Aging, physical activity, insulin-like growth factor I, and body composition in Guatemalan women
Aging is associated with diminished secretion of growth hormone and the major endogenous mediator of growth hormone action, insulin-like growth factor I (IGF-I). Aging is also associated with decreased physical activity. Alterations in body composition characteristic of the aging process (increased...
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| Veröffentlicht in: | The American journal of clinical nutrition 1997-10, Vol.66 (4), p.874-879 |
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| creator | Porch, JV Jain, K Reilly, A Valdez, C Mazariegos, M Ziegler, TR Solomons, N Smith, RJ |
| description | Aging is associated with diminished secretion of growth hormone and the major endogenous mediator of growth hormone action, insulin-like growth factor I (IGF-I). Aging is also associated with decreased physical activity. Alterations in body composition characteristic of the aging process (increased fat mass and decreased lean body mass) may be related to the decline in anabolic effects of IGF-I with aging, decreased physical activity, or both. Guatemalan women often maintain a high level of physical activity during aging. The purpose of this study was to determine whether IGF-I concentrations correlated with physical activity level (determined by standardized scoring of a self-report questionnaire) and body composition (determined by bioelectrical impedance analysis) in elderly Guatemalan women. In 112 women aged 20-87 y, we found a progressively lower serum IGF-I with age (r = -0.732). In subjects > 60 y of age, the self-reported activity level was associated with a lower percentage body fat (P < 0.001) but there was no significant relation between physical activity level and either lean body mass or IGF-I. We conclude that there is a significant age-related decline in serum IGF-I concentrations in Guatemalan women, similar to that observed in both men and women in the United States. An increased level of physical activity in the elderly Guatemalan population was associated with reduced body fat but did not modify the expected reduction in circulating IGF-I concentrations that occurs with aging. |
| doi_str_mv | 10.1093/ajcn/66.4.874 |
| format | Article |
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Aging is also associated with decreased physical activity. Alterations in body composition characteristic of the aging process (increased fat mass and decreased lean body mass) may be related to the decline in anabolic effects of IGF-I with aging, decreased physical activity, or both. Guatemalan women often maintain a high level of physical activity during aging. The purpose of this study was to determine whether IGF-I concentrations correlated with physical activity level (determined by standardized scoring of a self-report questionnaire) and body composition (determined by bioelectrical impedance analysis) in elderly Guatemalan women. In 112 women aged 20-87 y, we found a progressively lower serum IGF-I with age (r = -0.732). In subjects > 60 y of age, the self-reported activity level was associated with a lower percentage body fat (P < 0.001) but there was no significant relation between physical activity level and either lean body mass or IGF-I. We conclude that there is a significant age-related decline in serum IGF-I concentrations in Guatemalan women, similar to that observed in both men and women in the United States. An increased level of physical activity in the elderly Guatemalan population was associated with reduced body fat but did not modify the expected reduction in circulating IGF-I concentrations that occurs with aging.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/66.4.874</identifier><identifier>PMID: 9322563</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging ; Aging - blood ; Aging - metabolism ; Aging - physiology ; Biological and medical sciences ; Body Composition - physiology ; Body Constitution ; Cohort Studies ; Cross-Sectional Studies ; Female ; Fundamental and applied biological sciences. Psychology ; Guatemala ; Humans ; Insulin-Like Growth Factor I - analysis ; Insulin-Like Growth Factor I - metabolism ; Intermediate and energetic metabolism ; Medical research ; Metabolism ; Metabolisms and neurohumoral controls ; Middle Aged ; Older people ; Physical fitness ; Physical Fitness - physiology ; Regression Analysis ; Rural Population ; Urban Population ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Women</subject><ispartof>The American journal of clinical nutrition, 1997-10, Vol.66 (4), p.874-879</ispartof><rights>1997 American Society for Nutrition.</rights><rights>1997 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. 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Aging is also associated with decreased physical activity. Alterations in body composition characteristic of the aging process (increased fat mass and decreased lean body mass) may be related to the decline in anabolic effects of IGF-I with aging, decreased physical activity, or both. Guatemalan women often maintain a high level of physical activity during aging. The purpose of this study was to determine whether IGF-I concentrations correlated with physical activity level (determined by standardized scoring of a self-report questionnaire) and body composition (determined by bioelectrical impedance analysis) in elderly Guatemalan women. In 112 women aged 20-87 y, we found a progressively lower serum IGF-I with age (r = -0.732). In subjects > 60 y of age, the self-reported activity level was associated with a lower percentage body fat (P < 0.001) but there was no significant relation between physical activity level and either lean body mass or IGF-I. We conclude that there is a significant age-related decline in serum IGF-I concentrations in Guatemalan women, similar to that observed in both men and women in the United States. An increased level of physical activity in the elderly Guatemalan population was associated with reduced body fat but did not modify the expected reduction in circulating IGF-I concentrations that occurs with aging.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Aging - blood</subject><subject>Aging - metabolism</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Body Composition - physiology</subject><subject>Body Constitution</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guatemala</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - analysis</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Intermediate and energetic metabolism</subject><subject>Medical research</subject><subject>Metabolism</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Physical fitness</subject><subject>Physical Fitness - physiology</subject><subject>Regression Analysis</subject><subject>Rural Population</subject><subject>Urban Population</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Women</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1rFDEYxoModa0ePQpBxNPONh8z-TiWorVQ8KLnmEne2WadSdZkpmX_e7Ps0oPgJTk8v_fh4YfQe0o2lGh-ZXcuXgmxaTdKti_QimquGs6IfIlWhBDWaCq61-hNKTtCKGuVuEAXmjPWCb5Cv663IW7XeP9wKMHZEVs3h8cwH9Y4xLKMITZj-A14m9PT_ICHGqeM79bYRo_75A_YpWmfSphDivUE3y52hsmONuKnNEF8i14Ndizw7vxfop9fv_y4-dbcf7-9u7m-b1zL6dxAndoyZZVSvXeSEQvKUl4f4onzQnfceyEpl9IOnvV9p2g3AAXQXDJH-SX6fOrd5_RngTKbKRQHYx0CaSlGal51aVHBj_-Au7TkWLcZxqlmrGXHtuYEuZxKyTCYfQ6TzQdDiTlqN0ftRgjTmqq98h_OpUs_gX-mz55r_umc21ItD9lGF8ozxlTLSccqJk8YVFOPAbIpLkB04EMGNxufwn8G_AXW3p2r</recordid><startdate>19971001</startdate><enddate>19971001</enddate><creator>Porch, JV</creator><creator>Jain, K</creator><creator>Reilly, A</creator><creator>Valdez, C</creator><creator>Mazariegos, M</creator><creator>Ziegler, TR</creator><creator>Solomons, N</creator><creator>Smith, RJ</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19971001</creationdate><title>Aging, physical activity, insulin-like growth factor I, and body composition in Guatemalan women</title><author>Porch, JV ; Jain, K ; Reilly, A ; Valdez, C ; Mazariegos, M ; Ziegler, TR ; Solomons, N ; Smith, RJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-e000428a888bdc720ae8a13e8a0d0cd6953dd671377afd2bb5815fe1ee9372c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Aging - blood</topic><topic>Aging - metabolism</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Body Composition - physiology</topic><topic>Body Constitution</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guatemala</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - analysis</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Intermediate and energetic metabolism</topic><topic>Medical research</topic><topic>Metabolism</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Physical fitness</topic><topic>Physical Fitness - physiology</topic><topic>Regression Analysis</topic><topic>Rural Population</topic><topic>Urban Population</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Porch, JV</creatorcontrib><creatorcontrib>Jain, K</creatorcontrib><creatorcontrib>Reilly, A</creatorcontrib><creatorcontrib>Valdez, C</creatorcontrib><creatorcontrib>Mazariegos, M</creatorcontrib><creatorcontrib>Ziegler, TR</creatorcontrib><creatorcontrib>Solomons, N</creatorcontrib><creatorcontrib>Smith, RJ</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Porch, JV</au><au>Jain, K</au><au>Reilly, A</au><au>Valdez, C</au><au>Mazariegos, M</au><au>Ziegler, TR</au><au>Solomons, N</au><au>Smith, RJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aging, physical activity, insulin-like growth factor I, and body composition in Guatemalan women</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1997-10-01</date><risdate>1997</risdate><volume>66</volume><issue>4</issue><spage>874</spage><epage>879</epage><pages>874-879</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Aging is associated with diminished secretion of growth hormone and the major endogenous mediator of growth hormone action, insulin-like growth factor I (IGF-I). Aging is also associated with decreased physical activity. Alterations in body composition characteristic of the aging process (increased fat mass and decreased lean body mass) may be related to the decline in anabolic effects of IGF-I with aging, decreased physical activity, or both. Guatemalan women often maintain a high level of physical activity during aging. The purpose of this study was to determine whether IGF-I concentrations correlated with physical activity level (determined by standardized scoring of a self-report questionnaire) and body composition (determined by bioelectrical impedance analysis) in elderly Guatemalan women. In 112 women aged 20-87 y, we found a progressively lower serum IGF-I with age (r = -0.732). In subjects > 60 y of age, the self-reported activity level was associated with a lower percentage body fat (P < 0.001) but there was no significant relation between physical activity level and either lean body mass or IGF-I. We conclude that there is a significant age-related decline in serum IGF-I concentrations in Guatemalan women, similar to that observed in both men and women in the United States. An increased level of physical activity in the elderly Guatemalan population was associated with reduced body fat but did not modify the expected reduction in circulating IGF-I concentrations that occurs with aging.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>9322563</pmid><doi>10.1093/ajcn/66.4.874</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Aging Aging - blood Aging - metabolism Aging - physiology Biological and medical sciences Body Composition - physiology Body Constitution Cohort Studies Cross-Sectional Studies Female Fundamental and applied biological sciences. Psychology Guatemala Humans Insulin-Like Growth Factor I - analysis Insulin-Like Growth Factor I - metabolism Intermediate and energetic metabolism Medical research Metabolism Metabolisms and neurohumoral controls Middle Aged Older people Physical fitness Physical Fitness - physiology Regression Analysis Rural Population Urban Population Vertebrates: anatomy and physiology, studies on body, several organs or systems Women |
| title | Aging, physical activity, insulin-like growth factor I, and body composition in Guatemalan women |
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