Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein
Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag was identified that encodes Agouti-related protein, whose RNA is normally expressed in the hypothalamus and whose levels were increased eigh...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1997-10, Vol.278 (5335), p.135-138 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 138 |
|---|---|
| container_issue | 5335 |
| container_start_page | 135 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 278 |
| creator | Ollmann, Michael M. Wilson, Brent D. Yang, Ying-Kui Kerns, Julie A. Chen, Yanru Gantz, Ira Barsh, Gregory S. |
| description | Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag was identified that encodes Agouti-related protein, whose RNA is normally expressed in the hypothalamus and whose levels were increased eightfold in ob/ob mice. Recombinant Agouti-related protein was a potent, selective antagonist of Mc3r and Mc4r, melanocortin receptor subtypes implicated in weight regulation. Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation. Thus, Agouti-related protein is a neuropeptide implicated in the normal control of body weight downstream of leptin signaling. |
| doi_str_mv | 10.1126/science.278.5335.135 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_79310015</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A20221499</galeid><jstor_id>2894525</jstor_id><sourcerecordid>A20221499</sourcerecordid><originalsourceid>FETCH-LOGICAL-c782t-5832a8d58dd8451f688a86ecf02b8c2672f48c531a92ec83584c948d4807ac563</originalsourceid><addsrcrecordid>eNqN082O0zAQAOAIgZay8AaLFCEEHDbFP3HiHEsFZaVC0QJ74WC5ziRyldoldhD79kxptaKogiqHyJ7PlmY8kyQXlIwpZcXrYCw4A2NWyrHgXIwpF_eSESWVyCpG-P1kRAgvMklK8TB5FMKKEIxV_Cw5qzilaEbJt4mLuvXOhnXqm3QKLva6Sz9Ap503vo_WpddgYBN9H1Jc3NjY-1S7erf44dPlbTpp_RBtdo2nItTpp95HsO5x8qDRXYAn-_958vXd2y_T99l8MbuaTuaZKSWLmZCcaVkLWdcyF7QppNSyANMQtpSGFSVrcmkEp7piYCQXMjdVLuscE9NGFPw8ebG7d9P77wOEqNY2GOgwBfBDUCVmSwgVCF_-G-a8xLrI8r9X0oIUWPMtfPYXXPmhd5iuYvgeZVWWFNHlDrW6A2Vd47HIpgUHWGvvoLG4PWGEMZpXFfLsCMevhrU1x_yrA48kws_Y6iEEdfX548l0cXMyfTM7lcrZ_IBeHqPGdx20oLAvposDnu-46X0IPTRq09u17m8VJWo7BWo_BQqnQG2nQGHV8djT_asMyzXUd4f2bY_x5_u4DkZ3Ta-dseGOMSko_d1YFzu2Ctj-f4SrXDDBfwFLwhON</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>213579771</pqid></control><display><type>article</type><title>Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein</title><source>MEDLINE</source><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><creator>Ollmann, Michael M. ; Wilson, Brent D. ; Yang, Ying-Kui ; Kerns, Julie A. ; Chen, Yanru ; Gantz, Ira ; Barsh, Gregory S.</creator><creatorcontrib>Ollmann, Michael M. ; Wilson, Brent D. ; Yang, Ying-Kui ; Kerns, Julie A. ; Chen, Yanru ; Gantz, Ira ; Barsh, Gregory S.</creatorcontrib><description>Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag was identified that encodes Agouti-related protein, whose RNA is normally expressed in the hypothalamus and whose levels were increased eightfold in ob/ob mice. Recombinant Agouti-related protein was a potent, selective antagonist of Mc3r and Mc4r, melanocortin receptor subtypes implicated in weight regulation. Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation. Thus, Agouti-related protein is a neuropeptide implicated in the normal control of body weight downstream of leptin signaling.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.278.5335.135</identifier><identifier>PMID: 9311920</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Adrenal glands ; Adrenal Glands - metabolism ; Amino Acid Sequence ; Anatomy ; Animals ; Biological and medical sciences ; Body Weight ; Buffer storage ; Causes of ; Classical genetics, quantitative genetics, hybrids ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression regulation ; Genetics of eukaryotes. Biological and molecular evolution ; Humans ; Hypothalamus ; Hypothalamus - metabolism ; Male ; Melanocortin receptors ; Melanocyte-Stimulating Hormones - antagonists & inhibitors ; Melanocyte-Stimulating Hormones - pharmacology ; Melanophores ; Melanophores - metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Inbred CBA ; Mice, Obese ; Mice, Transgenic ; Molecular Sequence Data ; Neuropeptides ; Obesity ; Obesity - etiology ; Organophosphorus Compounds - pharmacology ; Physiological aspects ; Pigments ; Proteins ; Proteins - chemistry ; Proteins - genetics ; Proteins - pharmacology ; Proteins - physiology ; Receptor, Melanocortin, Type 3 ; Receptor, Melanocortin, Type 4 ; Receptors ; Receptors, Corticotropin - antagonists & inhibitors ; Receptors, Corticotropin - metabolism ; Receptors, Peptide - antagonists & inhibitors ; Receptors, Peptide - metabolism ; Recombinant Proteins - metabolism ; RNA ; RNA - genetics ; RNA - metabolism ; Signal Transduction ; Transgenic animals ; Vertebrata ; Xenopus</subject><ispartof>Science (American Association for the Advancement of Science), 1997-10, Vol.278 (5335), p.135-138</ispartof><rights>Copyright 1997 American Association for the Advancement of Science</rights><rights>1997 INIST-CNRS</rights><rights>COPYRIGHT 1997 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1997 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Oct 3, 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c782t-5832a8d58dd8451f688a86ecf02b8c2672f48c531a92ec83584c948d4807ac563</citedby><cites>FETCH-LOGICAL-c782t-5832a8d58dd8451f688a86ecf02b8c2672f48c531a92ec83584c948d4807ac563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2894525$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2894525$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,2871,2872,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2851156$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9311920$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ollmann, Michael M.</creatorcontrib><creatorcontrib>Wilson, Brent D.</creatorcontrib><creatorcontrib>Yang, Ying-Kui</creatorcontrib><creatorcontrib>Kerns, Julie A.</creatorcontrib><creatorcontrib>Chen, Yanru</creatorcontrib><creatorcontrib>Gantz, Ira</creatorcontrib><creatorcontrib>Barsh, Gregory S.</creatorcontrib><title>Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag was identified that encodes Agouti-related protein, whose RNA is normally expressed in the hypothalamus and whose levels were increased eightfold in ob/ob mice. Recombinant Agouti-related protein was a potent, selective antagonist of Mc3r and Mc4r, melanocortin receptor subtypes implicated in weight regulation. Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation. Thus, Agouti-related protein is a neuropeptide implicated in the normal control of body weight downstream of leptin signaling.</description><subject>Adrenal glands</subject><subject>Adrenal Glands - metabolism</subject><subject>Amino Acid Sequence</subject><subject>Anatomy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Buffer storage</subject><subject>Causes of</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression regulation</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Hypothalamus - metabolism</subject><subject>Male</subject><subject>Melanocortin receptors</subject><subject>Melanocyte-Stimulating Hormones - antagonists & inhibitors</subject><subject>Melanocyte-Stimulating Hormones - pharmacology</subject><subject>Melanophores</subject><subject>Melanophores - metabolism</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred CBA</subject><subject>Mice, Obese</subject><subject>Mice, Transgenic</subject><subject>Molecular Sequence Data</subject><subject>Neuropeptides</subject><subject>Obesity</subject><subject>Obesity - etiology</subject><subject>Organophosphorus Compounds - pharmacology</subject><subject>Physiological aspects</subject><subject>Pigments</subject><subject>Proteins</subject><subject>Proteins - chemistry</subject><subject>Proteins - genetics</subject><subject>Proteins - pharmacology</subject><subject>Proteins - physiology</subject><subject>Receptor, Melanocortin, Type 3</subject><subject>Receptor, Melanocortin, Type 4</subject><subject>Receptors</subject><subject>Receptors, Corticotropin - antagonists & inhibitors</subject><subject>Receptors, Corticotropin - metabolism</subject><subject>Receptors, Peptide - antagonists & inhibitors</subject><subject>Receptors, Peptide - metabolism</subject><subject>Recombinant Proteins - metabolism</subject><subject>RNA</subject><subject>RNA - genetics</subject><subject>RNA - metabolism</subject><subject>Signal Transduction</subject><subject>Transgenic animals</subject><subject>Vertebrata</subject><subject>Xenopus</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN082O0zAQAOAIgZay8AaLFCEEHDbFP3HiHEsFZaVC0QJ74WC5ziRyldoldhD79kxptaKogiqHyJ7PlmY8kyQXlIwpZcXrYCw4A2NWyrHgXIwpF_eSESWVyCpG-P1kRAgvMklK8TB5FMKKEIxV_Cw5qzilaEbJt4mLuvXOhnXqm3QKLva6Sz9Ap503vo_WpddgYBN9H1Jc3NjY-1S7erf44dPlbTpp_RBtdo2nItTpp95HsO5x8qDRXYAn-_958vXd2y_T99l8MbuaTuaZKSWLmZCcaVkLWdcyF7QppNSyANMQtpSGFSVrcmkEp7piYCQXMjdVLuscE9NGFPw8ebG7d9P77wOEqNY2GOgwBfBDUCVmSwgVCF_-G-a8xLrI8r9X0oIUWPMtfPYXXPmhd5iuYvgeZVWWFNHlDrW6A2Vd47HIpgUHWGvvoLG4PWGEMZpXFfLsCMevhrU1x_yrA48kws_Y6iEEdfX548l0cXMyfTM7lcrZ_IBeHqPGdx20oLAvposDnu-46X0IPTRq09u17m8VJWo7BWo_BQqnQG2nQGHV8djT_asMyzXUd4f2bY_x5_u4DkZ3Ta-dseGOMSko_d1YFzu2Ctj-f4SrXDDBfwFLwhON</recordid><startdate>19971003</startdate><enddate>19971003</enddate><creator>Ollmann, Michael M.</creator><creator>Wilson, Brent D.</creator><creator>Yang, Ying-Kui</creator><creator>Kerns, Julie A.</creator><creator>Chen, Yanru</creator><creator>Gantz, Ira</creator><creator>Barsh, Gregory S.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>0-V</scope><scope>3V.</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88B</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CJNVE</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9-</scope><scope>K9.</scope><scope>KB.</scope><scope>KR7</scope><scope>L6V</scope><scope>L7M</scope><scope>LK8</scope><scope>L~C</scope><scope>L~D</scope><scope>M0K</scope><scope>M0P</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>MBDVC</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEDU</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>R05</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19971003</creationdate><title>Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein</title><author>Ollmann, Michael M. ; Wilson, Brent D. ; Yang, Ying-Kui ; Kerns, Julie A. ; Chen, Yanru ; Gantz, Ira ; Barsh, Gregory S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c782t-5832a8d58dd8451f688a86ecf02b8c2672f48c531a92ec83584c948d4807ac563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adrenal glands</topic><topic>Adrenal Glands - metabolism</topic><topic>Amino Acid Sequence</topic><topic>Anatomy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Buffer storage</topic><topic>Causes of</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression regulation</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Hypothalamus - metabolism</topic><topic>Male</topic><topic>Melanocortin receptors</topic><topic>Melanocyte-Stimulating Hormones - antagonists & inhibitors</topic><topic>Melanocyte-Stimulating Hormones - pharmacology</topic><topic>Melanophores</topic><topic>Melanophores - metabolism</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred CBA</topic><topic>Mice, Obese</topic><topic>Mice, Transgenic</topic><topic>Molecular Sequence Data</topic><topic>Neuropeptides</topic><topic>Obesity</topic><topic>Obesity - etiology</topic><topic>Organophosphorus Compounds - pharmacology</topic><topic>Physiological aspects</topic><topic>Pigments</topic><topic>Proteins</topic><topic>Proteins - chemistry</topic><topic>Proteins - genetics</topic><topic>Proteins - pharmacology</topic><topic>Proteins - physiology</topic><topic>Receptor, Melanocortin, Type 3</topic><topic>Receptor, Melanocortin, Type 4</topic><topic>Receptors</topic><topic>Receptors, Corticotropin - antagonists & inhibitors</topic><topic>Receptors, Corticotropin - metabolism</topic><topic>Receptors, Peptide - antagonists & inhibitors</topic><topic>Receptors, Peptide - metabolism</topic><topic>Recombinant Proteins - metabolism</topic><topic>RNA</topic><topic>RNA - genetics</topic><topic>RNA - metabolism</topic><topic>Signal Transduction</topic><topic>Transgenic animals</topic><topic>Vertebrata</topic><topic>Xenopus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ollmann, Michael M.</creatorcontrib><creatorcontrib>Wilson, Brent D.</creatorcontrib><creatorcontrib>Yang, Ying-Kui</creatorcontrib><creatorcontrib>Kerns, Julie A.</creatorcontrib><creatorcontrib>Chen, Yanru</creatorcontrib><creatorcontrib>Gantz, Ira</creatorcontrib><creatorcontrib>Barsh, Gregory S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Education Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Education Collection</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Civil Engineering Abstracts</collection><collection>ProQuest Engineering Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>ProQuest Biological Science Collection</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Agricultural Science Database</collection><collection>Education Database</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Research Library (Corporate)</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Education</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>University of Michigan</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ollmann, Michael M.</au><au>Wilson, Brent D.</au><au>Yang, Ying-Kui</au><au>Kerns, Julie A.</au><au>Chen, Yanru</au><au>Gantz, Ira</au><au>Barsh, Gregory S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1997-10-03</date><risdate>1997</risdate><volume>278</volume><issue>5335</issue><spage>135</spage><epage>138</epage><pages>135-138</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Expression of Agouti protein is normally limited to the skin where it affects pigmentation, but ubiquitous expression causes obesity. An expressed sequence tag was identified that encodes Agouti-related protein, whose RNA is normally expressed in the hypothalamus and whose levels were increased eightfold in ob/ob mice. Recombinant Agouti-related protein was a potent, selective antagonist of Mc3r and Mc4r, melanocortin receptor subtypes implicated in weight regulation. Ubiquitous expression of human AGRP complementary DNA in transgenic mice caused obesity without altering pigmentation. Thus, Agouti-related protein is a neuropeptide implicated in the normal control of body weight downstream of leptin signaling.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>9311920</pmid><doi>10.1126/science.278.5335.135</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1997-10, Vol.278 (5335), p.135-138 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79310015 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Adrenal glands Adrenal Glands - metabolism Amino Acid Sequence Anatomy Animals Biological and medical sciences Body Weight Buffer storage Causes of Classical genetics, quantitative genetics, hybrids Female Fundamental and applied biological sciences. Psychology Gene expression regulation Genetics of eukaryotes. Biological and molecular evolution Humans Hypothalamus Hypothalamus - metabolism Male Melanocortin receptors Melanocyte-Stimulating Hormones - antagonists & inhibitors Melanocyte-Stimulating Hormones - pharmacology Melanophores Melanophores - metabolism Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Obese Mice, Transgenic Molecular Sequence Data Neuropeptides Obesity Obesity - etiology Organophosphorus Compounds - pharmacology Physiological aspects Pigments Proteins Proteins - chemistry Proteins - genetics Proteins - pharmacology Proteins - physiology Receptor, Melanocortin, Type 3 Receptor, Melanocortin, Type 4 Receptors Receptors, Corticotropin - antagonists & inhibitors Receptors, Corticotropin - metabolism Receptors, Peptide - antagonists & inhibitors Receptors, Peptide - metabolism Recombinant Proteins - metabolism RNA RNA - genetics RNA - metabolism Signal Transduction Transgenic animals Vertebrata Xenopus |
| title | Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T01%3A03%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antagonism%20of%20Central%20Melanocortin%20Receptors%20in%20Vitro%20and%20in%20Vivo%20by%20Agouti-Related%20Protein&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Ollmann,%20Michael%20M.&rft.date=1997-10-03&rft.volume=278&rft.issue=5335&rft.spage=135&rft.epage=138&rft.pages=135-138&rft.issn=0036-8075&rft.eissn=1095-9203&rft.coden=SCIEAS&rft_id=info:doi/10.1126/science.278.5335.135&rft_dat=%3Cgale_proqu%3EA20221499%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=213579771&rft_id=info:pmid/9311920&rft_galeid=A20221499&rft_jstor_id=2894525&rfr_iscdi=true |