Characterization of the calcium channel state transitions induced by the enantiomers of the 1,4-dihydropyridine Sandoz 202 791 in neonatal rat heart cells. A nonmodulated receptor model

The actions of the optical enantiomers of Sandoz 202 791 were studied in barium inward currents recorded from single cultured neonatal rat ventricular heart cells, using the whole-cell configuration of the patch clamp technique. The enantiomers were applied by bath perfusion or rapidly by the techni...

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Veröffentlicht in:	Pflügers Archiv 1989-09, Vol.414 (6), p.690-700
Hauptverfasser:	Hering, S, Kleppisch, T, Timin, E N, Bodewei, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Barium - pharmacology Barium Compounds Calcium Channel Agonists - pharmacology Calcium Channel Blockers - pharmacology Calcium Channels - drug effects Cells, Cultured Chlorides Dihydropyridines - pharmacology Heart - drug effects Ion Channel Gating - drug effects Membrane Potentials - drug effects Models, Biological Rats Rats, Inbred Strains Stereoisomerism
Online-Zugang:	Volltext
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