Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas

Amplification and overexpression of genes involved in cellular growth control occur frequently in human cancers. Here, we report characterization of the full length OS4 cDNA derived from 12q13-q15 (Su et al., Proc. Natl. Acad. Sci. USA, 91: 9121-9125, 1994), a region frequently amplified in sarcomas...

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Veröffentlicht in:	Oncogene 1997-09, Vol.15 (11), p.1289-1294
Hauptverfasser:	SU, Y. A, LEE, M. M, HUTTER, C. M, MELTZER, P. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Blotting, Southern Brain tumors Caenorhabditis elegans Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Conserved Sequence Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - genetics Evolution, Molecular Fundamental and applied biological sciences. Psychology Gene Amplification Gene Expression Regulation, Neoplastic Humans Molecular and cellular biology Molecular Sequence Data Molecular weight Nuclear Proteins Open reading frames Phosphoprotein Phosphatases Proteins - genetics Proteins - metabolism Proto-Oncogene Proteins Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Sarcoma Sarcoma - genetics Schizosaccharomyces pombe Sequence Analysis, DNA Tissue Distribution Tumor cell lines Tumor Cells, Cultured
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