Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long-term iodine prophylaxis and abundant iodine intake
OBJECTIVE To investigate the effect of varying amounts of iodine intake on the prevalence of thyroid dysfunction, autoimmunity and goitre in old age. DESIGN The first screening study where elderly subjects with varying amounts of iodine supply but from the same geographical and ethnographical region...
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| Veröffentlicht in: | Clinical endocrinology (Oxford) 1997-07, Vol.47 (1), p.87-92 |
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| creator | Szabolcs, István Podoba, Jan Feldkamp, Joachim Dohán, Orsolya Farkas, Ildikó Sajgó, Mihályné Takáts, Krisztina I. Góth, Miklós Kovács, László Kressinszky, Katalin Hnilica, Peter Szilágyi, Géza |
| description | OBJECTIVE
To investigate the effect of varying amounts of iodine intake on the prevalence of thyroid dysfunction, autoimmunity and goitre in old age.
DESIGN
The first screening study where elderly subjects with varying amounts of iodine supply but from the same geographical and ethnographical region (Carpathian basin) were compared, and all hormone measurements and ultrasonography were performed by the same laboratory or person.
PATIENTS
Nursing home residents were screened for thyroid disorders from: (A) an iodine‐deficient area, Northern Hungary (n = 119; median age 81 years; median iodine excretion (MIE) 0.065 μmol/mmol creatinine (equivalent to 72 μg/g creatinine); (B) an area of obligatory iodinated salt prophylaxis since the 1950s, Slovakia (n = 135; median age 81 years, MIE 0.090 μmol/mmol creatinine (equivalent to 100 μg/g creatinine)) and (C) an abundant iodine intake area, Eastern Hungary (n = 92; median age 78 years; MIE 0.462 μmol/mmol creatinine (equivalent to 513 μg/g creatinine)).
MEASUREMENTS
TSH, T4, free T4, T3, thyroglobulin (Tg), antibodies to Tg (AbTg) and to thyroid peroxidase (AbTPO), iodine excretion, ultrasonography of the thyroid gland.
RESULTS
In regions A, B and C, the prevalence of unsuspected clinical hypothyroidism was 0.8%, 1.5% and 7.6% (P = 0.006), with all cases except one being antibody positive (Ab+). The occurrence of subclinical hypothyroidism was 4.2% in region A, 10.4% in region B and 23.9% in region C (P |
| doi_str_mv | 10.1046/j.1365-2265.1997.2271040.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79295100</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79295100</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5027-286f63797ac80e88118fc78a1d29063020c134c40ac939bc78528d827401e8333</originalsourceid><addsrcrecordid>eNqVkcFu1DAQhiMEKkvhEZAshDiRMLaTOOGAhFalIFVFiEKPlteebL3N2oudhc1D8M442nTvnGzr--ef8T9Z9opCQaGs320KyusqZ6yuCtq2omBMJADF4VG2OKHH2QI4QA51XT7NnsW4AYCqAXGWnbUcGBdikf1d-u1OBTXY30iiDojOujXpfCDD3Ri8NcTY6IPBEIl1xPeGqDVOVxVQReI7Yr2xDonBzmqLTo9vSe_dOh8wbB_gLvjd3dirg41EueSx2juj3PDArRvUPT7PnnSqj_hiPs-zH58ubpaf86uvl1-WH69yXQETOWvqruaiFUo3gE1DadNp0ShqWAt1-hpoyktdgtItb1cJVawxDRMlUGw45-fZm6NvGuvXHuMgtzZq7Hvl0O-jFC1rKwqQhO-PQh18jAE7uQt2q8IoKchpF3Ijp8DlFLicdiHnXchDKn45d9mvtmhOpXP4ib-euYpa9V1QTtt4kjFRpenbJPtwlP2xPY7_MYBcXlynRzLIjwY2Dng4GahwL2vBRSVvry-l-AZAf95-lzf8H6O_tP8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79295100</pqid></control><display><type>article</type><title>Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long-term iodine prophylaxis and abundant iodine intake</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Szabolcs, István ; Podoba, Jan ; Feldkamp, Joachim ; Dohán, Orsolya ; Farkas, Ildikó ; Sajgó, Mihályné ; Takáts, Krisztina I. ; Góth, Miklós ; Kovács, László ; Kressinszky, Katalin ; Hnilica, Peter ; Szilágyi, Géza</creator><creatorcontrib>Szabolcs, István ; Podoba, Jan ; Feldkamp, Joachim ; Dohán, Orsolya ; Farkas, Ildikó ; Sajgó, Mihályné ; Takáts, Krisztina I. ; Góth, Miklós ; Kovács, László ; Kressinszky, Katalin ; Hnilica, Peter ; Szilágyi, Géza</creatorcontrib><description>OBJECTIVE
To investigate the effect of varying amounts of iodine intake on the prevalence of thyroid dysfunction, autoimmunity and goitre in old age.
DESIGN
The first screening study where elderly subjects with varying amounts of iodine supply but from the same geographical and ethnographical region (Carpathian basin) were compared, and all hormone measurements and ultrasonography were performed by the same laboratory or person.
PATIENTS
Nursing home residents were screened for thyroid disorders from: (A) an iodine‐deficient area, Northern Hungary (n = 119; median age 81 years; median iodine excretion (MIE) 0.065 μmol/mmol creatinine (equivalent to 72 μg/g creatinine); (B) an area of obligatory iodinated salt prophylaxis since the 1950s, Slovakia (n = 135; median age 81 years, MIE 0.090 μmol/mmol creatinine (equivalent to 100 μg/g creatinine)) and (C) an abundant iodine intake area, Eastern Hungary (n = 92; median age 78 years; MIE 0.462 μmol/mmol creatinine (equivalent to 513 μg/g creatinine)).
MEASUREMENTS
TSH, T4, free T4, T3, thyroglobulin (Tg), antibodies to Tg (AbTg) and to thyroid peroxidase (AbTPO), iodine excretion, ultrasonography of the thyroid gland.
RESULTS
In regions A, B and C, the prevalence of unsuspected clinical hypothyroidism was 0.8%, 1.5% and 7.6% (P = 0.006), with all cases except one being antibody positive (Ab+). The occurrence of subclinical hypothyroidism was 4.2% in region A, 10.4% in region B and 23.9% in region C (P < 0.001), but only 3 of 22 cases with subclinical hypothyroidism from region C were Ab+. The overall prevalence of Ab positivity (either antiTg+ or antiTPO+) was similar in the three regions (A, 19.3%; B, 24.4%; C, 22.8%). The occurrence of hyperthyroidism (clinical plus subclinical) was 3.4% in region A, 3.0% in region B and 0% in region C (not significant). The rate of elevated Tg levels was similar in the three regions. The prevalence of goitre was 39.4%, 16.4% and 12.2% (P < 0.001), respectively in regions A, B and C. In euthyroid subjects the mean ultrasonographically determined thyroid volume was 21.9 ml in region A, 13.6 ml in region B and 15.1 ml in region C (ANOVA F = 5.76; P = 0.0038). There was no significant difference in the occurrence of cases with hypoechogenic echotexture of the thyroid gland.
CONCLUSIONS
The screening for hypothyroidism in nursing home residents living in iodine‐rich regions is justified by the high prevalence of unsuspected clinical hypothyroidism. The high prevalence of antibody positivity in old age is independent of the iodine supply, but iodine supply has a determining role in the development of autoimmune hypothyroidism in the aged. Most cases of subclinical hypothyroidism in iodine‐rich regions are not of autoimmune origin. In old age, hypoechogenic texture of the thyroid gland is not predictive of thyroid dysfunction.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1046/j.1365-2265.1997.2271040.x</identifier><identifier>PMID: 9302377</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Aged ; Aged, 80 and over ; Autoimmune Diseases - diagnostic imaging ; Autoimmune Diseases - epidemiology ; Autoimmune Diseases - metabolism ; Biological and medical sciences ; Cross-Sectional Studies ; Endocrinopathies ; Female ; Goiter - epidemiology ; Goiter - metabolism ; Humans ; Hungary - epidemiology ; Hypothyroidism - diagnostic imaging ; Hypothyroidism - etiology ; Hypothyroidism - metabolism ; Iodine - administration & dosage ; Iodine - deficiency ; Male ; Medical sciences ; Middle Aged ; Non tumoral diseases. Target tissue resistance. Benign neoplasms ; Prevalence ; Slovakia - epidemiology ; Thyroid Diseases - diagnostic imaging ; Thyroid Diseases - epidemiology ; Thyroid Diseases - metabolism ; Thyroid Gland - diagnostic imaging ; Thyroid. Thyroid axis (diseases) ; Ultrasonography</subject><ispartof>Clinical endocrinology (Oxford), 1997-07, Vol.47 (1), p.87-92</ispartof><rights>Blackwell Science Ltd, Oxford</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5027-286f63797ac80e88118fc78a1d29063020c134c40ac939bc78528d827401e8333</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2265.1997.2271040.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2265.1997.2271040.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2759399$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9302377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szabolcs, István</creatorcontrib><creatorcontrib>Podoba, Jan</creatorcontrib><creatorcontrib>Feldkamp, Joachim</creatorcontrib><creatorcontrib>Dohán, Orsolya</creatorcontrib><creatorcontrib>Farkas, Ildikó</creatorcontrib><creatorcontrib>Sajgó, Mihályné</creatorcontrib><creatorcontrib>Takáts, Krisztina I.</creatorcontrib><creatorcontrib>Góth, Miklós</creatorcontrib><creatorcontrib>Kovács, László</creatorcontrib><creatorcontrib>Kressinszky, Katalin</creatorcontrib><creatorcontrib>Hnilica, Peter</creatorcontrib><creatorcontrib>Szilágyi, Géza</creatorcontrib><title>Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long-term iodine prophylaxis and abundant iodine intake</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clinical Endocrinology</addtitle><description>OBJECTIVE
To investigate the effect of varying amounts of iodine intake on the prevalence of thyroid dysfunction, autoimmunity and goitre in old age.
DESIGN
The first screening study where elderly subjects with varying amounts of iodine supply but from the same geographical and ethnographical region (Carpathian basin) were compared, and all hormone measurements and ultrasonography were performed by the same laboratory or person.
PATIENTS
Nursing home residents were screened for thyroid disorders from: (A) an iodine‐deficient area, Northern Hungary (n = 119; median age 81 years; median iodine excretion (MIE) 0.065 μmol/mmol creatinine (equivalent to 72 μg/g creatinine); (B) an area of obligatory iodinated salt prophylaxis since the 1950s, Slovakia (n = 135; median age 81 years, MIE 0.090 μmol/mmol creatinine (equivalent to 100 μg/g creatinine)) and (C) an abundant iodine intake area, Eastern Hungary (n = 92; median age 78 years; MIE 0.462 μmol/mmol creatinine (equivalent to 513 μg/g creatinine)).
MEASUREMENTS
TSH, T4, free T4, T3, thyroglobulin (Tg), antibodies to Tg (AbTg) and to thyroid peroxidase (AbTPO), iodine excretion, ultrasonography of the thyroid gland.
RESULTS
In regions A, B and C, the prevalence of unsuspected clinical hypothyroidism was 0.8%, 1.5% and 7.6% (P = 0.006), with all cases except one being antibody positive (Ab+). The occurrence of subclinical hypothyroidism was 4.2% in region A, 10.4% in region B and 23.9% in region C (P < 0.001), but only 3 of 22 cases with subclinical hypothyroidism from region C were Ab+. The overall prevalence of Ab positivity (either antiTg+ or antiTPO+) was similar in the three regions (A, 19.3%; B, 24.4%; C, 22.8%). The occurrence of hyperthyroidism (clinical plus subclinical) was 3.4% in region A, 3.0% in region B and 0% in region C (not significant). The rate of elevated Tg levels was similar in the three regions. The prevalence of goitre was 39.4%, 16.4% and 12.2% (P < 0.001), respectively in regions A, B and C. In euthyroid subjects the mean ultrasonographically determined thyroid volume was 21.9 ml in region A, 13.6 ml in region B and 15.1 ml in region C (ANOVA F = 5.76; P = 0.0038). There was no significant difference in the occurrence of cases with hypoechogenic echotexture of the thyroid gland.
CONCLUSIONS
The screening for hypothyroidism in nursing home residents living in iodine‐rich regions is justified by the high prevalence of unsuspected clinical hypothyroidism. The high prevalence of antibody positivity in old age is independent of the iodine supply, but iodine supply has a determining role in the development of autoimmune hypothyroidism in the aged. Most cases of subclinical hypothyroidism in iodine‐rich regions are not of autoimmune origin. In old age, hypoechogenic texture of the thyroid gland is not predictive of thyroid dysfunction.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autoimmune Diseases - diagnostic imaging</subject><subject>Autoimmune Diseases - epidemiology</subject><subject>Autoimmune Diseases - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cross-Sectional Studies</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Goiter - epidemiology</subject><subject>Goiter - metabolism</subject><subject>Humans</subject><subject>Hungary - epidemiology</subject><subject>Hypothyroidism - diagnostic imaging</subject><subject>Hypothyroidism - etiology</subject><subject>Hypothyroidism - metabolism</subject><subject>Iodine - administration & dosage</subject><subject>Iodine - deficiency</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Non tumoral diseases. Target tissue resistance. Benign neoplasms</subject><subject>Prevalence</subject><subject>Slovakia - epidemiology</subject><subject>Thyroid Diseases - diagnostic imaging</subject><subject>Thyroid Diseases - epidemiology</subject><subject>Thyroid Diseases - metabolism</subject><subject>Thyroid Gland - diagnostic imaging</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Ultrasonography</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcFu1DAQhiMEKkvhEZAshDiRMLaTOOGAhFalIFVFiEKPlteebL3N2oudhc1D8M442nTvnGzr--ef8T9Z9opCQaGs320KyusqZ6yuCtq2omBMJADF4VG2OKHH2QI4QA51XT7NnsW4AYCqAXGWnbUcGBdikf1d-u1OBTXY30iiDojOujXpfCDD3Ri8NcTY6IPBEIl1xPeGqDVOVxVQReI7Yr2xDonBzmqLTo9vSe_dOh8wbB_gLvjd3dirg41EueSx2juj3PDArRvUPT7PnnSqj_hiPs-zH58ubpaf86uvl1-WH69yXQETOWvqruaiFUo3gE1DadNp0ShqWAt1-hpoyktdgtItb1cJVawxDRMlUGw45-fZm6NvGuvXHuMgtzZq7Hvl0O-jFC1rKwqQhO-PQh18jAE7uQt2q8IoKchpF3Ijp8DlFLicdiHnXchDKn45d9mvtmhOpXP4ib-euYpa9V1QTtt4kjFRpenbJPtwlP2xPY7_MYBcXlynRzLIjwY2Dng4GahwL2vBRSVvry-l-AZAf95-lzf8H6O_tP8</recordid><startdate>199707</startdate><enddate>199707</enddate><creator>Szabolcs, István</creator><creator>Podoba, Jan</creator><creator>Feldkamp, Joachim</creator><creator>Dohán, Orsolya</creator><creator>Farkas, Ildikó</creator><creator>Sajgó, Mihályné</creator><creator>Takáts, Krisztina I.</creator><creator>Góth, Miklós</creator><creator>Kovács, László</creator><creator>Kressinszky, Katalin</creator><creator>Hnilica, Peter</creator><creator>Szilágyi, Géza</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199707</creationdate><title>Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long-term iodine prophylaxis and abundant iodine intake</title><author>Szabolcs, István ; Podoba, Jan ; Feldkamp, Joachim ; Dohán, Orsolya ; Farkas, Ildikó ; Sajgó, Mihályné ; Takáts, Krisztina I. ; Góth, Miklós ; Kovács, László ; Kressinszky, Katalin ; Hnilica, Peter ; Szilágyi, Géza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5027-286f63797ac80e88118fc78a1d29063020c134c40ac939bc78528d827401e8333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autoimmune Diseases - diagnostic imaging</topic><topic>Autoimmune Diseases - epidemiology</topic><topic>Autoimmune Diseases - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cross-Sectional Studies</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Goiter - epidemiology</topic><topic>Goiter - metabolism</topic><topic>Humans</topic><topic>Hungary - epidemiology</topic><topic>Hypothyroidism - diagnostic imaging</topic><topic>Hypothyroidism - etiology</topic><topic>Hypothyroidism - metabolism</topic><topic>Iodine - administration & dosage</topic><topic>Iodine - deficiency</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Non tumoral diseases. Target tissue resistance. Benign neoplasms</topic><topic>Prevalence</topic><topic>Slovakia - epidemiology</topic><topic>Thyroid Diseases - diagnostic imaging</topic><topic>Thyroid Diseases - epidemiology</topic><topic>Thyroid Diseases - metabolism</topic><topic>Thyroid Gland - diagnostic imaging</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szabolcs, István</creatorcontrib><creatorcontrib>Podoba, Jan</creatorcontrib><creatorcontrib>Feldkamp, Joachim</creatorcontrib><creatorcontrib>Dohán, Orsolya</creatorcontrib><creatorcontrib>Farkas, Ildikó</creatorcontrib><creatorcontrib>Sajgó, Mihályné</creatorcontrib><creatorcontrib>Takáts, Krisztina I.</creatorcontrib><creatorcontrib>Góth, Miklós</creatorcontrib><creatorcontrib>Kovács, László</creatorcontrib><creatorcontrib>Kressinszky, Katalin</creatorcontrib><creatorcontrib>Hnilica, Peter</creatorcontrib><creatorcontrib>Szilágyi, Géza</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szabolcs, István</au><au>Podoba, Jan</au><au>Feldkamp, Joachim</au><au>Dohán, Orsolya</au><au>Farkas, Ildikó</au><au>Sajgó, Mihályné</au><au>Takáts, Krisztina I.</au><au>Góth, Miklós</au><au>Kovács, László</au><au>Kressinszky, Katalin</au><au>Hnilica, Peter</au><au>Szilágyi, Géza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long-term iodine prophylaxis and abundant iodine intake</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clinical Endocrinology</addtitle><date>1997-07</date><risdate>1997</risdate><volume>47</volume><issue>1</issue><spage>87</spage><epage>92</epage><pages>87-92</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>OBJECTIVE
To investigate the effect of varying amounts of iodine intake on the prevalence of thyroid dysfunction, autoimmunity and goitre in old age.
DESIGN
The first screening study where elderly subjects with varying amounts of iodine supply but from the same geographical and ethnographical region (Carpathian basin) were compared, and all hormone measurements and ultrasonography were performed by the same laboratory or person.
PATIENTS
Nursing home residents were screened for thyroid disorders from: (A) an iodine‐deficient area, Northern Hungary (n = 119; median age 81 years; median iodine excretion (MIE) 0.065 μmol/mmol creatinine (equivalent to 72 μg/g creatinine); (B) an area of obligatory iodinated salt prophylaxis since the 1950s, Slovakia (n = 135; median age 81 years, MIE 0.090 μmol/mmol creatinine (equivalent to 100 μg/g creatinine)) and (C) an abundant iodine intake area, Eastern Hungary (n = 92; median age 78 years; MIE 0.462 μmol/mmol creatinine (equivalent to 513 μg/g creatinine)).
MEASUREMENTS
TSH, T4, free T4, T3, thyroglobulin (Tg), antibodies to Tg (AbTg) and to thyroid peroxidase (AbTPO), iodine excretion, ultrasonography of the thyroid gland.
RESULTS
In regions A, B and C, the prevalence of unsuspected clinical hypothyroidism was 0.8%, 1.5% and 7.6% (P = 0.006), with all cases except one being antibody positive (Ab+). The occurrence of subclinical hypothyroidism was 4.2% in region A, 10.4% in region B and 23.9% in region C (P < 0.001), but only 3 of 22 cases with subclinical hypothyroidism from region C were Ab+. The overall prevalence of Ab positivity (either antiTg+ or antiTPO+) was similar in the three regions (A, 19.3%; B, 24.4%; C, 22.8%). The occurrence of hyperthyroidism (clinical plus subclinical) was 3.4% in region A, 3.0% in region B and 0% in region C (not significant). The rate of elevated Tg levels was similar in the three regions. The prevalence of goitre was 39.4%, 16.4% and 12.2% (P < 0.001), respectively in regions A, B and C. In euthyroid subjects the mean ultrasonographically determined thyroid volume was 21.9 ml in region A, 13.6 ml in region B and 15.1 ml in region C (ANOVA F = 5.76; P = 0.0038). There was no significant difference in the occurrence of cases with hypoechogenic echotexture of the thyroid gland.
CONCLUSIONS
The screening for hypothyroidism in nursing home residents living in iodine‐rich regions is justified by the high prevalence of unsuspected clinical hypothyroidism. The high prevalence of antibody positivity in old age is independent of the iodine supply, but iodine supply has a determining role in the development of autoimmune hypothyroidism in the aged. Most cases of subclinical hypothyroidism in iodine‐rich regions are not of autoimmune origin. In old age, hypoechogenic texture of the thyroid gland is not predictive of thyroid dysfunction.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>9302377</pmid><doi>10.1046/j.1365-2265.1997.2271040.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-0664 |
| ispartof | Clinical endocrinology (Oxford), 1997-07, Vol.47 (1), p.87-92 |
| issn | 0300-0664 1365-2265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79295100 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Aged, 80 and over Autoimmune Diseases - diagnostic imaging Autoimmune Diseases - epidemiology Autoimmune Diseases - metabolism Biological and medical sciences Cross-Sectional Studies Endocrinopathies Female Goiter - epidemiology Goiter - metabolism Humans Hungary - epidemiology Hypothyroidism - diagnostic imaging Hypothyroidism - etiology Hypothyroidism - metabolism Iodine - administration & dosage Iodine - deficiency Male Medical sciences Middle Aged Non tumoral diseases. Target tissue resistance. Benign neoplasms Prevalence Slovakia - epidemiology Thyroid Diseases - diagnostic imaging Thyroid Diseases - epidemiology Thyroid Diseases - metabolism Thyroid Gland - diagnostic imaging Thyroid. Thyroid axis (diseases) Ultrasonography |
| title | Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long-term iodine prophylaxis and abundant iodine intake |
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