Responses to NMDA in cultured hippocampal neurons from trisomy 16 embryonic mice

The trisomy 16 (Ts16) mouse is regarded as a model of human trisomy 21 (Ts21), or Down syndrome. The ionic current evoked by the glutamate receptor agonist N-methyl- d-aspartate (NMDA) was investigated in cultured hippocampal neurons from embryonic Ts16 and control diploid mice. In both Ts16 and con...

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Veröffentlicht in:	Neuroscience letters 1997-09, Vol.232 (3), p.131-134
Hauptverfasser:	Siarey, R.J, Coan, E.J, Rapoport, S.I, Galdzicki, Z
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Chromosome aberrations Disease Models, Animal Down syndrome Down Syndrome - physiopathology Evoked Potentials - drug effects Excitatory Amino Acid Agonists - pharmacology Glutamate Hippocampus Hippocampus - drug effects Medical genetics Medical sciences Mice N-Methyl- d-aspartate N-Methylaspartate - pharmacology Neurons - drug effects Patch-Clamp Techniques Trisomy 16 Whole-cell patch-clamp
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