Anti-aids agents—XXVI. Structure-activity correlations of Gomisin-G-related anti-HIV lignans from Kadsura interior and of related synthetic analogues

Bioactivity-directed fractionation of an ethanolic extract of the stems of Kadsura interior led to the isolation and identification of 12 known lignans ( 1– 12). Seven of these compounds ( 1, 6, 8– 12) were active as anti-HIV agents. Gomisin-G ( 11) exhibited the most potent anti-HIV activity with E...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 1997-08, Vol.5 (8), p.1715-1723
Hauptverfasser:	Chen, Dao-Feng, Zhang, Shun-Xiang, Xie, Lan, Xie, Jing-Xi, Chen, Ke, Kashiwada, Yoshiki, Zhou, Bing-Nan, Wang, Pei, Cosentino, L.Mark, Lee, Kuo-Hsiung
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - chemistry Anti-HIV Agents - pharmacology Cell Line Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Enzyme-Linked Immunosorbent Assay Humans Lignans - chemistry Lignans - pharmacology Magnetic Resonance Spectroscopy Structure-Activity Relationship Trees
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