Comparative analysis of isolated human bronchi contraction and biosynthesis of cysteinyl leukotrienes using a direct 5-lipoxygenase inhibitor

Quantitation of cysteinyl leukotriene production and smooth muscle contraction upon immunological challenge of isolated human bronchi was evaluated. Analysis of picomole amounts of leukotriene C 4, D 4, and E 4 was achieved using HPLC separation and enzyme immunoassay quantitative determination. The...

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Veröffentlicht in:	Biochemical pharmacology 1997-08, Vol.54 (4), p.437-442
Hauptverfasser:	Bolla, Manlio, Caruso, Paola, Giossi, Massimo, Folco, Giancarlo, Civelli, Maurizio, Sala, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	5-lipoxygenase inhibition Biological and medical sciences Bronchi - metabolism Bronchoconstriction - drug effects Cysteine - biosynthesis cysteinyl leukotrienes Dose-Response Relationship, Drug HPLC, enzyme immunoassay Humans Immunoglobulin E - immunology immunological challenge In Vitro Techniques isolated human bronchi Leukotrienes - biosynthesis Lipoxygenase Inhibitors - pharmacology Medical sciences Pharmacology. Drug treatments Respiratory system
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