Colchicine down-regulates lipopolysaccharide-induced granulocyte- macrophage colony-stimulating factor production in murine macrophages

Activation of macrophages by LPS and taxol results in production of IL-1, IL-6, TNF-alpha, and granulocyte-macrophage CSF (GM-CSF), which are involved in regulating hemopoiesis, inflammation, and immune responses. Microtubules are proposed as a target site for LPS interaction(s), based on similariti...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-10, Vol.159 (7), p.3531-3539
Hauptverfasser:	Rao, P, Falk, LA, Dougherty, SF, Sawada, T, Pluznik, DH
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Transport - drug effects Calcium-Calmodulin-Dependent Protein Kinases - drug effects Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Line Cell Nucleus - metabolism Colchicine - pharmacology Down-Regulation - drug effects Down-Regulation - immunology Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis Granulocyte-Macrophage Colony-Stimulating Factor - genetics Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mice Microtubules - drug effects Microtubules - immunology NF-kappa B - drug effects NF-kappa B - metabolism Paclitaxel - pharmacology Phosphorylation - drug effects Promoter Regions, Genetic - drug effects Promoter Regions, Genetic - immunology RNA, Messenger - biosynthesis RNA, Messenger - drug effects RNA, Messenger - immunology Time Factors Transcription, Genetic - drug effects Transcription, Genetic - immunology Tubulin - drug effects Tubulin - genetics Tyrosine - metabolism
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