Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag was identified that encodes Agouti-related protein, whose RNA is normally expressed in the hypothalamus and whose levels were increased eigh...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-10, Vol.278 (5335), p.135-138
Hauptverfasser:	Ollmann, Michael M., Wilson, Brent D., Yang, Ying-Kui, Kerns, Julie A., Chen, Yanru, Gantz, Ira, Barsh, Gregory S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Adrenal Glands - metabolism Amino Acid Sequence Anatomy Animals Biological and medical sciences Body Weight Buffer storage Causes of Classical genetics, quantitative genetics, hybrids Female Fundamental and applied biological sciences. Psychology Gene expression regulation Genetics of eukaryotes. Biological and molecular evolution Humans Hypothalamus Hypothalamus - metabolism Male Melanocortin receptors Melanocyte-Stimulating Hormones - antagonists & inhibitors Melanocyte-Stimulating Hormones - pharmacology Melanophores Melanophores - metabolism Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Obese Mice, Transgenic Molecular Sequence Data Neuropeptides Obesity Obesity - etiology Organophosphorus Compounds - pharmacology Physiological aspects Pigments Proteins Proteins - chemistry Proteins - genetics Proteins - pharmacology Proteins - physiology Receptor, Melanocortin, Type 3 Receptor, Melanocortin, Type 4 Receptors Receptors, Corticotropin - antagonists & inhibitors Receptors, Corticotropin - metabolism Receptors, Peptide - antagonists & inhibitors Receptors, Peptide - metabolism Recombinant Proteins - metabolism RNA RNA - genetics RNA - metabolism Signal Transduction Transgenic animals Vertebrata Xenopus
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