Sequential expression and role of Hu RNA-binding proteins during neurogenesis
We have identified three avian (chicken) Hu/elav family RNA-binding protein genes. cHuD and cHuC are expressed specifically in neurons of both the central and peripheral nervous systems. Although cHuA is expressed in a wide variety of tissues, including neurogenic precursor cells, it is transiently...
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| Veröffentlicht in: | Development (Cambridge) 1997-09, Vol.124 (17), p.3449-3460 |
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| creator | Wakamatsu, Y Weston, J A |
| description | We have identified three avian (chicken) Hu/elav family RNA-binding protein genes. cHuD and cHuC are expressed specifically in neurons of both the central and peripheral nervous systems. Although cHuA is expressed in a wide variety of tissues, including neurogenic precursor cells, it is transiently down-regulated, and is then re-expressed in maturing neurons. Misexpression of cHuD in cultured neural crest cells results in a dramatic increase in the proportion of cells exhibiting neuronal morphology, molecular markers for neurons, and neurotrophin dependence. These data confirm that cHuD protein is involved in regulating neuronal differentiation. |
| doi_str_mv | 10.1242/dev.124.17.3449 |
| format | Article |
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Although cHuA is expressed in a wide variety of tissues, including neurogenic precursor cells, it is transiently down-regulated, and is then re-expressed in maturing neurons. Misexpression of cHuD in cultured neural crest cells results in a dramatic increase in the proportion of cells exhibiting neuronal morphology, molecular markers for neurons, and neurotrophin dependence. These data confirm that cHuD protein is involved in regulating neuronal differentiation.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.124.17.3449</identifier><identifier>PMID: 9310339</identifier><language>eng</language><publisher>England: The Company of Biologists Limited</publisher><subject>3T3 Cells ; Amino Acid Sequence ; Animals ; Apoptosis ; Cell Differentiation ; Cell Division ; Cells, Cultured ; Chick Embryo ; Coturnix ; ELAV Proteins ; Gene Expression Regulation, Developmental ; Genetic Markers ; Humans ; In Situ Hybridization ; Mice ; Molecular Sequence Data ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - metabolism ; Nervous System - cytology ; Nervous System - embryology ; Nervous System - metabolism ; Neural Crest - cytology ; Neural Crest - metabolism ; Neurons - cytology ; Neurons - metabolism ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; Sequence Homology, Amino Acid ; Species Specificity ; Transfection</subject><ispartof>Development (Cambridge), 1997-09, Vol.124 (17), p.3449-3460</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-c7247bd1c91db6227ea114be628886c4798792e88665ee52b38f004c6dfcd0a93</citedby><cites>FETCH-LOGICAL-c428t-c7247bd1c91db6227ea114be628886c4798792e88665ee52b38f004c6dfcd0a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3678,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9310339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wakamatsu, Y</creatorcontrib><creatorcontrib>Weston, J A</creatorcontrib><title>Sequential expression and role of Hu RNA-binding proteins during neurogenesis</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>We have identified three avian (chicken) Hu/elav family RNA-binding protein genes. cHuD and cHuC are expressed specifically in neurons of both the central and peripheral nervous systems. Although cHuA is expressed in a wide variety of tissues, including neurogenic precursor cells, it is transiently down-regulated, and is then re-expressed in maturing neurons. Misexpression of cHuD in cultured neural crest cells results in a dramatic increase in the proportion of cells exhibiting neuronal morphology, molecular markers for neurons, and neurotrophin dependence. These data confirm that cHuD protein is involved in regulating neuronal differentiation.</description><subject>3T3 Cells</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Cell Differentiation</subject><subject>Cell Division</subject><subject>Cells, Cultured</subject><subject>Chick Embryo</subject><subject>Coturnix</subject><subject>ELAV Proteins</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genetic Markers</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nervous System - cytology</subject><subject>Nervous System - embryology</subject><subject>Nervous System - metabolism</subject><subject>Neural Crest - cytology</subject><subject>Neural Crest - metabolism</subject><subject>Neurons - cytology</subject><subject>Neurons - metabolism</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA-Binding Proteins - genetics</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>Sequence Homology, Amino Acid</subject><subject>Species Specificity</subject><subject>Transfection</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUMtOwzAQtBAIyuPMCSknbile27XjI0K8pAISj7OVxJtilNrFTnj8PYlaIXHitLOa2dHsEHIMdApMsDOLHyOYgppyIfQWmYBQKtfA9DaZUD2jOWgNe2Q_pTdKKZdK7ZJdzYFyrifk7gnfe_SdK9sMv1YRU3LBZ6W3WQwtZqHJbvrs8f48r5y3zi-yVQwdOp8y28dx99jHsECPyaVDstOUbcKjzTwgL1eXzxc3-fzh-vbifJ7XghVdXismVGWh1mAryZjCEkBUKFlRFLIWShdKMxywnCHOWMWLhlJRS9vUlpaaH5DTte8QZoifOrN0qca2LT2GPhk1_Ccklf8KQXLgoEbh2VpYx5BSxMasoluW8dsANWPTZmh6BAaUGZseLk421n21RPur31Q78NM1_-oWr58uoqlcaMPCpS6NZtiG1R_DH-7IibE</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Wakamatsu, Y</creator><creator>Weston, J A</creator><general>The Company of Biologists Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>Sequential expression and role of Hu RNA-binding proteins during neurogenesis</title><author>Wakamatsu, Y ; Weston, J A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-c7247bd1c91db6227ea114be628886c4798792e88665ee52b38f004c6dfcd0a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>3T3 Cells</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Cell Differentiation</topic><topic>Cell Division</topic><topic>Cells, Cultured</topic><topic>Chick Embryo</topic><topic>Coturnix</topic><topic>ELAV Proteins</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genetic Markers</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Mice</topic><topic>Molecular Sequence Data</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Nervous System - cytology</topic><topic>Nervous System - embryology</topic><topic>Nervous System - metabolism</topic><topic>Neural Crest - cytology</topic><topic>Neural Crest - metabolism</topic><topic>Neurons - cytology</topic><topic>Neurons - metabolism</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA-Binding Proteins - genetics</topic><topic>RNA-Binding Proteins - metabolism</topic><topic>Sequence Homology, Amino Acid</topic><topic>Species Specificity</topic><topic>Transfection</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wakamatsu, Y</creatorcontrib><creatorcontrib>Weston, J A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wakamatsu, Y</au><au>Weston, J A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequential expression and role of Hu RNA-binding proteins during neurogenesis</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>124</volume><issue>17</issue><spage>3449</spage><epage>3460</epage><pages>3449-3460</pages><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>We have identified three avian (chicken) Hu/elav family RNA-binding protein genes. cHuD and cHuC are expressed specifically in neurons of both the central and peripheral nervous systems. Although cHuA is expressed in a wide variety of tissues, including neurogenic precursor cells, it is transiently down-regulated, and is then re-expressed in maturing neurons. Misexpression of cHuD in cultured neural crest cells results in a dramatic increase in the proportion of cells exhibiting neuronal morphology, molecular markers for neurons, and neurotrophin dependence. These data confirm that cHuD protein is involved in regulating neuronal differentiation.</abstract><cop>England</cop><pub>The Company of Biologists Limited</pub><pmid>9310339</pmid><doi>10.1242/dev.124.17.3449</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-1991 |
| ispartof | Development (Cambridge), 1997-09, Vol.124 (17), p.3449-3460 |
| issn | 0950-1991 1477-9129 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79314606 |
| source | Company of Biologists,COB,生物学家联盟; MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | 3T3 Cells Amino Acid Sequence Animals Apoptosis Cell Differentiation Cell Division Cells, Cultured Chick Embryo Coturnix ELAV Proteins Gene Expression Regulation, Developmental Genetic Markers Humans In Situ Hybridization Mice Molecular Sequence Data Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous System - cytology Nervous System - embryology Nervous System - metabolism Neural Crest - cytology Neural Crest - metabolism Neurons - cytology Neurons - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Sequence Homology, Amino Acid Species Specificity Transfection |
| title | Sequential expression and role of Hu RNA-binding proteins during neurogenesis |
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