Expression of oligodendrocytic mRNAs in glial tumors : Changes associated with tumor grade and extent of neoplastic infiltration

We examined the expression of glial- and neuronal-specific mRNAs within human gliomas using in situ hybridization. We found that low-grade astrocytomas contained a high number of proteolipid protein (PLP) mRNA-positive cells and that the number of PLP-stained cells decreased markedly with increasing...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-09, Vol.57 (18), p.4098-4104
Hauptverfasser:	LANDRY, C. F, VERITY, M. A, CHERMAN, L, KASHIMA, T, BLACK, K, YATES, A, CAMPAGNONI, A. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Astrocytoma - genetics Biological and medical sciences Brain Neoplasms - genetics Gene Expression Regulation, Neoplastic Glial Fibrillary Acidic Protein - genetics Glioma - genetics Humans In Situ Hybridization Keratins - genetics Medical sciences Myelin Basic Protein - genetics Myelin Proteolipid Protein - genetics Neurofilament Proteins - genetics Neuroglia - physiology Neurology Neurons - physiology Oligodendroglia - physiology Oligodendroglioma - genetics RNA, Messenger - genetics RNA, Neoplasm - genetics Tumors of the nervous system. Phacomatoses Vimentin - genetics
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