Selective improvement of aged rat short-term spatial memory by 3,4-diaminopyridine
Young (10 month) and old (28 month) Fischer 344 rats were injected (IP) with 3,4-diaminopyridine (3,4-DAP) or saline 10 minutes before training on two tests of spatial memory (the Barnes circular platform and the radial 8-arm maze). This agent has been found to block potassium channels in neurons, t...
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| Veröffentlicht in: | Neurobiology of aging 1989-07, Vol.10 (4), p.337-341 |
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| creator | Barnes, C.A. Eppich, C. Rao, G. |
| description | Young (10 month) and old (28 month) Fischer 344 rats were injected (IP) with 3,4-diaminopyridine (3,4-DAP) or saline 10 minutes before training on two tests of spatial memory (the Barnes circular platform and the radial 8-arm maze). This agent has been found to block potassium channels in neurons, thereby increasing calcium influx, prolonging the action potential, and leading to increased transmitter release. The circular platform task assessed the drug's effect on spatial reference memory over 24 hour intertrial intervals, and the radial maze assessed its effect on short-term working memory within a 5 minute test session. 3,4-DAP was found to selectively improve memory performance of the old animals, and, within that age group, only improved performance on the short-term memory task. 3,4-DAP may therefore be effective for only a restricted set of age-related memory problems. |
| doi_str_mv | 10.1016/0197-4580(89)90045-6 |
| format | Article |
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This agent has been found to block potassium channels in neurons, thereby increasing calcium influx, prolonging the action potential, and leading to increased transmitter release. The circular platform task assessed the drug's effect on spatial reference memory over 24 hour intertrial intervals, and the radial maze assessed its effect on short-term working memory within a 5 minute test session. 3,4-DAP was found to selectively improve memory performance of the old animals, and, within that age group, only improved performance on the short-term memory task. 3,4-DAP may therefore be effective for only a restricted set of age-related memory problems.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/0197-4580(89)90045-6</identifier><identifier>PMID: 2554167</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>3,4-Diaminopyridine ; 4-Aminopyridine - analogs & derivatives ; 4-Aminopyridine - pharmacokinetics ; Aging ; Amifampridine ; Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Male ; Memory deficits ; Memory, Short-Term - drug effects ; Miscellaneous ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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This agent has been found to block potassium channels in neurons, thereby increasing calcium influx, prolonging the action potential, and leading to increased transmitter release. The circular platform task assessed the drug's effect on spatial reference memory over 24 hour intertrial intervals, and the radial maze assessed its effect on short-term working memory within a 5 minute test session. 3,4-DAP was found to selectively improve memory performance of the old animals, and, within that age group, only improved performance on the short-term memory task. 3,4-DAP may therefore be effective for only a restricted set of age-related memory problems.</description><subject>3,4-Diaminopyridine</subject><subject>4-Aminopyridine - analogs & derivatives</subject><subject>4-Aminopyridine - pharmacokinetics</subject><subject>Aging</subject><subject>Amifampridine</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Memory deficits</subject><subject>Memory, Short-Term - drug effects</subject><subject>Miscellaneous</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Space Perception</subject><subject>Spatial memory</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVp2G6S_oMWdGlIIE40tmRJl0AI-YJAIG3OQpZHrYplbyXvwv77eLvL9tac5vA-8zI8Q8gXYBfAoL5koGXBhWKnSp9pxrgo6g9kDkKoAriWH8l8j3wihzn_ZoxJLusZmZVCcKjlnLx8xw7dGFZIQ1ykYYUR-5EOntqf2NJkR5p_DWksRkyR5oUdg-1oxDikNW3WtDrnRRtsDP2wWKfQhh6PyYG3XcbPu3lEXu9uf9w8FE_P948310-F46DGwgpslSt50ypfN5pb5x2XwnldshLBcsAGfOWBK6wYZ96C43WthRdNA0JVR-Rk2zud_WeJeTQxZIddZ3scltlIXTEpGXsXBFFNvUpOIN-CLg05J_RmkUK0aW2AmY1zsxFqNkKN0uavc1NPa193_csmYrtf2kme8m-73GZnO59s70L-161FBVVZTtzVlsPJ2ipgMtkF7B22IU0_Mu0Q_n_IG5-tnX4</recordid><startdate>19890701</startdate><enddate>19890701</enddate><creator>Barnes, C.A.</creator><creator>Eppich, C.</creator><creator>Rao, G.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19890701</creationdate><title>Selective improvement of aged rat short-term spatial memory by 3,4-diaminopyridine</title><author>Barnes, C.A. ; Eppich, C. ; Rao, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-a5ed8c24bd8f6b94acfc475cf9202e1a41eb1f3f148e3040fa1c46695f5bb1583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>3,4-Diaminopyridine</topic><topic>4-Aminopyridine - analogs & derivatives</topic><topic>4-Aminopyridine - pharmacokinetics</topic><topic>Aging</topic><topic>Amifampridine</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Memory deficits</topic><topic>Memory, Short-Term - drug effects</topic><topic>Miscellaneous</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Space Perception</topic><topic>Spatial memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barnes, C.A.</creatorcontrib><creatorcontrib>Eppich, C.</creatorcontrib><creatorcontrib>Rao, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barnes, C.A.</au><au>Eppich, C.</au><au>Rao, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective improvement of aged rat short-term spatial memory by 3,4-diaminopyridine</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1989-07-01</date><risdate>1989</risdate><volume>10</volume><issue>4</issue><spage>337</spage><epage>341</epage><pages>337-341</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Young (10 month) and old (28 month) Fischer 344 rats were injected (IP) with 3,4-diaminopyridine (3,4-DAP) or saline 10 minutes before training on two tests of spatial memory (the Barnes circular platform and the radial 8-arm maze). This agent has been found to block potassium channels in neurons, thereby increasing calcium influx, prolonging the action potential, and leading to increased transmitter release. The circular platform task assessed the drug's effect on spatial reference memory over 24 hour intertrial intervals, and the radial maze assessed its effect on short-term working memory within a 5 minute test session. 3,4-DAP was found to selectively improve memory performance of the old animals, and, within that age group, only improved performance on the short-term memory task. 3,4-DAP may therefore be effective for only a restricted set of age-related memory problems.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>2554167</pmid><doi>10.1016/0197-4580(89)90045-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neurobiology of aging, 1989-07, Vol.10 (4), p.337-341 |
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| subjects | 3,4-Diaminopyridine 4-Aminopyridine - analogs & derivatives 4-Aminopyridine - pharmacokinetics Aging Amifampridine Animals Behavioral psychophysiology Biological and medical sciences Fundamental and applied biological sciences. Psychology Male Memory deficits Memory, Short-Term - drug effects Miscellaneous Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Inbred F344 Space Perception Spatial memory |
| title | Selective improvement of aged rat short-term spatial memory by 3,4-diaminopyridine |
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