin diabetic rats</topic><topic>Triglycerides - blood</topic><topic>Water - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharma, S.R.</creatorcontrib><creatorcontrib>Dwivedi, S.K.</creatorcontrib><creatorcontrib>Swarup, D.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharma, S.R.</au><au>Dwivedi, S.K.</au><au>Swarup, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>58</volume><issue>1</issue><spage>39</spage><epage>44</epage><pages>39-44</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of the aqueous and 50% ethanolic extracts of
Caesalpinia bonducella Fleming (Leguminosae) seeds were studied in normal and streptozotocin (SZ)-diabetic rats. In normal rats, both the extracts exhibited hypoglycaemic activity as early as 4 h after administration at a lower dose of 100 mg/kg. The hypoglycaemia produced by the aqueous extract was of prolonged duration as compared to ethanolic extract. In diabetic rats, both the extracts produced significant (
P<0.01) antihyperglycaemic effect from day 5 onwards. Aqueous extract also exhibited antihypercholesterolemic and antihypertriglyceridemic effects in SZ-diabetic rats. These results suggest that
C. bonducella seeds possess an antidiabetic principle and can be useful for treatment of diabetes. Further studies are warranted to fractionate the active principle and to find out its exact mechanism of action.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9324003</pmid><doi>10.1016/S0378-8741(97)00079-2</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Oral Animals Antihyperglycaemic effect Aqueous extract Biological and medical sciences Blood Glucose - analysis Caesalpinia bonduc Caesalpinia bonducella seeds Cholesterol - blood Diabetes Mellitus, Experimental - drug therapy Ethanol - chemistry Ethanolic extract Female General pharmacology Hypoglycaemic effect Hypoglycemic Agents - pharmacology Hypolipidemic Agents - pharmacology Hypolipidemic effect India Male Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - pharmacology Rats Rats, Wistar Seeds - chemistry Streptozotocin diabetic rats Triglycerides - blood Water - chemistry |
| title | Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats |
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