EFFECTS OF INDOMETHACIN ON EPIDERMAL GROWTH FACTOR-INDUCED RENAL RESPONSES IN SHEEP
SUMMARY 1. The effects of indomethacin (an inhibitor of prostaglandin synthesis) on the renal responses to epidermal growth factor (EGF) were investigated in conscious sheep. 2. Ewes (n = 5 per group) received an i.v. saline infusion (150 mL/day) for days 1‐8, followed by either vehicle control, 15...
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| Veröffentlicht in: | Clinical and experimental pharmacology & physiology 1997-10, Vol.24 (9-10), p.680-685 |
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| creator | Gow, Christine B. Grant, Sharon L. Phillips, Paddy A. |
| description | SUMMARY
1. The effects of indomethacin (an inhibitor of prostaglandin synthesis) on the renal responses to epidermal growth factor (EGF) were investigated in conscious sheep.
2. Ewes (n = 5 per group) received an i.v. saline infusion (150 mL/day) for days 1‐8, followed by either vehicle control, 15 μg/h EGF, 2mg/kg per day indomethacin or 15 μg/h EGF with 2 mg/kg per day indomethacin in 150 mL/day saline, i.v., over days 9‐12. All ewes subsequently received an i.v. saline infusion (150 mL/day) over days 13‐20.
3. Polydipsia, diuresis, transient natriuresis and reduced urine osmolality occurred during EGF treatment alone. There was no effect of EGF on fluid balance, plasma electrolyte or hormone concentrations, plasma osmolality or haematocrit or on the urinary excretion of potassium.
4. Simultaneous infusion of indomethacin with EGF attenuated (P>0.05) the stimulatory effects of EGF infusion alone on urine volume, water intake, natriuresis and urine osmolality.
5. We conclude that prostaglandins may be involved in the diuretic/natriuretic effects of EGF, but may not be the sole mechanism involved. |
| doi_str_mv | 10.1111/j.1440-1681.1997.tb02112.x |
| format | Article |
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1. The effects of indomethacin (an inhibitor of prostaglandin synthesis) on the renal responses to epidermal growth factor (EGF) were investigated in conscious sheep.
2. Ewes (n = 5 per group) received an i.v. saline infusion (150 mL/day) for days 1‐8, followed by either vehicle control, 15 μg/h EGF, 2mg/kg per day indomethacin or 15 μg/h EGF with 2 mg/kg per day indomethacin in 150 mL/day saline, i.v., over days 9‐12. All ewes subsequently received an i.v. saline infusion (150 mL/day) over days 13‐20.
3. Polydipsia, diuresis, transient natriuresis and reduced urine osmolality occurred during EGF treatment alone. There was no effect of EGF on fluid balance, plasma electrolyte or hormone concentrations, plasma osmolality or haematocrit or on the urinary excretion of potassium.
4. Simultaneous infusion of indomethacin with EGF attenuated (P>0.05) the stimulatory effects of EGF infusion alone on urine volume, water intake, natriuresis and urine osmolality.
5. We conclude that prostaglandins may be involved in the diuretic/natriuretic effects of EGF, but may not be the sole mechanism involved.</description><identifier>ISSN: 0305-1870</identifier><identifier>EISSN: 1440-1681</identifier><identifier>DOI: 10.1111/j.1440-1681.1997.tb02112.x</identifier><identifier>PMID: 9315369</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Anti-Inflammatory Agents, Non-Steroidal - blood ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Appetite - drug effects ; Diuresis - drug effects ; epidermal growth factor ; Epidermal Growth Factor - blood ; Epidermal Growth Factor - pharmacology ; Female ; indomethacin ; Indomethacin - blood ; Indomethacin - pharmacology ; Kidney - drug effects ; Natriuresis - drug effects ; prostaglandins ; Prostaglandins - metabolism ; Sheep ; Urination - drug effects ; Water-Electrolyte Balance - drug effects</subject><ispartof>Clinical and experimental pharmacology & physiology, 1997-10, Vol.24 (9-10), p.680-685</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4070-61ee7eaf70a20b478137c20929904c64ee65fe016cbf6cce2247ff71259ec49b3</citedby><cites>FETCH-LOGICAL-c4070-61ee7eaf70a20b478137c20929904c64ee65fe016cbf6cce2247ff71259ec49b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1681.1997.tb02112.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1681.1997.tb02112.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9315369$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gow, Christine B.</creatorcontrib><creatorcontrib>Grant, Sharon L.</creatorcontrib><creatorcontrib>Phillips, Paddy A.</creatorcontrib><title>EFFECTS OF INDOMETHACIN ON EPIDERMAL GROWTH FACTOR-INDUCED RENAL RESPONSES IN SHEEP</title><title>Clinical and experimental pharmacology & physiology</title><addtitle>Clin Exp Pharmacol Physiol</addtitle><description>SUMMARY
1. The effects of indomethacin (an inhibitor of prostaglandin synthesis) on the renal responses to epidermal growth factor (EGF) were investigated in conscious sheep.
2. Ewes (n = 5 per group) received an i.v. saline infusion (150 mL/day) for days 1‐8, followed by either vehicle control, 15 μg/h EGF, 2mg/kg per day indomethacin or 15 μg/h EGF with 2 mg/kg per day indomethacin in 150 mL/day saline, i.v., over days 9‐12. All ewes subsequently received an i.v. saline infusion (150 mL/day) over days 13‐20.
3. Polydipsia, diuresis, transient natriuresis and reduced urine osmolality occurred during EGF treatment alone. There was no effect of EGF on fluid balance, plasma electrolyte or hormone concentrations, plasma osmolality or haematocrit or on the urinary excretion of potassium.
4. Simultaneous infusion of indomethacin with EGF attenuated (P>0.05) the stimulatory effects of EGF infusion alone on urine volume, water intake, natriuresis and urine osmolality.
5. We conclude that prostaglandins may be involved in the diuretic/natriuretic effects of EGF, but may not be the sole mechanism involved.</description><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - blood</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Appetite - drug effects</subject><subject>Diuresis - drug effects</subject><subject>epidermal growth factor</subject><subject>Epidermal Growth Factor - blood</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>Female</subject><subject>indomethacin</subject><subject>Indomethacin - blood</subject><subject>Indomethacin - pharmacology</subject><subject>Kidney - drug effects</subject><subject>Natriuresis - drug effects</subject><subject>prostaglandins</subject><subject>Prostaglandins - metabolism</subject><subject>Sheep</subject><subject>Urination - drug effects</subject><subject>Water-Electrolyte Balance - drug effects</subject><issn>0305-1870</issn><issn>1440-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMGO2jAURa2qI0ppP6FSNIvuknmOHTvuYiQUHECCBCWhdGclriPBwEBjUOHvawRiX2-8uPceywehZwwBdudlE2BKwccsxgEWggfHBkKMw-D8AfUf0UfUBwKRj2MOn9BnazcAEAEjPdQTBEeEiT4qZZrKpCq9PPWm2Sify2oyTKaZl2eeXExHspgPZ964yFfVxEuHSZUXvustEznyCpm5rJDlIs9KWbq9V06kXHxBT229tebr_R6gZSqrZOLP8vE0Gc58TYGDz7Ax3NQthzqEhvIYE65DEKEQQDWjxrCoNYCZblqmtQlDytuW4zASRlPRkAH6fuMeuv2fk7FHtVtbbbbb-t3sT1Zx90sQgrjij1tRd3trO9OqQ7fe1d1FYVBXo2qjrtrUVZu6GlV3o-rsxt_ur5yanfn9mN4Vuvz1lv9db83lP8gqkQsWgwP4N8DaHs35Aai7N8U44ZFaZWOVkjmNf7GfakT-Aei4jKA</recordid><startdate>199710</startdate><enddate>199710</enddate><creator>Gow, Christine B.</creator><creator>Grant, Sharon L.</creator><creator>Phillips, Paddy A.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199710</creationdate><title>EFFECTS OF INDOMETHACIN ON EPIDERMAL GROWTH FACTOR-INDUCED RENAL RESPONSES IN SHEEP</title><author>Gow, Christine B. ; Grant, Sharon L. ; Phillips, Paddy A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4070-61ee7eaf70a20b478137c20929904c64ee65fe016cbf6cce2247ff71259ec49b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - blood</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Appetite - drug effects</topic><topic>Diuresis - drug effects</topic><topic>epidermal growth factor</topic><topic>Epidermal Growth Factor - blood</topic><topic>Epidermal Growth Factor - pharmacology</topic><topic>Female</topic><topic>indomethacin</topic><topic>Indomethacin - blood</topic><topic>Indomethacin - pharmacology</topic><topic>Kidney - drug effects</topic><topic>Natriuresis - drug effects</topic><topic>prostaglandins</topic><topic>Prostaglandins - metabolism</topic><topic>Sheep</topic><topic>Urination - drug effects</topic><topic>Water-Electrolyte Balance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gow, Christine B.</creatorcontrib><creatorcontrib>Grant, Sharon L.</creatorcontrib><creatorcontrib>Phillips, Paddy A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental pharmacology & physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gow, Christine B.</au><au>Grant, Sharon L.</au><au>Phillips, Paddy A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF INDOMETHACIN ON EPIDERMAL GROWTH FACTOR-INDUCED RENAL RESPONSES IN SHEEP</atitle><jtitle>Clinical and experimental pharmacology & physiology</jtitle><addtitle>Clin Exp Pharmacol Physiol</addtitle><date>1997-10</date><risdate>1997</risdate><volume>24</volume><issue>9-10</issue><spage>680</spage><epage>685</epage><pages>680-685</pages><issn>0305-1870</issn><eissn>1440-1681</eissn><abstract>SUMMARY
1. The effects of indomethacin (an inhibitor of prostaglandin synthesis) on the renal responses to epidermal growth factor (EGF) were investigated in conscious sheep.
2. Ewes (n = 5 per group) received an i.v. saline infusion (150 mL/day) for days 1‐8, followed by either vehicle control, 15 μg/h EGF, 2mg/kg per day indomethacin or 15 μg/h EGF with 2 mg/kg per day indomethacin in 150 mL/day saline, i.v., over days 9‐12. All ewes subsequently received an i.v. saline infusion (150 mL/day) over days 13‐20.
3. Polydipsia, diuresis, transient natriuresis and reduced urine osmolality occurred during EGF treatment alone. There was no effect of EGF on fluid balance, plasma electrolyte or hormone concentrations, plasma osmolality or haematocrit or on the urinary excretion of potassium.
4. Simultaneous infusion of indomethacin with EGF attenuated (P>0.05) the stimulatory effects of EGF infusion alone on urine volume, water intake, natriuresis and urine osmolality.
5. We conclude that prostaglandins may be involved in the diuretic/natriuretic effects of EGF, but may not be the sole mechanism involved.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>9315369</pmid><doi>10.1111/j.1440-1681.1997.tb02112.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Clinical and experimental pharmacology & physiology, 1997-10, Vol.24 (9-10), p.680-685 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - pharmacology Appetite - drug effects Diuresis - drug effects epidermal growth factor Epidermal Growth Factor - blood Epidermal Growth Factor - pharmacology Female indomethacin Indomethacin - blood Indomethacin - pharmacology Kidney - drug effects Natriuresis - drug effects prostaglandins Prostaglandins - metabolism Sheep Urination - drug effects Water-Electrolyte Balance - drug effects |
| title | EFFECTS OF INDOMETHACIN ON EPIDERMAL GROWTH FACTOR-INDUCED RENAL RESPONSES IN SHEEP |
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