Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain
This study tested for sex differences in the effects of chronic nicotine administration and withdrawal on nicotinic acetylcholine receptor binding in brain. Rats received nicotine (0.6 mg kg , sc) or saline once daily for 15 days, and were sacrificed 1 or 20 days after termination of treatment. Satu...
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| Veröffentlicht in: | Life sciences (1973) 1997-08, Vol.61 (12), p.PL185-PL190 |
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| container_end_page | PL190 |
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| container_issue | 12 |
| container_start_page | PL185 |
| container_title | Life sciences (1973) |
| container_volume | 61 |
| creator | Koylu, Ersin Demirgören, Serdar London, Edythe D. Pöǧün, Sakire |
| description | This study tested for sex differences in the effects of chronic nicotine administration and withdrawal on nicotinic acetylcholine receptor binding in brain. Rats received nicotine (0.6
mg
kg
, sc) or saline once daily for 15 days, and were sacrificed 1 or 20 days after termination of treatment. Saturation studies of nAChR binding were performed using [
3H]cytisine as the radioligand in whole brain minus cerebellum taken from animals in the chronic treatment groups and from naive rats. Male but not female rats that received chronic nicotine had higher receptor densities than corresponding control groups; up-regulation of nAChR was not seen 20 days after withdrawal. Furthermore, in groups that showed no up-regulation (controls and rats withdrawn for 20 days), nAChR densities were higher in female rats than males. The findings underscore the importance of sex differences in pharmacological responses as well as in basal neurochemical parameters. |
| doi_str_mv | 10.1016/S0024-3205(97)00665-6 |
| format | Article |
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mg
kg
, sc) or saline once daily for 15 days, and were sacrificed 1 or 20 days after termination of treatment. Saturation studies of nAChR binding were performed using [
3H]cytisine as the radioligand in whole brain minus cerebellum taken from animals in the chronic treatment groups and from naive rats. Male but not female rats that received chronic nicotine had higher receptor densities than corresponding control groups; up-regulation of nAChR was not seen 20 days after withdrawal. Furthermore, in groups that showed no up-regulation (controls and rats withdrawn for 20 days), nAChR densities were higher in female rats than males. The findings underscore the importance of sex differences in pharmacological responses as well as in basal neurochemical parameters.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/S0024-3205(97)00665-6</identifier><identifier>PMID: 9315514</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Alkaloids - metabolism ; Animals ; Azocines ; Brain - drug effects ; Brain - metabolism ; cystine ; Drug Administration Schedule ; Female ; Kinetics ; Male ; nicotine ; Nicotine - pharmacology ; nicotine acetylcholine receptor ; Quinolizines ; Radioligand Assay ; Rats ; Rats, Sprague-Dawley ; Receptors, Nicotinic - biosynthesis ; Receptors, Nicotinic - metabolism ; Sex Characteristics ; sex differences ; Time Factors ; Up-Regulation ; withdrawal</subject><ispartof>Life sciences (1973), 1997-08, Vol.61 (12), p.PL185-PL190</ispartof><rights>1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-363989296bfeb2e355508a51af10c4800610b5377d68750d34fd132d48feffac3</citedby><cites>FETCH-LOGICAL-c441t-363989296bfeb2e355508a51af10c4800610b5377d68750d34fd132d48feffac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320597006656$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9315514$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koylu, Ersin</creatorcontrib><creatorcontrib>Demirgören, Serdar</creatorcontrib><creatorcontrib>London, Edythe D.</creatorcontrib><creatorcontrib>Pöǧün, Sakire</creatorcontrib><title>Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>This study tested for sex differences in the effects of chronic nicotine administration and withdrawal on nicotinic acetylcholine receptor binding in brain. Rats received nicotine (0.6
mg
kg
, sc) or saline once daily for 15 days, and were sacrificed 1 or 20 days after termination of treatment. Saturation studies of nAChR binding were performed using [
3H]cytisine as the radioligand in whole brain minus cerebellum taken from animals in the chronic treatment groups and from naive rats. Male but not female rats that received chronic nicotine had higher receptor densities than corresponding control groups; up-regulation of nAChR was not seen 20 days after withdrawal. Furthermore, in groups that showed no up-regulation (controls and rats withdrawn for 20 days), nAChR densities were higher in female rats than males. The findings underscore the importance of sex differences in pharmacological responses as well as in basal neurochemical parameters.</description><subject>Alkaloids - metabolism</subject><subject>Animals</subject><subject>Azocines</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>cystine</subject><subject>Drug Administration Schedule</subject><subject>Female</subject><subject>Kinetics</subject><subject>Male</subject><subject>nicotine</subject><subject>Nicotine - pharmacology</subject><subject>nicotine acetylcholine receptor</subject><subject>Quinolizines</subject><subject>Radioligand Assay</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Nicotinic - biosynthesis</subject><subject>Receptors, Nicotinic - metabolism</subject><subject>Sex Characteristics</subject><subject>sex differences</subject><subject>Time Factors</subject><subject>Up-Regulation</subject><subject>withdrawal</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1OwzAQhC0EKqXwCJVyQnAIrOPYSU4IVfxJlRAqnC3HWYNRGhc7QfTtSdqq1152DzOzq_kImVK4oUDF7QIgSWOWAL8qsmsAIXgsjsiY5lkRg2D0mIz3llNyFsI3AHCesREZFYxyTtMxeVvgX1RZY9BjozGyTdStYo-fXa1a65rImaix2rW2n5HS2K5r_eVq22DkUeOqdT4MKa_aqPTKNufkxKg64MVuT8jH48P77Dmevz69zO7nsU5T2sZMsCIvkkKUBssEGecccsWpMhR0mvd9KJScZVkl8oxDxVJTUZZUaW7QGKXZhFxu7668--kwtHJpg8a6Vg26Lsis7wiM0oNGKlLBIC96I98atXcheDRy5e1S-bWkIAfmcsNcDkBlkckNcyn63HT3oCuXWO1TO8i9frfVscfxa9HLoO1Au7I9wlZWzh748A-lGZA5</recordid><startdate>19970801</startdate><enddate>19970801</enddate><creator>Koylu, Ersin</creator><creator>Demirgören, Serdar</creator><creator>London, Edythe D.</creator><creator>Pöǧün, Sakire</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19970801</creationdate><title>Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain</title><author>Koylu, Ersin ; Demirgören, Serdar ; London, Edythe D. ; Pöǧün, Sakire</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-363989296bfeb2e355508a51af10c4800610b5377d68750d34fd132d48feffac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Alkaloids - metabolism</topic><topic>Animals</topic><topic>Azocines</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>cystine</topic><topic>Drug Administration Schedule</topic><topic>Female</topic><topic>Kinetics</topic><topic>Male</topic><topic>nicotine</topic><topic>Nicotine - pharmacology</topic><topic>nicotine acetylcholine receptor</topic><topic>Quinolizines</topic><topic>Radioligand Assay</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Nicotinic - biosynthesis</topic><topic>Receptors, Nicotinic - metabolism</topic><topic>Sex Characteristics</topic><topic>sex differences</topic><topic>Time Factors</topic><topic>Up-Regulation</topic><topic>withdrawal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koylu, Ersin</creatorcontrib><creatorcontrib>Demirgören, Serdar</creatorcontrib><creatorcontrib>London, Edythe D.</creatorcontrib><creatorcontrib>Pöǧün, Sakire</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koylu, Ersin</au><au>Demirgören, Serdar</au><au>London, Edythe D.</au><au>Pöǧün, Sakire</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1997-08-01</date><risdate>1997</risdate><volume>61</volume><issue>12</issue><spage>PL185</spage><epage>PL190</epage><pages>PL185-PL190</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>This study tested for sex differences in the effects of chronic nicotine administration and withdrawal on nicotinic acetylcholine receptor binding in brain. Rats received nicotine (0.6
mg
kg
, sc) or saline once daily for 15 days, and were sacrificed 1 or 20 days after termination of treatment. Saturation studies of nAChR binding were performed using [
3H]cytisine as the radioligand in whole brain minus cerebellum taken from animals in the chronic treatment groups and from naive rats. Male but not female rats that received chronic nicotine had higher receptor densities than corresponding control groups; up-regulation of nAChR was not seen 20 days after withdrawal. Furthermore, in groups that showed no up-regulation (controls and rats withdrawn for 20 days), nAChR densities were higher in female rats than males. The findings underscore the importance of sex differences in pharmacological responses as well as in basal neurochemical parameters.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>9315514</pmid><doi>10.1016/S0024-3205(97)00665-6</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1997-08, Vol.61 (12), p.PL185-PL190 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alkaloids - metabolism Animals Azocines Brain - drug effects Brain - metabolism cystine Drug Administration Schedule Female Kinetics Male nicotine Nicotine - pharmacology nicotine acetylcholine receptor Quinolizines Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Nicotinic - biosynthesis Receptors, Nicotinic - metabolism Sex Characteristics sex differences Time Factors Up-Regulation withdrawal |
| title | Sex difference in up-regulation of nicotinic acetylcholine receptors in rat brain |
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