Protein phosphorylation and compartments of cyclic AMP in the control of cardiac contraction
The roles of cyclic AMP, cyclic AMP-dependent protein kinase and the phosphorylation of specific proteins in the regulation of cardiac contractility are briefly reviewed. Criteria for determining whether changes in cyclic AMP and protein phosphorylation are involved in a physiological response are d...
Gespeichert in:
| Veröffentlicht in: | Molecular and cellular biochemistry 1989-09, Vol.89 (2), p.175-179 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 179 |
|---|---|
| container_issue | 2 |
| container_start_page | 175 |
| container_title | Molecular and cellular biochemistry |
| container_volume | 89 |
| creator | Murray, K J Reeves, M L England, P J |
| description | The roles of cyclic AMP, cyclic AMP-dependent protein kinase and the phosphorylation of specific proteins in the regulation of cardiac contractility are briefly reviewed. Criteria for determining whether changes in cyclic AMP and protein phosphorylation are involved in a physiological response are discussed. Although cyclic AMP-dependent phosphorylation of the voltage-operated Ca2+ channel, phospholamban, troponin-I and C-protein have all been implicated in the response of the heart to inotropic agents which elevate cyclic AMP, none of these phosphorylations satisfy all of the criteria completely. Evidence is presented that there are compartments of cyclic AMP in heart which are coupled to different functional responses. |
| doi_str_mv | 10.1007/bf00220772 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79302020</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79302020</sourcerecordid><originalsourceid>FETCH-LOGICAL-c379t-d8f082bd3f938b4c84cce56c9400e7269efdd125c30d495a75356d83b22e3ea23</originalsourceid><addsrcrecordid>eNqFkDFPwzAQRi0EKqWwsCNlYkAKnH1xHY-looBURAfYkCLHdtSgJA62O_Tfk9LCik6nk-7efcMj5JLCLQUQd2UFwBgIwY7ImHKBaSapPCZjQIA0p0KckrMQPgEGnNIRGTHOM8pwTD5W3kVbd0m_dmFov21UrF2XqM4k2rW98rG1XQyJqxK91U2tk9nLKhk-4toORBe9a36Oypta6f1K6V3IOTmpVBPsxWFOyPvi4W3-lC5fH5_ns2WqUciYmryCnJUGK4l5mek809ryqZYZgBVsKm1lDGVcI5hMciU48qnJsWTMolUMJ-R6n9t797WxIRZtHbRtGtVZtwmFkAhsqH9BylFmOAickJs9qL0Lwduq6H3dKr8tKBQ758X94tf5AF8dUjdla80fepCM30WEe_s</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15394357</pqid></control><display><type>article</type><title>Protein phosphorylation and compartments of cyclic AMP in the control of cardiac contraction</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Murray, K J ; Reeves, M L ; England, P J</creator><creatorcontrib>Murray, K J ; Reeves, M L ; England, P J</creatorcontrib><description>The roles of cyclic AMP, cyclic AMP-dependent protein kinase and the phosphorylation of specific proteins in the regulation of cardiac contractility are briefly reviewed. Criteria for determining whether changes in cyclic AMP and protein phosphorylation are involved in a physiological response are discussed. Although cyclic AMP-dependent phosphorylation of the voltage-operated Ca2+ channel, phospholamban, troponin-I and C-protein have all been implicated in the response of the heart to inotropic agents which elevate cyclic AMP, none of these phosphorylations satisfy all of the criteria completely. Evidence is presented that there are compartments of cyclic AMP in heart which are coupled to different functional responses.</description><identifier>ISSN: 0300-8177</identifier><identifier>EISSN: 1573-4919</identifier><identifier>DOI: 10.1007/bf00220772</identifier><identifier>PMID: 2554123</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Animals ; Calcium Channels - metabolism ; Calcium-Binding Proteins - metabolism ; cardiac muscle ; Carrier Proteins ; cyclic AMP ; Cyclic AMP - physiology ; Muscle Proteins - metabolism ; Myocardial Contraction - physiology ; Myocardium - metabolism ; Phosphorylation ; Protein Kinases - metabolism ; Proteins - metabolism ; Troponin - metabolism ; Troponin I</subject><ispartof>Molecular and cellular biochemistry, 1989-09, Vol.89 (2), p.175-179</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-d8f082bd3f938b4c84cce56c9400e7269efdd125c30d495a75356d83b22e3ea23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2554123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murray, K J</creatorcontrib><creatorcontrib>Reeves, M L</creatorcontrib><creatorcontrib>England, P J</creatorcontrib><title>Protein phosphorylation and compartments of cyclic AMP in the control of cardiac contraction</title><title>Molecular and cellular biochemistry</title><addtitle>Mol Cell Biochem</addtitle><description>The roles of cyclic AMP, cyclic AMP-dependent protein kinase and the phosphorylation of specific proteins in the regulation of cardiac contractility are briefly reviewed. Criteria for determining whether changes in cyclic AMP and protein phosphorylation are involved in a physiological response are discussed. Although cyclic AMP-dependent phosphorylation of the voltage-operated Ca2+ channel, phospholamban, troponin-I and C-protein have all been implicated in the response of the heart to inotropic agents which elevate cyclic AMP, none of these phosphorylations satisfy all of the criteria completely. Evidence is presented that there are compartments of cyclic AMP in heart which are coupled to different functional responses.</description><subject>Animals</subject><subject>Calcium Channels - metabolism</subject><subject>Calcium-Binding Proteins - metabolism</subject><subject>cardiac muscle</subject><subject>Carrier Proteins</subject><subject>cyclic AMP</subject><subject>Cyclic AMP - physiology</subject><subject>Muscle Proteins - metabolism</subject><subject>Myocardial Contraction - physiology</subject><subject>Myocardium - metabolism</subject><subject>Phosphorylation</subject><subject>Protein Kinases - metabolism</subject><subject>Proteins - metabolism</subject><subject>Troponin - metabolism</subject><subject>Troponin I</subject><issn>0300-8177</issn><issn>1573-4919</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFPwzAQRi0EKqWwsCNlYkAKnH1xHY-looBURAfYkCLHdtSgJA62O_Tfk9LCik6nk-7efcMj5JLCLQUQd2UFwBgIwY7ImHKBaSapPCZjQIA0p0KckrMQPgEGnNIRGTHOM8pwTD5W3kVbd0m_dmFov21UrF2XqM4k2rW98rG1XQyJqxK91U2tk9nLKhk-4toORBe9a36Oypta6f1K6V3IOTmpVBPsxWFOyPvi4W3-lC5fH5_ns2WqUciYmryCnJUGK4l5mek809ryqZYZgBVsKm1lDGVcI5hMciU48qnJsWTMolUMJ-R6n9t797WxIRZtHbRtGtVZtwmFkAhsqH9BylFmOAickJs9qL0Lwduq6H3dKr8tKBQ758X94tf5AF8dUjdla80fepCM30WEe_s</recordid><startdate>19890907</startdate><enddate>19890907</enddate><creator>Murray, K J</creator><creator>Reeves, M L</creator><creator>England, P J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19890907</creationdate><title>Protein phosphorylation and compartments of cyclic AMP in the control of cardiac contraction</title><author>Murray, K J ; Reeves, M L ; England, P J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-d8f082bd3f938b4c84cce56c9400e7269efdd125c30d495a75356d83b22e3ea23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Calcium Channels - metabolism</topic><topic>Calcium-Binding Proteins - metabolism</topic><topic>cardiac muscle</topic><topic>Carrier Proteins</topic><topic>cyclic AMP</topic><topic>Cyclic AMP - physiology</topic><topic>Muscle Proteins - metabolism</topic><topic>Myocardial Contraction - physiology</topic><topic>Myocardium - metabolism</topic><topic>Phosphorylation</topic><topic>Protein Kinases - metabolism</topic><topic>Proteins - metabolism</topic><topic>Troponin - metabolism</topic><topic>Troponin I</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murray, K J</creatorcontrib><creatorcontrib>Reeves, M L</creatorcontrib><creatorcontrib>England, P J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular and cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murray, K J</au><au>Reeves, M L</au><au>England, P J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein phosphorylation and compartments of cyclic AMP in the control of cardiac contraction</atitle><jtitle>Molecular and cellular biochemistry</jtitle><addtitle>Mol Cell Biochem</addtitle><date>1989-09-07</date><risdate>1989</risdate><volume>89</volume><issue>2</issue><spage>175</spage><epage>179</epage><pages>175-179</pages><issn>0300-8177</issn><eissn>1573-4919</eissn><abstract>The roles of cyclic AMP, cyclic AMP-dependent protein kinase and the phosphorylation of specific proteins in the regulation of cardiac contractility are briefly reviewed. Criteria for determining whether changes in cyclic AMP and protein phosphorylation are involved in a physiological response are discussed. Although cyclic AMP-dependent phosphorylation of the voltage-operated Ca2+ channel, phospholamban, troponin-I and C-protein have all been implicated in the response of the heart to inotropic agents which elevate cyclic AMP, none of these phosphorylations satisfy all of the criteria completely. Evidence is presented that there are compartments of cyclic AMP in heart which are coupled to different functional responses.</abstract><cop>Netherlands</cop><pmid>2554123</pmid><doi>10.1007/bf00220772</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8177 |
| ispartof | Molecular and cellular biochemistry, 1989-09, Vol.89 (2), p.175-179 |
| issn | 0300-8177 1573-4919 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79302020 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Calcium Channels - metabolism Calcium-Binding Proteins - metabolism cardiac muscle Carrier Proteins cyclic AMP Cyclic AMP - physiology Muscle Proteins - metabolism Myocardial Contraction - physiology Myocardium - metabolism Phosphorylation Protein Kinases - metabolism Proteins - metabolism Troponin - metabolism Troponin I |
| title | Protein phosphorylation and compartments of cyclic AMP in the control of cardiac contraction |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T16%3A53%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protein%20phosphorylation%20and%20compartments%20of%20cyclic%20AMP%20in%20the%20control%20of%20cardiac%20contraction&rft.jtitle=Molecular%20and%20cellular%20biochemistry&rft.au=Murray,%20K%20J&rft.date=1989-09-07&rft.volume=89&rft.issue=2&rft.spage=175&rft.epage=179&rft.pages=175-179&rft.issn=0300-8177&rft.eissn=1573-4919&rft_id=info:doi/10.1007/bf00220772&rft_dat=%3Cproquest_cross%3E79302020%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15394357&rft_id=info:pmid/2554123&rfr_iscdi=true |