Transbilayer Distribution of Cholesterol Is Modified in Brain Synaptic Plasma Membranes of Knockout Mice Deficient in the Low‐Density Lipoprotein Receptor, Apolipoprotein E, or Both Proteins

: Both apolipoprotein E (apoE) and the low‐density lipoprotein (LDL) receptor are present in brain; however, little is known regarding the function of these proteins in brain, in particular with respect to brain cholesterol. The role of apoE and the LDL receptor in modulating the transbilayer or asy...

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Veröffentlicht in:	Journal of neurochemistry 1997-10, Vol.69 (4), p.1661-1667
Hauptverfasser:	Igbavboa, Urule, Avdulov, Nicolai A., Chochina, Svetlana V., Wood, W. Gibson
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein E Apolipoproteins E - deficiency Apolipoproteins E - genetics Biochemistry and metabolism Biological and medical sciences Brain Brain - metabolism Central nervous system Cholesterol Cholesterol - metabolism Ergosterol - analogs & derivatives Ergosterol - metabolism Fluidity Fundamental and applied biological sciences. Psychology Low‐density lipoprotein receptor Membrane Fluidity - physiology Mice Mice, Inbred C57BL Mice, Knockout - genetics Mice, Knockout - metabolism Phospholipids - metabolism Receptors, LDL - deficiency Receptors, LDL - genetics Synaptic Membranes - metabolism Tissue Distribution Trinitrobenzenesulfonic Acid Vertebrates: nervous system and sense organs
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