Vaccination against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides

Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system mediated by CD4$^{+}$ T cells reactive with myelin basic protein (MBP). Rats were rendered resistant to the induction of EAE by vaccination with synthetic peptides corresponding to idiotypic determin...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1989-11, Vol.246 (4930), p.668-670
Hauptverfasser:	Howell, Mark D., Winters, Steven T., Olee, Tsaiwei, Powell, Henry C., Carlo, Dennis J., Brostoff, Steven W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animal models Animals Antibodies Antigen receptors, T cell Autoimmunity (experimental aspects and models) Biological and medical sciences Biology Cell lines Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - prevention & control Fundamental and applied biological sciences. Psychology Fundamental immunology Histology Immunity (Disease) Immunotherapy Macromolecular Substances Mice Mice, Inbred Strains Molecular Sequence Data Peptides - administration & dosage Peptides - chemical synthesis Peptides - immunology Prevention Rats Rats, Inbred Lew Receptors Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Sequence Homology, Nucleic Acid T cell antigen receptors T cell receptor genes T cells T lymphocytes Ubiquitins Vaccination Vaccines
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