Activated protein C resistance in normal pregnancy
This prospective cross‐sectional (10 women on each occasion) and longitudinal (20 women) study investigated activated protein C (APC) ratio in normal pregnancy. The APC ratio was measured at booking, 20, 30 and 36 weeks of gestation, and compared with a sample of normal nonpregnant women. No signifi...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 1997-09, Vol.104 (9), p.1084-1086 |
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| container_issue | 9 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
| container_volume | 104 |
| creator | Peek, Michael J. Nelson‐Piercy, Catherine Manning, Richard A. Swiet, Michael Letsky, Elizabeth A. |
| description | This prospective cross‐sectional (10 women on each occasion) and longitudinal (20 women) study investigated activated protein C (APC) ratio in normal pregnancy. The APC ratio was measured at booking, 20, 30 and 36 weeks of gestation, and compared with a sample of normal nonpregnant women. No significant difference was found between APC ratios for pregnant women at any gestation and those of the nonpregnant population in either the longitudinal or cross‐sectional studies. There was a significant decrease in APC ratios throughout pregnancy, but in all but one case values remained within the normal nonpregnant range. The APC ratio can therefore be used as a screening test for the factor V Leiden mutation during pregnancy. |
| doi_str_mv | 10.1111/j.1471-0528.1997.tb12072.x |
| format | Article |
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The APC ratio was measured at booking, 20, 30 and 36 weeks of gestation, and compared with a sample of normal nonpregnant women. No significant difference was found between APC ratios for pregnant women at any gestation and those of the nonpregnant population in either the longitudinal or cross‐sectional studies. There was a significant decrease in APC ratios throughout pregnancy, but in all but one case values remained within the normal nonpregnant range. The APC ratio can therefore be used as a screening test for the factor V Leiden mutation during pregnancy.</description><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Pilot Projects</subject><subject>Pregnancy - blood</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Protein C - metabolism</subject><subject>Sensitivity and Specificity</subject><issn>1470-0328</issn><issn>0306-5456</issn><issn>1471-0528</issn><issn>1365-215X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtOwzAQRS0EKqXwCUgRQuwS_Ehimw0qFU9V6qZ7y3HGKFWSFjuF9u9xaNQ93tjje2fm6iB0Q3BCwrlfJSTlJMYZFQmRkiddQSjmNNmdoPFROv174xgzKs7RhfcrjElOMRuhkWSYZykeIzo1XfWtOyijjVt3ULXRLHLgK9_p1kAU6nbtGl0HGT7b8Le_RGdW1x6uhnuCli_Py9lbPF-8vs-m89gwKdPYZEZoiQ2zghEQ1hLLOQ9xWWEzpvMMWymYZprYlBZADSsFcG4MLw2nhE3Q3WFsyPW1Bd-ppvIG6lq3sN56xSWVnNAsGB8ORuPW3juwauOqRru9Ilj1vNRK9VBUD0X1vNTAS-1C8_WwZVs0UB5bB0BBvx107Y2urQsEKn-0US55nvdhHw-2n6qG_T8CqKePBcEiZb8FUYbX</recordid><startdate>199709</startdate><enddate>199709</enddate><creator>Peek, Michael J.</creator><creator>Nelson‐Piercy, Catherine</creator><creator>Manning, Richard A.</creator><creator>Swiet, Michael</creator><creator>Letsky, Elizabeth A.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199709</creationdate><title>Activated protein C resistance in normal pregnancy</title><author>Peek, Michael J. ; Nelson‐Piercy, Catherine ; Manning, Richard A. ; Swiet, Michael ; Letsky, Elizabeth A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3994-c5c8a90c3f831e8ff1f7771993bf53a650f983a3a1f42be2c3d8e77cc7dc7213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Pilot Projects</topic><topic>Pregnancy - blood</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Protein C - metabolism</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peek, Michael J.</creatorcontrib><creatorcontrib>Nelson‐Piercy, Catherine</creatorcontrib><creatorcontrib>Manning, Richard A.</creatorcontrib><creatorcontrib>Swiet, Michael</creatorcontrib><creatorcontrib>Letsky, Elizabeth A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peek, Michael J.</au><au>Nelson‐Piercy, Catherine</au><au>Manning, Richard A.</au><au>Swiet, Michael</au><au>Letsky, Elizabeth A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activated protein C resistance in normal pregnancy</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>Br J Obstet Gynaecol</addtitle><date>1997-09</date><risdate>1997</risdate><volume>104</volume><issue>9</issue><spage>1084</spage><epage>1086</epage><pages>1084-1086</pages><issn>1470-0328</issn><issn>0306-5456</issn><eissn>1471-0528</eissn><eissn>1365-215X</eissn><coden>BJOGAS</coden><abstract>This prospective cross‐sectional (10 women on each occasion) and longitudinal (20 women) study investigated activated protein C (APC) ratio in normal pregnancy. 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| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 1997-09, Vol.104 (9), p.1084-1086 |
| issn | 1470-0328 0306-5456 1471-0528 1365-215X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79297125 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Biomarkers - blood Cross-Sectional Studies Female Gynecology. Andrology. Obstetrics Humans Longitudinal Studies Management. Prenatal diagnosis Medical sciences Pilot Projects Pregnancy - blood Pregnancy. Fetus. Placenta Protein C - metabolism Sensitivity and Specificity |
| title | Activated protein C resistance in normal pregnancy |
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