Chronic effect of fatty acids on insulin release is not through the alteration of glucose metabolism in a pancreatic beta-cell line (βHC9)

Hyperinsulinaemia in the fasting state and a blunted insulin secretory response to acute glucose stimulation are commonly observed in obesity associated non-insulin-dependent diabetes mellitus. Hyperlipidaemia is a hallmark of obesity and may play a role in the pathogenesis of this beta-cell dysfunc...

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Veröffentlicht in:	Diabetologia 1997-09, Vol.40 (9), p.1018-1027
Hauptverfasser:	LIANG, Y, BUETTGER, C, BERNER, D. K, MATSCHINSKY, F. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Dose-Response Relationship, Drug Endocrine pancreas Fatty Acids - administration & dosage Fatty Acids - pharmacology Fundamental and applied biological sciences. Psychology Glucose - metabolism Hormones. Régulation Insulin - metabolism Insulin Secretion Islets of Langerhans - cytology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Mice Oleic Acid - administration & dosage Oleic Acid - pharmacology Oxygen Consumption - drug effects Oxygen Consumption - physiology Vertebrates: endocrinology
Online-Zugang:	Volltext
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