Exercise Training Reverses the Age-Related Decline in Tyrosine Hydroxylase Expression in Rat Hypothalamus
Tyrosine hydroxylase (TH) is the rate-limiting enzymatic step in the catecholamine biosynthesis pathway. Some studies have demonstrated that aging is associated with a decrease in TH activity and TH mRNA in rat hypothalamus. We previously demonstrated that exercise training can decrease TH gene expr...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 1997-09, Vol.52A (5), p.B255-B259 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Türner, Nihal LaRochelle, Jeffrey S. Yürekli, Muhittin |
| description | Tyrosine hydroxylase (TH) is the rate-limiting enzymatic step in the catecholamine biosynthesis pathway. Some studies have demonstrated that aging is associated with a decrease in TH activity and TH mRNA in rat hypothalamus. We previously demonstrated that exercise training can decrease TH gene expression in the adrenal medulla of young but not senescent rats. This study was designed to examine the effects of endurance training on the TH expression in hypothalamus with aging. To this end, we assessed TH mRNA, TH immunoreactivity, and TH activity with or without exercise training. Young and old F-344 female rats were trained by treadmill running for 8 weeks. All parameters examined were significantly lower in hypothalamus of old (25-month) compared with young (5-month) control animals (p < .05). Exercise training significantly elevated TH mRNA (n = 5–7 in each group), TH immunoreactivity (n = 5–8 in each group), and TH activity (n = 12–13 young groups and n = 6 old groups) in the hypothalamus of old animals (p < .05), but there was no significant change in any of these parameters in young animals following training. These data indicate that endurance training can reverse the age-related decline in catecholamine biosynthesis in the hypothalamus. |
| doi_str_mv | 10.1093/gerona/52A.5.B255 |
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Some studies have demonstrated that aging is associated with a decrease in TH activity and TH mRNA in rat hypothalamus. We previously demonstrated that exercise training can decrease TH gene expression in the adrenal medulla of young but not senescent rats. This study was designed to examine the effects of endurance training on the TH expression in hypothalamus with aging. To this end, we assessed TH mRNA, TH immunoreactivity, and TH activity with or without exercise training. Young and old F-344 female rats were trained by treadmill running for 8 weeks. All parameters examined were significantly lower in hypothalamus of old (25-month) compared with young (5-month) control animals (p < .05). Exercise training significantly elevated TH mRNA (n = 5–7 in each group), TH immunoreactivity (n = 5–8 in each group), and TH activity (n = 12–13 young groups and n = 6 old groups) in the hypothalamus of old animals (p < .05), but there was no significant change in any of these parameters in young animals following training. These data indicate that endurance training can reverse the age-related decline in catecholamine biosynthesis in the hypothalamus.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/52A.5.B255</identifier><identifier>PMID: 9310075</identifier><language>eng</language><publisher>United States: The Gerontological Society of America</publisher><subject>Aging - metabolism ; Animals ; Brain ; Catecholamines - biosynthesis ; Cellular biology ; Enzymes ; Exercise ; Female ; Hypothalamus - enzymology ; Physical Conditioning, Animal ; Rats ; Rats, Inbred F344 ; RNA, Messenger - analysis ; Rodents ; Tyrosine 3-Monooxygenase - genetics ; Tyrosine 3-Monooxygenase - metabolism</subject><ispartof>The journals of gerontology. 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Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Tyrosine hydroxylase (TH) is the rate-limiting enzymatic step in the catecholamine biosynthesis pathway. Some studies have demonstrated that aging is associated with a decrease in TH activity and TH mRNA in rat hypothalamus. We previously demonstrated that exercise training can decrease TH gene expression in the adrenal medulla of young but not senescent rats. This study was designed to examine the effects of endurance training on the TH expression in hypothalamus with aging. To this end, we assessed TH mRNA, TH immunoreactivity, and TH activity with or without exercise training. Young and old F-344 female rats were trained by treadmill running for 8 weeks. All parameters examined were significantly lower in hypothalamus of old (25-month) compared with young (5-month) control animals (p < .05). Exercise training significantly elevated TH mRNA (n = 5–7 in each group), TH immunoreactivity (n = 5–8 in each group), and TH activity (n = 12–13 young groups and n = 6 old groups) in the hypothalamus of old animals (p < .05), but there was no significant change in any of these parameters in young animals following training. These data indicate that endurance training can reverse the age-related decline in catecholamine biosynthesis in the hypothalamus.</description><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Brain</subject><subject>Catecholamines - biosynthesis</subject><subject>Cellular biology</subject><subject>Enzymes</subject><subject>Exercise</subject><subject>Female</subject><subject>Hypothalamus - enzymology</subject><subject>Physical Conditioning, Animal</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>RNA, Messenger - analysis</subject><subject>Rodents</subject><subject>Tyrosine 3-Monooxygenase - genetics</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNp1kU9rGzEQxUVpyb_2A_RQWFrIbR1p5VlJRyd14kJoqfEh5CLG2omjZL3rSLvB_vbRYpNDoXOZgfebx0iPsa-CjwQ38mJFoW3wAorJCEaXBcAHdiIU6Bwk3H1MM1cmB87LY3Ya4xMfCoojdmSk4FzBCfPTLQXnI2WLgL7xzSqb0yuFSDHrHimbrCifU40dVdlPcrVvKPNNttiFNg7zbFeFdrurMTlMt5tAMfq2GZA5dkndtN0j1rju42f26QHrSF8O_YwtrqeLq1l---fm19XkNndjWXQ5oC4KGMtSOgLCCoVwYunGREoZB0ZL5BUsFXItDBfSAJWJ16ClXiKXZ-x8b7sJ7UtPsbNrHx3VNTbU9tGq9HQhlU7g93_Ap7YPTTrNFlyXQhslE_Tjf5DQSol0Ah-sxJ5y6VdioAe7CX6NYWcFt0NQdh-UTUFZsENQaefbwblfrql63zgkk_R8r_vY0fZdxvBsSyUV2Nndvb3nRv29uf5thXwD-3-eXw</recordid><startdate>19970901</startdate><enddate>19970901</enddate><creator>Türner, Nihal</creator><creator>LaRochelle, Jeffrey S.</creator><creator>Yürekli, Muhittin</creator><general>The Gerontological Society of America</general><general>Gerontological Society of America</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOIBA</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19970901</creationdate><title>Exercise Training Reverses the Age-Related Decline in Tyrosine Hydroxylase Expression in Rat Hypothalamus</title><author>Türner, Nihal ; 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Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Türner, Nihal</au><au>LaRochelle, Jeffrey S.</au><au>Yürekli, Muhittin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise Training Reverses the Age-Related Decline in Tyrosine Hydroxylase Expression in Rat Hypothalamus</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>1997-09-01</date><risdate>1997</risdate><volume>52A</volume><issue>5</issue><spage>B255</spage><epage>B259</epage><pages>B255-B259</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Tyrosine hydroxylase (TH) is the rate-limiting enzymatic step in the catecholamine biosynthesis pathway. Some studies have demonstrated that aging is associated with a decrease in TH activity and TH mRNA in rat hypothalamus. We previously demonstrated that exercise training can decrease TH gene expression in the adrenal medulla of young but not senescent rats. This study was designed to examine the effects of endurance training on the TH expression in hypothalamus with aging. To this end, we assessed TH mRNA, TH immunoreactivity, and TH activity with or without exercise training. Young and old F-344 female rats were trained by treadmill running for 8 weeks. All parameters examined were significantly lower in hypothalamus of old (25-month) compared with young (5-month) control animals (p < .05). Exercise training significantly elevated TH mRNA (n = 5–7 in each group), TH immunoreactivity (n = 5–8 in each group), and TH activity (n = 12–13 young groups and n = 6 old groups) in the hypothalamus of old animals (p < .05), but there was no significant change in any of these parameters in young animals following training. These data indicate that endurance training can reverse the age-related decline in catecholamine biosynthesis in the hypothalamus.</abstract><cop>United States</cop><pub>The Gerontological Society of America</pub><pmid>9310075</pmid><doi>10.1093/gerona/52A.5.B255</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1079-5006 |
| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 1997-09, Vol.52A (5), p.B255-B259 |
| issn | 1079-5006 1758-535X |
| language | eng |
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| source | MEDLINE; Periodicals Index Online; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aging - metabolism Animals Brain Catecholamines - biosynthesis Cellular biology Enzymes Exercise Female Hypothalamus - enzymology Physical Conditioning, Animal Rats Rats, Inbred F344 RNA, Messenger - analysis Rodents Tyrosine 3-Monooxygenase - genetics Tyrosine 3-Monooxygenase - metabolism |
| title | Exercise Training Reverses the Age-Related Decline in Tyrosine Hydroxylase Expression in Rat Hypothalamus |
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