The interplay between binding energy and catalysis in the evolution of a catalytic antibody

Antibody catalysis 1 provides an opportunity to examine the evolution of binding energy and its relation to catalytic function in a system that has many parallels with natural enzymes. Here we report such a study involving an antibody AZ-28 that catalyses an oxy-Cope rearrangement, a pericyclic reac...

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Veröffentlicht in:	Nature (London) 1997-09, Vol.389 (6648), p.271-275
Hauptverfasser:	Ulrich, Helle D., Mundorff, Emily, Santarsiero, Bernard D., Driggers, Edward M., Stevens, Raymond C., Schultz, Peter G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - metabolism Alkadienes - metabolism Amino Acid Sequence Amino acids Animals Antibodies, Catalytic - chemistry Antibodies, Catalytic - genetics Antibodies, Catalytic - metabolism Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - genetics Antibodies, Monoclonal - metabolism Biochemistry Catalysis Cloning, Molecular Crystallography, X-Ray Electrochemistry Evolution Evolution, Molecular Germ-Line Mutation Humanities and Social Sciences Immune system Immunity (Disease) Immunization Immunoglobulin Variable Region - genetics letter Medical research Mice Molecular Sequence Data multidisciplinary Mutation Protein Conformation Science Science (multidisciplinary)
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