Vaccination against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides
Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system mediated by CD4$^{+}$ T cells reactive with myelin basic protein (MBP). Rats were rendered resistant to the induction of EAE by vaccination with synthetic peptides corresponding to idiotypic determin...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1989-11, Vol.246 (4930), p.668-670 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Howell, Mark D. Winters, Steven T. Olee, Tsaiwei Powell, Henry C. Carlo, Dennis J. Brostoff, Steven W. |
| description | Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system mediated by CD4$^{+}$ T cells reactive with myelin basic protein (MBP). Rats were rendered resistant to the induction of EAE by vaccination with synthetic peptides corresponding to idiotypic determinants of the $\beta $ chain VDJ region and J$\alpha $ regions of the T cell receptor (TCR) that are conserved among encephalitogenic T cells. These findings demonstrate the utility of TCR peptide vaccination for modulating the activity of autoreactive T cells and represent a general therapeutic approach for T cell--mediated pathogenesis. |
| doi_str_mv | 10.1126/science.2814489 |
| format | Article |
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Rats were rendered resistant to the induction of EAE by vaccination with synthetic peptides corresponding to idiotypic determinants of the $\beta $ chain VDJ region and J$\alpha $ regions of the T cell receptor (TCR) that are conserved among encephalitogenic T cells. These findings demonstrate the utility of TCR peptide vaccination for modulating the activity of autoreactive T cells and represent a general therapeutic approach for T cell--mediated pathogenesis.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.2814489</identifier><identifier>PMID: 2814489</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: The American Association for the Advancement of Science</publisher><subject>Amino Acid Sequence ; Animal models ; Animals ; Antibodies ; Antigen receptors, T cell ; Autoimmunity (experimental aspects and models) ; Biological and medical sciences ; Biology ; Cell lines ; Encephalomyelitis ; Encephalomyelitis, Autoimmune, Experimental - immunology ; Encephalomyelitis, Autoimmune, Experimental - prevention & control ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Histology ; Immunity (Disease) ; Immunotherapy ; Macromolecular Substances ; Mice ; Mice, Inbred Strains ; Molecular Sequence Data ; Peptides - administration & dosage ; Peptides - chemical synthesis ; Peptides - immunology ; Prevention ; Rats ; Rats, Inbred Lew ; Receptors ; Receptors, Antigen, T-Cell - genetics ; Receptors, Antigen, T-Cell - immunology ; Sequence Homology, Nucleic Acid ; T cell antigen receptors ; T cell receptor genes ; T cells ; T lymphocytes ; Ubiquitins ; Vaccination ; Vaccines</subject><ispartof>Science (American Association for the Advancement of Science), 1989-11, Vol.246 (4930), p.668-670</ispartof><rights>Copyright 1989 The American Association for the Advancement of Science</rights><rights>1990 INIST-CNRS</rights><rights>COPYRIGHT 1989 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1989 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Nov 3, 1989</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c698t-ec4d1760c68c6f307b55cdc500a9a666fd0b139251f7dc6edaf600a1db74a66c3</citedby><cites>FETCH-LOGICAL-c698t-ec4d1760c68c6f307b55cdc500a9a666fd0b139251f7dc6edaf600a1db74a66c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1704863$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1704863$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6800082$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2814489$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Howell, Mark D.</creatorcontrib><creatorcontrib>Winters, Steven T.</creatorcontrib><creatorcontrib>Olee, Tsaiwei</creatorcontrib><creatorcontrib>Powell, Henry C.</creatorcontrib><creatorcontrib>Carlo, Dennis J.</creatorcontrib><creatorcontrib>Brostoff, Steven W.</creatorcontrib><title>Vaccination against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system mediated by CD4$^{+}$ T cells reactive with myelin basic protein (MBP). Rats were rendered resistant to the induction of EAE by vaccination with synthetic peptides corresponding to idiotypic determinants of the $\beta $ chain VDJ region and J$\alpha $ regions of the T cell receptor (TCR) that are conserved among encephalitogenic T cells. These findings demonstrate the utility of TCR peptide vaccination for modulating the activity of autoreactive T cells and represent a general therapeutic approach for T cell--mediated pathogenesis.</description><subject>Amino Acid Sequence</subject><subject>Animal models</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antigen receptors, T cell</subject><subject>Autoimmunity (experimental aspects and models)</subject><subject>Biological and medical sciences</subject><subject>Biology</subject><subject>Cell lines</subject><subject>Encephalomyelitis</subject><subject>Encephalomyelitis, Autoimmune, Experimental - immunology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - prevention & control</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Histology</subject><subject>Immunity (Disease)</subject><subject>Immunotherapy</subject><subject>Macromolecular Substances</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Molecular Sequence Data</subject><subject>Peptides - administration & dosage</subject><subject>Peptides - chemical synthesis</subject><subject>Peptides - immunology</subject><subject>Prevention</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Receptors</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>Receptors, Antigen, T-Cell - immunology</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>T cell antigen receptors</subject><subject>T cell receptor genes</subject><subject>T cells</subject><subject>T lymphocytes</subject><subject>Ubiquitins</subject><subject>Vaccination</subject><subject>Vaccines</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN00Fv0zAYBuAIgUYZnLmAFE0IDqObHceOcyxVKZMqimBM4hS5zpfMVeIU2xHbv-erGm0DVVqVg6W8j2MnfhNFryk5ozQR514bsBrOEknTVOZPohElOR_nCWFPoxEhTIwlyfjz6IX3a0Iwy9lRdDTwUfTrSmltrAqms7GqlbE-xLObDTjTgg2qiSdNA642Op7hOptr1XTtLTQmGB__MeE6voyn0DTxd8A0dC7-hoMpwb-MnlWq8fBqGI-jn59nl9Mv48VyfjGdLMZa5DKMQaclzQTRQmpRMZKtONel5oSoXAkhqpKsKMsTTqus1AJKVQnMaLnKUsw1O47e7567cd3vHnwoWuM1bklZ6HpfZDmjSULlo5AJRoRIxaMwoZSxXGzhyX9w3fXO4tuiYZylnG_R6Q7VqoHC2KoLTukaLDj8lhYqg7cnkmYZZwz1xz0arxJao_fwD_9wFAFuQq1674uLH18PlcurQ-Wn-YFSzhcP5ek-qTssVw0FFmK6fKjPd1q7znsHVbHBOip3W1BSbGtfDLUvhh7jjLfDSfSrFso7f5-_G3LltWoqp6w2_o4Jib-GTJC92bG1xyrfr5qRVArG_gJXqREO</recordid><startdate>19891103</startdate><enddate>19891103</enddate><creator>Howell, Mark D.</creator><creator>Winters, Steven T.</creator><creator>Olee, Tsaiwei</creator><creator>Powell, Henry C.</creator><creator>Carlo, Dennis J.</creator><creator>Brostoff, Steven W.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7T5</scope><scope>7X8</scope></search><sort><creationdate>19891103</creationdate><title>Vaccination against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides</title><author>Howell, Mark D. ; 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Psychology</topic><topic>Fundamental immunology</topic><topic>Histology</topic><topic>Immunity (Disease)</topic><topic>Immunotherapy</topic><topic>Macromolecular Substances</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Molecular Sequence Data</topic><topic>Peptides - administration & dosage</topic><topic>Peptides - chemical synthesis</topic><topic>Peptides - immunology</topic><topic>Prevention</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Receptors</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>T cell antigen receptors</topic><topic>T cell receptor genes</topic><topic>T cells</topic><topic>T lymphocytes</topic><topic>Ubiquitins</topic><topic>Vaccination</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Howell, Mark D.</creatorcontrib><creatorcontrib>Winters, 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Tsaiwei</au><au>Powell, Henry C.</au><au>Carlo, Dennis J.</au><au>Brostoff, Steven W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vaccination against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1989-11-03</date><risdate>1989</risdate><volume>246</volume><issue>4930</issue><spage>668</spage><epage>670</epage><pages>668-670</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Experimental allergic encephalomyelitis (EAE) is an autoimmune disease of the central nervous system mediated by CD4$^{+}$ T cells reactive with myelin basic protein (MBP). Rats were rendered resistant to the induction of EAE by vaccination with synthetic peptides corresponding to idiotypic determinants of the $\beta $ chain VDJ region and J$\alpha $ regions of the T cell receptor (TCR) that are conserved among encephalitogenic T cells. These findings demonstrate the utility of TCR peptide vaccination for modulating the activity of autoreactive T cells and represent a general therapeutic approach for T cell--mediated pathogenesis.</abstract><cop>Washington, DC</cop><pub>The American Association for the Advancement of Science</pub><pmid>2814489</pmid><doi>10.1126/science.2814489</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1989-11, Vol.246 (4930), p.668-670 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79312218 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Amino Acid Sequence Animal models Animals Antibodies Antigen receptors, T cell Autoimmunity (experimental aspects and models) Biological and medical sciences Biology Cell lines Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - prevention & control Fundamental and applied biological sciences. Psychology Fundamental immunology Histology Immunity (Disease) Immunotherapy Macromolecular Substances Mice Mice, Inbred Strains Molecular Sequence Data Peptides - administration & dosage Peptides - chemical synthesis Peptides - immunology Prevention Rats Rats, Inbred Lew Receptors Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Sequence Homology, Nucleic Acid T cell antigen receptors T cell receptor genes T cells T lymphocytes Ubiquitins Vaccination Vaccines |
| title | Vaccination against Experimental Allergic Encephalomyelitis with T Cell Receptor Peptides |
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