Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/ CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia

We have sequenced the breakpoint regions in one acute myeloid leukemia (AML) with t(16;21)(p11;q22) resulting in the formation of a FUS/ERG hybrid gene and in four myxoid liposarcomas (MLS), three of which had the translocation t(12;16) (q13;p11) and a FUS/CHOP fusion gene and one with t(12;22;20)(q...

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Veröffentlicht in:	Oncogene 1997-09, Vol.15 (11), p.1357-1362
Hauptverfasser:	PANAGOPOULOS, I, LASSEN, C, ISAKSSON, M, MITELMAN, F, MANDAHL, N, AMAN, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute myeloid leukemia Base Sequence Biological and medical sciences Breakpoints CCAAT-Enhancer-Binding Proteins Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes DNA Primers DNA-binding protein DNA-Binding Proteins - genetics Fundamental and applied biological sciences. Psychology FUS gene Fusion protein Genes Heterogeneous-Nuclear Ribonucleoproteins Humans Leukemia Leukemia, Myeloid - genetics Liposarcoma Liposarcoma, Myxoid - genetics Molecular and cellular biology Molecular Sequence Data Oncogene Proteins, Fusion - genetics Polymerase Chain Reaction - methods Recombination Ribonucleoproteins - genetics RNA-Binding Protein EWS RNA-Binding Protein FUS Transcription Factor CHOP Transcription Factors - genetics Translocation, Genetic
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