The slope parameter of concentration-response curves used as a touchstone for the existence of spare receptors

The present work was stimulated by findings of a large reserve of presynaptic alpha2-autoreceptors in rat neocortex by different investigators and our own group, using classical models of receptor agonism. The mathematical background of these classical models seems erroneous since the asymmetry that...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 1997-09, Vol.356 (3), p.283-292
Hauptverfasser:	Agneter, E, Singer, E A, Sauermann, W, Feuerstein, T J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Antagonists - pharmacology Animals Autoreceptors - agonists Brimonidine Tartrate Cerebral Cortex - metabolism Clonidine - pharmacology Dose-Response Relationship, Drug Electric Stimulation Models, Theoretical Norepinephrine - metabolism Norepinephrine - pharmacology Quinolines - pharmacology Quinoxalines - pharmacology Rats
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