Pharmacological activity of PF-904 in guinea-pig in vivo, and on human bronchus and neutrophils in vitro

The effects of PF-904 (4-amino-1-ethyl-6-methylpyrazino[2,3-c][1,2,6]thiadiazine 2,2-dioxide), a pyrazinothiadiazine derivative, were examined in guinea-pig airways in vivo, in human isolated bronchus and human polymorphonuclear leukocytes. PF-904 (12.5–200 mg kg −1, intraduodenal) reduced bronchoco...

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Veröffentlicht in:	European journal of pharmacology 1997-08, Vol.333 (1), p.69-78
Hauptverfasser:	Cortijo, Julio, Martı́-Cabrera, Miguel, Berto, Luisa, Antón, Francisca, Carrasco, Emilio, Grau, Manuel, Morcillo, Esteban J
Format:	Artikel
Sprache:	eng
Schlagworte:	Airway, guinea-pig Airway, hyperreactivity Animals Anti-Asthmatic Agents - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Biological and medical sciences Bronchi - drug effects Bronchi - metabolism Bronchial Hyperreactivity - physiopathology Bronchial Hyperreactivity - prevention & control Bronchial Provocation Tests Bronchodilator Agents - pharmacology Bronchus, human, isolated Capillary Permeability - drug effects Eosinophil infiltration, airway Guinea Pigs Humans In Vitro Techniques Male Medical sciences Microvascular leakage, airway N-Formylmethionine Leucyl-Phenylalanine - pharmacology Neutrophils - drug effects Neutrophils - metabolism Neutrophils, human PF-904 Pharmacology. Drug treatments Phosphodiesterase activity Phosphodiesterase Inhibitors - pharmacology Platelet Activating Factor - pharmacology Pyrazines - pharmacology Respiratory system Superoxide anion generation Superoxides - metabolism Thiadiazines - pharmacology
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