Modulation of nitric oxide production in RAW 264.7 cells by transforming growth factor-beta and interleukin-10: differential effects on free and encapsulated immunomodulator

The mouse macrophage cell line RAW 264.7 can be stimulated to produce nitric oxide (NO) by muramyltripeptide cholesterol included within biodegradable poly(D,L‐lactide) nanocapsules (NC MTP‐Chol). The aim of this work was to determine whether one or both of the cytokines transforming growth factor‐b...

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Veröffentlicht in:	Journal of leukocyte biology 1997-09, Vol.62 (3), p.374-380
Hauptverfasser:	Seyler, Isabelle, Appel, Martine, Devissaguet, Jean‐Philippe, Legrand, Philippe, Barratt, Gillian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylmuramyl-Alanyl-Isoglutamine - analogs & derivatives Acetylmuramyl-Alanyl-Isoglutamine - chemistry Acetylmuramyl-Alanyl-Isoglutamine - pharmacology Adjuvants, Immunologic - pharmacology Animals Cell Line Cholesterol Esters - pharmacology Enzyme Induction - drug effects Interleukin-10 - pharmacology macrophage activation Macrophage Activation - drug effects Macrophages - drug effects Macrophages - metabolism Mice muramyl‐dipeptide nanocapsules Nitric Oxide - biosynthesis Nitric Oxide Synthase - metabolism NO synthase Phagocytosis - drug effects Transforming Growth Factor beta - pharmacology tumor necrosis factor
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