Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology
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| Veröffentlicht in: | Antimicrobial Agents and Chemotherapy 1997-09, Vol.41 (9), p.1859-1866 |
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| container_title | Antimicrobial Agents and Chemotherapy |
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| creator | SILVERMAN, J. A HAYES, M. L LUFT, B. J JOINER, K. A |
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| doi_str_mv | 10.1128/aac.41.9.1859 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/aac.41.9.1859</identifier><identifier>PMID: 9303374</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ; ATP-Binding Cassette, Sub-Family B, Member 1 - physiology ; Biological and medical sciences ; Calcium Channel Blockers - pharmacology ; Cercopithecus aethiops ; Coccidiostats ; Coccidiostats - pharmacokinetics ; Coccidiostats - pharmacology ; Cyclosporine - pharmacology ; Cyclosporins ; Cyclosporins - pharmacology ; Enzyme Inhibitors ; Enzyme Inhibitors - pharmacology ; Female ; Immunosuppressive Agents - pharmacology ; Medical sciences ; Mice ; Peptidylprolyl Isomerase - antagonists & inhibitors ; Pharmacology. Drug treatments ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S ; Rhodamine 123 ; Rhodamines - pharmacology ; Sensitivity and Specificity ; Toxoplasma ; Toxoplasma - drug effects ; Toxoplasma - growth & development ; Toxoplasma - metabolism ; Toxoplasma gondii ; Verapamil - pharmacology ; Vero Cells</subject><ispartof>Antimicrobial Agents and Chemotherapy, 1997-09, Vol.41 (9), p.1859-1866</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a568t-908b43fdf05a72134d49d741f10491a025a3d0813181f931d9390f6ebdaf55753</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC164025/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC164025/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2841596$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9303374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SILVERMAN, J. A</creatorcontrib><creatorcontrib>HAYES, M. L</creatorcontrib><creatorcontrib>LUFT, B. J</creatorcontrib><creatorcontrib>JOINER, K. A</creatorcontrib><title>Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Services
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</description><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>ATP Binding Cassette Transporter, Subfamily B, Member 1</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - physiology</subject><subject>Biological and medical sciences</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>Cercopithecus aethiops</subject><subject>Coccidiostats</subject><subject>Coccidiostats - pharmacokinetics</subject><subject>Coccidiostats - pharmacology</subject><subject>Cyclosporine - pharmacology</subject><subject>Cyclosporins</subject><subject>Cyclosporins - pharmacology</subject><subject>Enzyme Inhibitors</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Female</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Peptidylprolyl Isomerase - antagonists & inhibitors</subject><subject>Pharmacology. 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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>9303374</pmid><doi>10.1128/aac.41.9.1859</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 1997-09, Vol.41 (9), p.1859-1866 |
| issn | 0066-4804 1098-6596 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents ATP Binding Cassette Transporter, Subfamily B, Member 1 ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - physiology Biological and medical sciences Calcium Channel Blockers - pharmacology Cercopithecus aethiops Coccidiostats Coccidiostats - pharmacokinetics Coccidiostats - pharmacology Cyclosporine - pharmacology Cyclosporins Cyclosporins - pharmacology Enzyme Inhibitors Enzyme Inhibitors - pharmacology Female Immunosuppressive Agents - pharmacology Medical sciences Mice Peptidylprolyl Isomerase - antagonists & inhibitors Pharmacology. Drug treatments Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S Rhodamine 123 Rhodamines - pharmacology Sensitivity and Specificity Toxoplasma Toxoplasma - drug effects Toxoplasma - growth & development Toxoplasma - metabolism Toxoplasma gondii Verapamil - pharmacology Vero Cells |
| title | Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology |
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