Activity-wheel stress and serotonergic hypersensitivity in rats
Adult male Wistar rats were subjected to activity wheel stress: unlimited access to an activity wheel for up to twelve days and food for 30 to 60 min each day. Each treated rat was paired with a control, the latter being housed in home cages and given sufficient food to maintain a weight similar to...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 1989-06, Vol.33 (2), p.349-353 |
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| container_end_page | 353 |
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| container_title | Pharmacology, biochemistry and behavior |
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| creator | Mayeda, A.R. Simon, J.R. Hingtgen, J.N. Hofstetter, J.R. Aprison, M.H. |
| description | Adult male Wistar rats were subjected to activity wheel stress: unlimited access to an activity wheel for up to twelve days and food for 30 to 60 min each day. Each treated rat was paired with a control, the latter being housed in home cages and given sufficient food to maintain a weight similar to the stressed partner. All rats were previously trained on a variable interval schedule for milk reinforcement. When the activity of the stressed rat increased rapidly then decreased suddenly, the pair was decapitated for biochemical analysis. Levels of the serotonin metabolite, 5-hydroxyindoleacetic acid, decreased by 50%, and the B
max for ketanserin binding increased by 19% in frontal cortical homogenates from the stressed rats when compared to controls. These data support the concept that stress increases the sensitivity of central serotonin receptors. |
| doi_str_mv | 10.1016/0091-3057(89)90512-1 |
| format | Article |
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max for ketanserin binding increased by 19% in frontal cortical homogenates from the stressed rats when compared to controls. These data support the concept that stress increases the sensitivity of central serotonin receptors.</description><subject>5-HT 2 receptor</subject><subject>5-Hydroxyindoleacetic acid</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Cerebral Cortex - metabolism</subject><subject>Chronic Disease</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydroxyindoleacetic Acid - analysis</subject><subject>Ketanserin - metabolism</subject><subject>Ketanserin binding</subject><subject>Motor Activity</subject><subject>Physical Exertion</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Serotonin - analysis</subject><subject>Serotonergic hypersensitivity</subject><subject>Serotonin</subject><subject>Serotonin - metabolism</subject><subject>Serotonin - physiology</subject><subject>Stress</subject><subject>Stress, Physiological - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFq3DAQhkVJSDdp3qAFH0JpDm4kS_JYl5SwJGkg0Et6FrI0ThS89lbj3bJvXzte9ticZmC--fn5GPss-HfBRXnFuRG55Bq-VebScC2KXHxgC1GBzLUAOGKLA_KRnRK9cs5VUcIJOykUGC71gv248UPcxmGX_31BbDMaEhJlrgsZYeqHvsP0HH32sltjIuwozngWuyy5gT6x48a1hOf7ecZ-390-LX_mj7_uH5Y3j7lXAoa8qSvHdagKM1VStfBOF1CUtQjAxy7jilqZGgp0QVdQgWuMB1UDNjIElGfs65y7Tv2fDdJgV5E8tq3rsN-QBSO5MiDeBYWWJSitRlDNoE89UcLGrlNcubSzgttJsJ2q2smerYx9E2yn_C_7_E29wnB42hsd7xf7uyPv2ia5zkc6YGUphAQ5YtczhqO0bcRkyUfsPIaY0A829PH_Pf4BEUyWcg</recordid><startdate>19890601</startdate><enddate>19890601</enddate><creator>Mayeda, A.R.</creator><creator>Simon, J.R.</creator><creator>Hingtgen, J.N.</creator><creator>Hofstetter, J.R.</creator><creator>Aprison, M.H.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19890601</creationdate><title>Activity-wheel stress and serotonergic hypersensitivity in rats</title><author>Mayeda, A.R. ; Simon, J.R. ; Hingtgen, J.N. ; Hofstetter, J.R. ; Aprison, M.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-fb8a05d82900914b1ca52726b1d70479726e549b72ead58787af9c74b7ef3dde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>5-HT 2 receptor</topic><topic>5-Hydroxyindoleacetic acid</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central neurotransmission. 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| ispartof | Pharmacology, biochemistry and behavior, 1989-06, Vol.33 (2), p.349-353 |
| issn | 0091-3057 1873-5177 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 5-HT 2 receptor 5-Hydroxyindoleacetic acid Animals Biological and medical sciences Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebral Cortex - metabolism Chronic Disease Fundamental and applied biological sciences. Psychology Hydroxyindoleacetic Acid - analysis Ketanserin - metabolism Ketanserin binding Motor Activity Physical Exertion Rats Rats, Inbred Strains Receptors, Serotonin - analysis Serotonergic hypersensitivity Serotonin Serotonin - metabolism Serotonin - physiology Stress Stress, Physiological - metabolism Vertebrates: nervous system and sense organs |
| title | Activity-wheel stress and serotonergic hypersensitivity in rats |
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